Opendata, web and dolomites

INTUMORX

Elucidation of intratumoral heterogeneity in Kras-driven cancers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 INTUMORX project word cloud

Explore the words cloud of the INTUMORX project. It provides you a very rough idea of what is the project "INTUMORX" about.

multiclonality    leads    resistant    reporter    human    survival    delta    lentiviral    reconstitution    modified    indicate    lineage    heterogeneity    components    prolonged    autochthonous    populations    stasis    provides    maintenance    cellular    tracing    advantageous    model    cellullar    therapy    resistance    regeneration    mechanisms    wnt    therapeutic    cell    small    tissue    krasg12d    signaling    epithelial    forming    combination    molecule    mice    cancers    cancer    signal    responder    hypothesized    signals    ed    variability    silencing    cells    vectors    engineered    tp53    tumors    had    experiments    selective    tissues    vivo    demonstrated    strikingly    elucidate    molecules    tumor    genetically    stem    molecular    luad    collectively    phenotypes    mouse    microenvironments    hierarchical    lung    propagation    adenocarcinomas    vitro    kp    inhibitors    probablility    considerable    niche    ablation    subpopulation    treatment    intratumoral    efforts    suppressed    normal    population    crispr    exhibited    context   

Project "INTUMORX" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙972˙905 €
 EC max contribution 1˙972˙905 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 1˙972˙905.00

Map

 Project objective

The considerable variability within tissue microenvironments as well as the multiclonality of cancers leads to intratumoral heterogeneity. This increases the probablility of cellular states that promote resistance to therapy and eventually lead to reconstitution of the tumor by treatment-resistant cancer cells, which in some cases have properties of normal tissue stem cells. Wnt signals are important in the maintenance of stem cells in various epithelial tissues, including in lung development and regeneration. We hypothesized that Wnt signals contribute to tumor heterogeneity in genetically engineered KrasG12D; Tp53Δ/Δ (”KP”) mouse lung adenocarcinomas (LUAD). We observed that a subpopulation of LUAD cells exhibited high Wnt reporter activity and had increased tumor forming ability, which could be suppressed by silencing of Wnt signaling pathway components or by small molecule Wnt inhibitors in vitro and in vivo. KP LUAD cells show hierarchical features with two distinct populations, one with increased Wnt reporter activity and another forming a niche that provides the Wnt signal. Lineage-tracing experiments in the autochthonous KP tumors demonstrated that Wnt responder cells have increased tumor propagation ability in vivo. Strikingly, selective ablation of the Wnt responder cells resulted in tumor stasis. CRISPR-based targeting or small molecules targeting Wnt signaling reduced tumor growth and prolonged survival in the autochthonous KP mouse lung cancer model. These results indicate that maintenance of heterogeneity within tumors may be advantageous for the tumor cell population collectively. We propose to elucidate the molecular and cellullar mechanisms that control stem-like and niche cell phenotypes using a combination of novel lentiviral vectors and genetically modified mice in the context of the KP LUAD model. These efforts may lead to novel therapeutic concepts in human lung cancer.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "INTUMORX" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "INTUMORX" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

evolSingleCellGRN (2019)

Constraint, Adaptation, and Heterogeneity: Genomic and single-cell approaches to understanding the evolution of developmental gene regulatory networks

Read More  

IMMUNOTHROMBOSIS (2019)

Cross-talk between platelets and immunity - implications for host homeostasis and defense

Read More  

RODRESET (2019)

Development of novel optogenetic approaches for improving vision in macular degeneration

Read More