Opendata, web and dolomites

COSY-BIO SIGNED

Control Engineering of Biological Systems for Reliable Synthetic Biology Applications

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "COSY-BIO" data sheet

The following table provides information about the project.

Coordinator
FONDAZIONE TELETHON 

Organization address
address: VIA VARESE 16/B
city: ROMA
postcode: 185
website: www.telethon.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.cosy-bio.eu
 Total cost 2˙996˙856 €
 EC max contribution 2˙975˙345 € (99%)
 Programme 1. H2020-EU.1.2.1. (FET Open)
 Code Call H2020-FETOPEN-1-2016-2017
 Funding Scheme RIA
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2020-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FONDAZIONE TELETHON IT (ROMA) coordinator 555˙875.00
2    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) participant 568˙347.00
3    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) participant 400˙000.00
4    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) participant 398˙526.00
5    UNIVERSITY OF BRISTOL UK (BRISTOL) participant 298˙196.00
6    UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II IT (NAPOLI) participant 255˙500.00
7    INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE FR (LE CHESNAY CEDEX) participant 250˙000.00
8    UNIVERSITE DE PARIS FR (PARIS) participant 248˙900.00
9    UNIVERSITE PARIS DIDEROT - PARIS 7 FR (PARIS) participant 0.00

Map

 Project objective

Synthetic Biology aims at rational engineering of living organisms to improve human well-being and environmental sustainability, thus promising a paradigm shift in human technology. Its full potential has not been achieved yet because of the complexity of engineering biological systems where basic biological parts are intrinsically noisy and not modular. The overarching goal of COSY-BIO is to develop a theoretical framework and innovative technological tools to engineer reliable biological systems that are robust despite their individual components being not by translating principles of control engineering to molecular and cell biology. Automatic control is a well-established engineering discipline to build “controllers” to steer the dynamic behaviour of a physical system in a desired fashion. By building upon control engineering for physical systems and by exploiting the unique features of living organisms, this project will identify generally applicable approaches to design closed-loop feedback controllers for biological systems. To handle biological complexity, the project will explore three strategies of increasing difficulty “external” controllers, “embedded” controllers and “multi-cellular” controllers. External controllers will be implemented in a computer acting on cells using small molecules via microfluidics devices. Embedded controllers will be made from biological parts and integrated within individual cells to steer their behaviour. Multicellular controllers envisage two cell populations, one made up of cells with embedded controllers (controller cells) and the other will be the controlled population (target cells). In addition, a rapid prototyping platform will enable to speed up the design-build-test cycles by means of optimal experimental design, microfluidics and cell-free systems. Proof-of-principles demonstrations in bacteria and yeast with relevance to biotechnology will be tackled to prove the usefulness of this revolutionary technology.

 Deliverables

List of deliverables.
Detailed Dissemination and Exploitation plan Open Research Data Pilot 2020-02-19 08:19:36
Comparison of model identification strategies Documents, reports 2020-02-19 08:19:36
Constructing and testing of reporters of the cell cycle Demonstrators, pilots, prototypes 2020-02-19 08:19:36
Official Logo of COSY-BIO Other 2020-02-19 08:19:36
Data Management plan Open Research Data Pilot 2020-02-19 08:19:36
Website and intranet portal Other 2020-02-19 08:19:36

Take a look to the deliverables list in detail:  detailed list of COSY-BIO deliverables.

 Publications

year authors and title journal last update
List of publications.
2018 Gabriele Lillacci, Yaakov Benenson, Mustafa Khammash
Synthetic control systems for high performance gene expression in mammalian cells
published pages: 9855-9863, ISSN: 0305-1048, DOI: 10.1093/nar/gky795
Nucleic Acids Research 46/18 2020-02-19
2018 Lucia Bandiera, Zhaozheng Hou, Varun Kothamachu, Eva Balsa-Canto, Peter Swain, Filippo Menolascina
On-Line Optimal Input Design Increases the Efficiency and Accuracy of the Modelling of an Inducible Synthetic Promoter
published pages: 148, ISSN: 2227-9717, DOI: 10.3390/pr6090148
Processes 6/9 2020-02-19
2018 Nicolas Kylilis, Zoltan A. Tuza, Guy-Bart Stan, Karen M. Polizzi
Tools for engineering coordinated system behaviour in synthetic microbial consortia
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05046-2
Nature Communications 9/1 2020-02-19
2018 Marc Rullan, Dirk Benzinger, Gregor W. Schmidt, Andreas Milias-Argeitis, Mustafa Khammash
An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation
published pages: 745-756.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.04.012
Molecular Cell 70/4 2020-02-19

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "COSY-BIO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "COSY-BIO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.2.1.)

EDRA (2019)

Hardware-Assisted Decoupled Access Execution on the Digital Market: The EDRA Framework

Read More  

FLIX (2020)

FLow chemistry for Isotopic eXchange

Read More  

LABELFREE (2019)

LABEL FREE IMAGING WITH PHI-SCAT

Read More