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GENDOSIS

GENOTYPE - ENDOPHENOTYPE ASSOCIATIONS IN PSYCHOSIS

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 GENDOSIS project word cloud

Explore the words cloud of the GENDOSIS project. It provides you a very rough idea of what is the project "GENDOSIS" about.

environment    agents    course    excellent    strategy    disorders    career    limitations    ucl    psychotic    molecular    association    me    researcher    relatives    shed    subtype    bramon    construction    classifier    supervision    linkage    maps    genotypic    health    poor    training    levels    dataset    learning    coupling    mechanisms    gathered    heritability    translated    generating    secondary    ineffective    potentially    psychosis    million    burden    disease    controls    relieving    transferable    30    network    inform    therapeutic    individuals    population    independent    final    safe    big    patients    stratification    endophenotypic    genotype    genetic    light    therapeutics    scientific    acquire    variants    perform    subtypes    unrelated    launch    unaffected    genome    pathogenesis    relation    skills    unsupervised    heterogeneity    patient    genetics    impose    mapping    dr    urgent    clustering    fed    shows    data    endophenotype    machine    drugs   

Project "GENDOSIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.ucl.ac.uk/psychiatry/research/mental-health-neuroscience-department
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-07-15   to  2019-07-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Psychotic disorders impose an increasing burden on the health of the European population, with an estimated five million affected individuals. As available drugs remain ineffective for 30% of the patients and come with many secondary effects, there is urgent need to develop effective and safe therapeutic agents. Due to the high heritability of psychotic disorders, genetics shows great potential to inform the molecular mechanisms behind their pathogenesis. However, the information we have gathered on psychosis genetics has not translated into improved therapeutics yet, due to, among other reasons, two big limitations: poor knowledge of the mechanisms behind the genetics – psychosis relation and high levels of heterogeneity at the molecular level in the patient population. The research program we present aims at relieving the burden of these limitations using a genotype – endophenotype mapping strategy to shed light on disease mechanisms and identify genetic variants to be used in a patient-stratification analysis. Using a large dataset of psychosis patients, unaffected relatives and unrelated controls with genotypic and endophenotypic data we will perform a comprehensive genotype – endophenotype mapping through genome-wide linkage and association analyses. The results of the mapping will be fed into a patient stratification strategy coupling unsupervised clustering with a machine-learning construction of a classifier. The final objective is to identify genetic subtypes of psychosis, provide a classifier for these subtypes and build subtype-specific genotype – endophenotype association maps. This potentially high-impact result-generating research program, along with a five-course training program, Dr. Bramon’s supervision and the excellent research environment provided by UCL, will allow me to acquire the scientific and transferable skills and build the collaboration network necessary to launch my career as an independent researcher.

 Publications

year authors and title journal last update
List of publications.
2019 Haritz Irizar, Johan Hilge Thygesen, Eirini Zartaloudi, Anjali Bhat, Isabelle Austin-Zimmerman, Jasmine Harju-Seppänen, Maria Stella Calafato, Robin Murray, Colm McDonald, Neeltje EM van Haren, Elvira Bramon
LARGE AND RARE GENOMIC DELETIONS ARE ASSOCIATED WITH ENLARGED LATERAL VENTRICLES
published pages: S1126-S1127, ISSN: , DOI:
European Neuropsychopharmacology Volume 29, Supplement 4 2020-01-29
2019 Johan Hilge Thygesen (PhD), Amelia Presman (MSc), Jasmine Harju-Seppänen (MSc), Stella Calafato (PhD), Eirini Zartaloudi (MSc), Haritz Irizar (PhD), Rebecca Jones (MSc), Siri Ranlund (PhD), Karoline Kuchenbaecker (PhD), Kuang Lin (PhD), Wiepke Cahn (PhD) , Benedicto Crespo-Facorro (PhD), Sonja M C de Zwarte (MSc), Álvaro Díez (PhD), Marta Di Forti (PhD), GROUP, Conrad Iyegbe (PhD), Assen Jablen
Genetic Copy Number Variants, Cognition and Psychosis: A Meta-analysis and a Study of Families with Psychosis
published pages: , ISSN: 1359-4184, DOI:
Molecular Psychiatry 2020-01-29
2019 Johan Thygesen, Amelia Presman, Stella Calafato, Jasmine Harju-Seppänen, Eirini Zartaloudi, Haritz Irizar, Wiepke Cahn, GROUP Consortium, Assen Jablensky, Eugenia Kravariti, Andrew McIntosh, Dan Rujescu, Timothea Toulopoulou, Robin Murray, Elvira Bramon
EFFECTS OF COPY NUMBER VARIANTS ON COGNITION: A META-ANALYSIS AND FAMILY STUDY
published pages: S1141, ISSN: , DOI:
European Neuropsychopharmacology Volume 29, Supplement 4 2020-01-29
2019 Eirini Zartaloudi, Johan Hilge Thygesen, Aritz Irizar, Stella Calafato, Andrew McQuillin, Jasmine Harju-Seppanen, IsabelleAustin-Zimmerman, Anjali Bhat, Robin Murray, Elvira Bramon
POLYGENIC RISK SCORE AND CNV BURDEN INFLUENCES ON BROADLY AND NARROWLY DEFINED PSYCHOSIS
published pages: S1329, ISSN: , DOI:
European Neuropsychopharmacology Volume 29, Supplement 4 2020-01-29

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