Explore the words cloud of the EVOSOM project. It provides you a very rough idea of what is the project "EVOSOM" about.
The following table provides information about the project.
UNIVERSITY OF DUNDEE
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙128˙602 €|
|EC max contribution||2˙128˙602 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-05-01 to 2022-04-30|
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|1||UNIVERSITY OF DUNDEE||UK (DUNDEE)||coordinator||2˙128˙602.00|
The evolution of multicellularity allowed specialization of cells into functions that support rather than cause propagation. While yielding immense gain of function, the organisation of these somatic cells into tissues and organs required novel cell-cell signalling systems. We seek to identify the genetic changes that caused transitions to multicellularity and enabled cell specialization. We use genetically tractable Dictyostelia with multicellular structures that contain from 1 to 5 cell-types to address these fundamental questions. Dictyostelia evolved from unicellular Amoebozoa and are subdivided into 4 major groups, with most novel cell-types appearing in group 4. We found that gene expression patterns changed most frequently at the transition between groups 3 and 4, and that across groups ~10% of genes were alternatively spliced in the 5’UTR, indicative of promoter elaboration. Among known genes essential for multicellular development, those involved in intracellular signal processing were mostly conserved between Dictyostelia and unicellular Amoebozoa, while those encoding exposed and secreted proteins (ESPs) were unique to Dictyostelia or groups within Dictyostelia. Starting from a hypothesis that diversification of ESPs and gene regulatory mechanisms are major drivers of multicellular evolution, we will place unicellular relatives of Dictyostelia under selection to induce multicellularity, establish which genes are most changed in evolved populations and whether this involves ESP families that are also most changed in Dictyostelia. We will overexpress altered genes in unicellular forms to assess whether this induces multicellularity. We will retrace evolution of cell specialization by lineage analysis and phenotyping and seek correlations between cell-type innovation and alternative splice events and with emergence of novel signalling genes. Causality will be assessed by replacement of genes or promoters with ancestral forms in evolved species and vice versa
|year||authors and title||journal||last update|
Yoshinori Kawabe, Takahiro Morio, Yoshimasa Tanaka, Pauline Schaap
Glycogen synthase kinase 3 promotes multicellular development over unicellular encystation in encysting Dictyostelia
published pages: , ISSN: 2041-9139, DOI: 10.1186/s13227-018-0101-6
YOSHINORI KAWABE, QINGYOU DU, CHRISTINA SCHILDE and PAULINE SCHAAP
Evolution of multicellularity in Dictyostelia
published pages: 359-369, ISSN: 0214-6282, DOI: 10.1387/ijdb.190108ps
|Int. J. Dev. Biol. 63||2020-01-28|
Gillian Forbes, Zhi-hui Chen, Koryu Kin, Hajara M. Lawal, Christina Schilde, Yoko Yamada, Pauline Schaap
Phylogeny-wide conservation and change in developmental expression, cell-type specificity and functional domains of the transcriptional regulators of social amoebas
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-019-6239-3
|BMC Genomics 20/1||2020-01-28|
Pauline Schaap, Christina Schilde
Encystation: the most prevalent and underinvestigated differentiation pathway of eukaryotes
published pages: 727-739, ISSN: 1350-0872, DOI: 10.1099/mic.0.000653
Koryu Kin, Gillian Forbes, Andrew Cassidy, Pauline Schaap
Cell-type specific RNA-Seq reveals novel roles and regulatory programs for terminally differentiated Dictyostelium cells
published pages: , ISSN: 1471-2164, DOI: 10.1186/s12864-018-5146-3
|BMC Genomics 19/1||2019-05-16|
Falk Hillmann, Gillian Forbes, Silvia NovohradskÃ¡, Iuliia Ferling, Konstantin Riege, Marco Groth, Martin Westermann, Manja Marz, Thomas Spaller, Thomas Winckler, Pauline Schaap, Gernot GlÃ¶ckner
Multiple Roots of Fruiting Body Formation in Amoebozoa
published pages: 591-606, ISSN: 1759-6653, DOI: 10.1093/gbe/evy011
|Genome Biology and Evolution 10/2||2019-05-16|
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