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EVOSOM SIGNED

Evolution of multicellularity and somatic cell specialization

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EVOSOM project word cloud

Explore the words cloud of the EVOSOM project. It provides you a very rough idea of what is the project "EVOSOM" about.

changed    function    diversification    fundamental    transitions    conserved    appearing    somatic    promoter    causality    organisation    elaboration    immense    vice    expression    proteins    found    subdivided    signal    alternatively    phenotyping    emergence    genetic    structures    caused    splice    families    allowed    tissues    propagation    spliced    esps    secreted    overexpress    10    altered    relatives    patterns    hypothesis    yielding    cells    gain    transition    group    gene    seek    multicellular    contain    intracellular    tractable    versa    dictyostelia    mostly    signalling    place    induce    amoebozoa    indicative    starting    ancestral    encoding    enabled    events    unicellular    promoters    genetically    esp    lineage    cell    organs    innovation    questions    retrace    drivers    exposed    evolution    multicellularity    specialization    genes    populations    mechanisms    induces    groups    replacement    correlations    types    frequently    functions    alternative    utr    regulatory    species    forms   

Project "EVOSOM" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF DUNDEE 

Organization address
address: Nethergate
city: DUNDEE
postcode: DD1 4HN
website: www.dundee.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙128˙602 €
 EC max contribution 2˙128˙602 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2022-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF DUNDEE UK (DUNDEE) coordinator 2˙128˙602.00

Map

 Project objective

The evolution of multicellularity allowed specialization of cells into functions that support rather than cause propagation. While yielding immense gain of function, the organisation of these somatic cells into tissues and organs required novel cell-cell signalling systems. We seek to identify the genetic changes that caused transitions to multicellularity and enabled cell specialization. We use genetically tractable Dictyostelia with multicellular structures that contain from 1 to 5 cell-types to address these fundamental questions. Dictyostelia evolved from unicellular Amoebozoa and are subdivided into 4 major groups, with most novel cell-types appearing in group 4. We found that gene expression patterns changed most frequently at the transition between groups 3 and 4, and that across groups ~10% of genes were alternatively spliced in the 5’UTR, indicative of promoter elaboration. Among known genes essential for multicellular development, those involved in intracellular signal processing were mostly conserved between Dictyostelia and unicellular Amoebozoa, while those encoding exposed and secreted proteins (ESPs) were unique to Dictyostelia or groups within Dictyostelia. Starting from a hypothesis that diversification of ESPs and gene regulatory mechanisms are major drivers of multicellular evolution, we will place unicellular relatives of Dictyostelia under selection to induce multicellularity, establish which genes are most changed in evolved populations and whether this involves ESP families that are also most changed in Dictyostelia. We will overexpress altered genes in unicellular forms to assess whether this induces multicellularity. We will retrace evolution of cell specialization by lineage analysis and phenotyping and seek correlations between cell-type innovation and alternative splice events and with emergence of novel signalling genes. Causality will be assessed by replacement of genes or promoters with ancestral forms in evolved species and vice versa

 Publications

year authors and title journal last update
List of publications.
2018 Yoshinori Kawabe, Takahiro Morio, Yoshimasa Tanaka, Pauline Schaap
Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia
published pages: , ISSN: 2041-9139, DOI: 10.1186/s13227-018-0101-6
EvoDevo 9/1 2020-01-28
2019 YOSHINORI KAWABE, QINGYOU DU, CHRISTINA SCHILDE and PAULINE SCHAAP
Evolution of multicellularity in Dictyostelia
published pages: 359-369, ISSN: 0214-6282, DOI: 10.1387/ijdb.190108ps
Int. J. Dev. Biol. 63 2020-01-28
2019 Gillian Forbes, Zhi-hui Chen, Koryu Kin, Hajara M. Lawal, Christina Schilde, Yoko Yamada, Pauline Schaap
Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-019-6239-3
BMC Genomics 20/1 2020-01-28
2018 Pauline Schaap, Christina Schilde
Encystation: the most prevalent and underinvestigated differentiation pathway of eukaryotes
published pages: 727-739, ISSN: 1350-0872, DOI: 10.1099/mic.0.000653
Microbiology 164/5 2019-05-16
2018 Koryu Kin, Gillian Forbes, Andrew Cassidy, Pauline Schaap
Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-5146-3
BMC Genomics 19/1 2019-05-16
2018 Falk Hillmann, Gillian Forbes, Silvia Novohradská, Iuliia Ferling, Konstantin Riege, Marco Groth, Martin Westermann, Manja Marz, Thomas Spaller, Thomas Winckler, Pauline Schaap, Gernot Glöckner
Multiple Roots of Fruiting Body Formation in Amoebozoa
published pages: 591-606, ISSN: 1759-6653, DOI: 10.1093/gbe/evy011
Genome Biology and Evolution 10/2 2019-05-16

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