Explore the words cloud of the COSY-BIO project. It provides you a very rough idea of what is the project "COSY-BIO" about.
The following table provides information about the project.
|Coordinator Country||Italy [IT]|
|Total cost||2˙996˙856 €|
|EC max contribution||2˙975˙345 € (99%)|
1. H2020-EU.1.2.1. (FET Open)
|Duration (year-month-day)||from 2017-10-01 to 2020-09-30|
Take a look of project's partnership.
|1||FONDAZIONE TELETHON||IT (ROMA)||coordinator||555˙875.00|
|2||IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE||UK (LONDON)||participant||568˙347.00|
|3||EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH||CH (ZUERICH)||participant||400˙000.00|
|4||THE UNIVERSITY OF EDINBURGH||UK (EDINBURGH)||participant||398˙526.00|
|5||UNIVERSITY OF BRISTOL||UK (BRISTOL)||participant||298˙196.00|
|6||UNIVERSITA DEGLI STUDI DI NAPOLI FEDERICO II||IT (NAPOLI)||participant||255˙500.00|
|7||INSTITUT NATIONAL DE RECHERCHE ENINFORMATIQUE ET AUTOMATIQUE||FR (LE CHESNAY CEDEX)||participant||250˙000.00|
|8||UNIVERSITE DE PARIS||FR (PARIS)||participant||248˙900.00|
|9||UNIVERSITE PARIS DIDEROT - PARIS 7||FR (PARIS)||participant||0.00|
Synthetic Biology aims at rational engineering of living organisms to improve human well-being and environmental sustainability, thus promising a paradigm shift in human technology. Its full potential has not been achieved yet because of the complexity of engineering biological systems where basic biological parts are intrinsically noisy and not modular. The overarching goal of COSY-BIO is to develop a theoretical framework and innovative technological tools to engineer reliable biological systems that are robust despite their individual components being not by translating principles of control engineering to molecular and cell biology. Automatic control is a well-established engineering discipline to build “controllers” to steer the dynamic behaviour of a physical system in a desired fashion. By building upon control engineering for physical systems and by exploiting the unique features of living organisms, this project will identify generally applicable approaches to design closed-loop feedback controllers for biological systems. To handle biological complexity, the project will explore three strategies of increasing difficulty “external” controllers, “embedded” controllers and “multi-cellular” controllers. External controllers will be implemented in a computer acting on cells using small molecules via microfluidics devices. Embedded controllers will be made from biological parts and integrated within individual cells to steer their behaviour. Multicellular controllers envisage two cell populations, one made up of cells with embedded controllers (controller cells) and the other will be the controlled population (target cells). In addition, a rapid prototyping platform will enable to speed up the design-build-test cycles by means of optimal experimental design, microfluidics and cell-free systems. Proof-of-principles demonstrations in bacteria and yeast with relevance to biotechnology will be tackled to prove the usefulness of this revolutionary technology.
|Detailed Dissemination and Exploitation plan||Open Research Data Pilot||2020-02-19 08:19:36|
|Comparison of model identification strategies||Documents, reports||2020-02-19 08:19:36|
|Constructing and testing of reporters of the cell cycle||Demonstrators, pilots, prototypes||2020-02-19 08:19:36|
|Official Logo of COSY-BIO||Other||2020-02-19 08:19:36|
|Data Management plan||Open Research Data Pilot||2020-02-19 08:19:36|
|Website and intranet portal||Other||2020-02-19 08:19:36|
Take a look to the deliverables list in detail: detailed list of COSY-BIO deliverables.
|year||authors and title||journal||last update|
Gabriele Lillacci, Yaakov Benenson, Mustafa Khammash
Synthetic control systems for high performance gene expression in mammalian cells
published pages: 9855-9863, ISSN: 0305-1048, DOI: 10.1093/nar/gky795
|Nucleic Acids Research 46/18||2020-02-19|
Lucia Bandiera, Zhaozheng Hou, Varun Kothamachu, Eva Balsa-Canto, Peter Swain, Filippo Menolascina
On-Line Optimal Input Design Increases the Efficiency and Accuracy of the Modelling of an Inducible Synthetic Promoter
published pages: 148, ISSN: 2227-9717, DOI: 10.3390/pr6090148
Nicolas Kylilis, Zoltan A. Tuza, Guy-Bart Stan, Karen M. Polizzi
Tools for engineering coordinated system behaviour in synthetic microbial consortia
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-05046-2
|Nature Communications 9/1||2020-02-19|
Marc Rullan, Dirk Benzinger, Gregor W. Schmidt, Andreas Milias-Argeitis, Mustafa Khammash
An Optogenetic Platform for Real-Time, Single-Cell Interrogation of Stochastic Transcriptional Regulation
published pages: 745-756.e6, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2018.04.012
|Molecular Cell 70/4||2020-02-19|
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