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NEST SIGNED

Nanoengineering of radioactive seeds for cancer therapy and diagnosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 NEST project word cloud

Explore the words cloud of the NEST project. It provides you a very rough idea of what is the project "NEST" about.

profile    nanostructures    hermetically    crystals    pharmacokinetic    alien    encased    modern    governed    obtain    leakage    prevalence    efficient    eradicate    worldwide    personalised    patients    diagnosis    oncology    nanocarrier    limitations    interior    sensitive    fate    unprecedented    survival    routes    hot    nanoparticles    preventing    nanomedicine    understand    treatments    nanotechnology    humans    employed    milieu    sealed    form    medicine    considerable    shape    tune    disease    small    origin    reduce    cancer    nanocarriers    physicochemical    overcome    ultra    rate    vivo    innovative    therapeutic    treatment    diseases    detection    seeds    area    approved    size    engineer    interaction    society    polymers    nanomaterials    efforts    tumour    agents    clinical    nest    biodistribution    encaged    merely    one    devoted    decades    impart    biological    rational    imaging    materials    surface    amount    engineering    nanoseeds    mortality    liposomes    radionuclides    hollow    incidence    reactivity    therapeutics   

Project "NEST" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙999˙965 €
 EC max contribution 1˙999˙965 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2022-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 1˙999˙965.00

Map

 Project objective

One of the major challenges in modern society is the early diagnosis and treatment of diseases. Cancer is one of the most relevant diseases worldwide because of its incidence, prevalence and mortality. During the past decades, considerable efforts have been devoted to understand the origin of the disease, find early detection methods that could improve the survival rate of cancer patients or develop treatments and devices that could reduce or eradicate cancer. The application of nanotechnology to medicine (nanomedicine) has become one of the most promising routes for the diagnosis and treatment of diseases. The small size of nanomaterials, large surface area and high reactivity impart unique physicochemical properties to these materials, in such a way that several therapeutics based on nanomaterials (liposomes, nanoparticles, polymers) have already been approved for clinical use in humans. However, there are still limitations that need to be overcome to obtain novel and efficient nanocarriers for oncology applications.

NEST presents an innovative approach that aims to engineer ultra-sensitive imaging and therapeutic agents. An unprecedented amount of ‘hot’ radionuclides, in the form of crystals, will be hermetically sealed in the interior of hollow nanostructures (seeds), thus preventing leakage and interaction of the radionuclides with the biological milieu. The in vivo fate will thus be merely governed by the nanocarrier and will be alien to the encaged radionuclides. Rational engineering of the nanoseeds in terms of size, shape and surface properties will be employed to tune their pharmacokinetic profile and biodistribution, including tumour targeting. The large amount of radionuclides encased in each of the seeds is expected to allow a more personalised treatment of cancer and ultra-sensitive imaging, for an early diagnosis.

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The information about "NEST" are provided by the European Opendata Portal: CORDIS opendata.

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