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INTUMORX

Elucidation of intratumoral heterogeneity in Kras-driven cancers

Total Cost €

0

EC-Contrib. €

0

Partnership

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 INTUMORX project word cloud

Explore the words cloud of the INTUMORX project. It provides you a very rough idea of what is the project "INTUMORX" about.

components    vitro    experiments    cellullar    small    demonstrated    populations    combination    mechanisms    probablility    ed    had    cancer    survival    epithelial    wnt    niche    microenvironments    propagation    selective    vectors    intratumoral    autochthonous    signaling    therapy    collectively    genetically    silencing    heterogeneity    responder    signal    kp    signals    regeneration    reporter    stem    indicate    human    reconstitution    engineered    subpopulation    advantageous    variability    tumors    therapeutic    cancers    context    maintenance    tissue    strikingly    inhibitors    tumor    luad    delta    resistant    molecules    adenocarcinomas    molecular    treatment    modified    exhibited    cell    considerable    phenotypes    forming    hypothesized    resistance    multiclonality    tp53    krasg12d    leads    normal    cellular    mice    model    ablation    stasis    crispr    lung    cells    lentiviral    elucidate    provides    molecule    tracing    tissues    lineage    suppressed    prolonged    vivo    mouse    population    hierarchical    efforts   

Project "INTUMORX" data sheet

The following table provides information about the project.

Coordinator
HELSINGIN YLIOPISTO 

Organization address
address: YLIOPISTONKATU 3
city: HELSINGIN YLIOPISTO
postcode: 14
website: www.helsinki.fi

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Finland [FI]
 Total cost 1˙972˙905 €
 EC max contribution 1˙972˙905 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-07-01   to  2022-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    HELSINGIN YLIOPISTO FI (HELSINGIN YLIOPISTO) coordinator 1˙972˙905.00

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 Project objective

The considerable variability within tissue microenvironments as well as the multiclonality of cancers leads to intratumoral heterogeneity. This increases the probablility of cellular states that promote resistance to therapy and eventually lead to reconstitution of the tumor by treatment-resistant cancer cells, which in some cases have properties of normal tissue stem cells. Wnt signals are important in the maintenance of stem cells in various epithelial tissues, including in lung development and regeneration. We hypothesized that Wnt signals contribute to tumor heterogeneity in genetically engineered KrasG12D; Tp53Δ/Δ (”KP”) mouse lung adenocarcinomas (LUAD). We observed that a subpopulation of LUAD cells exhibited high Wnt reporter activity and had increased tumor forming ability, which could be suppressed by silencing of Wnt signaling pathway components or by small molecule Wnt inhibitors in vitro and in vivo. KP LUAD cells show hierarchical features with two distinct populations, one with increased Wnt reporter activity and another forming a niche that provides the Wnt signal. Lineage-tracing experiments in the autochthonous KP tumors demonstrated that Wnt responder cells have increased tumor propagation ability in vivo. Strikingly, selective ablation of the Wnt responder cells resulted in tumor stasis. CRISPR-based targeting or small molecules targeting Wnt signaling reduced tumor growth and prolonged survival in the autochthonous KP mouse lung cancer model. These results indicate that maintenance of heterogeneity within tumors may be advantageous for the tumor cell population collectively. We propose to elucidate the molecular and cellullar mechanisms that control stem-like and niche cell phenotypes using a combination of novel lentiviral vectors and genetically modified mice in the context of the KP LUAD model. These efforts may lead to novel therapeutic concepts in human lung cancer.

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The information about "INTUMORX" are provided by the European Opendata Portal: CORDIS opendata.

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