Opendata, web and dolomites

GENDOSIS

GENOTYPE - ENDOPHENOTYPE ASSOCIATIONS IN PSYCHOSIS

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 GENDOSIS project word cloud

Explore the words cloud of the GENDOSIS project. It provides you a very rough idea of what is the project "GENDOSIS" about.

machine    network    dr    unsupervised    fed    career    independent    excellent    gathered    perform    learning    mapping    big    mechanisms    relatives    clustering    training    30    supervision    final    strategy    maps    genotypic    me    endophenotype    course    therapeutics    light    endophenotypic    translated    safe    patient    unrelated    relieving    genotype    environment    disease    individuals    million    transferable    scientific    coupling    generating    patients    agents    dataset    relation    subtypes    inform    unaffected    launch    urgent    data    pathogenesis    heterogeneity    poor    acquire    secondary    population    drugs    genetic    potentially    classifier    limitations    burden    stratification    association    psychosis    skills    levels    impose    genome    health    psychotic    molecular    variants    disorders    researcher    construction    subtype    shows    controls    linkage    ucl    bramon    shed    heritability    therapeutic    genetics    ineffective   

Project "GENDOSIS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY COLLEGE LONDON 

Organization address
address: GOWER STREET
city: LONDON
postcode: WC1E 6BT
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www.ucl.ac.uk/psychiatry/research/mental-health-neuroscience-department
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2017
 Duration (year-month-day) from 2017-07-15   to  2019-07-14

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY COLLEGE LONDON UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Psychotic disorders impose an increasing burden on the health of the European population, with an estimated five million affected individuals. As available drugs remain ineffective for 30% of the patients and come with many secondary effects, there is urgent need to develop effective and safe therapeutic agents. Due to the high heritability of psychotic disorders, genetics shows great potential to inform the molecular mechanisms behind their pathogenesis. However, the information we have gathered on psychosis genetics has not translated into improved therapeutics yet, due to, among other reasons, two big limitations: poor knowledge of the mechanisms behind the genetics – psychosis relation and high levels of heterogeneity at the molecular level in the patient population. The research program we present aims at relieving the burden of these limitations using a genotype – endophenotype mapping strategy to shed light on disease mechanisms and identify genetic variants to be used in a patient-stratification analysis. Using a large dataset of psychosis patients, unaffected relatives and unrelated controls with genotypic and endophenotypic data we will perform a comprehensive genotype – endophenotype mapping through genome-wide linkage and association analyses. The results of the mapping will be fed into a patient stratification strategy coupling unsupervised clustering with a machine-learning construction of a classifier. The final objective is to identify genetic subtypes of psychosis, provide a classifier for these subtypes and build subtype-specific genotype – endophenotype association maps. This potentially high-impact result-generating research program, along with a five-course training program, Dr. Bramon’s supervision and the excellent research environment provided by UCL, will allow me to acquire the scientific and transferable skills and build the collaboration network necessary to launch my career as an independent researcher.

 Publications

year authors and title journal last update
List of publications.
2019 Haritz Irizar, Johan Hilge Thygesen, Eirini Zartaloudi, Anjali Bhat, Isabelle Austin-Zimmerman, Jasmine Harju-Seppänen, Maria Stella Calafato, Robin Murray, Colm McDonald, Neeltje EM van Haren, Elvira Bramon
LARGE AND RARE GENOMIC DELETIONS ARE ASSOCIATED WITH ENLARGED LATERAL VENTRICLES
published pages: S1126-S1127, ISSN: , DOI:
European Neuropsychopharmacology Volume 29, Supplement 4 2020-01-29
2019 Johan Hilge Thygesen (PhD), Amelia Presman (MSc), Jasmine Harju-Seppänen (MSc), Stella Calafato (PhD), Eirini Zartaloudi (MSc), Haritz Irizar (PhD), Rebecca Jones (MSc), Siri Ranlund (PhD), Karoline Kuchenbaecker (PhD), Kuang Lin (PhD), Wiepke Cahn (PhD) , Benedicto Crespo-Facorro (PhD), Sonja M C de Zwarte (MSc), Álvaro Díez (PhD), Marta Di Forti (PhD), GROUP, Conrad Iyegbe (PhD), Assen Jablen
Genetic Copy Number Variants, Cognition and Psychosis: A Meta-analysis and a Study of Families with Psychosis
published pages: , ISSN: 1359-4184, DOI:
Molecular Psychiatry 2020-01-29
2019 Johan Thygesen, Amelia Presman, Stella Calafato, Jasmine Harju-Seppänen, Eirini Zartaloudi, Haritz Irizar, Wiepke Cahn, GROUP Consortium, Assen Jablensky, Eugenia Kravariti, Andrew McIntosh, Dan Rujescu, Timothea Toulopoulou, Robin Murray, Elvira Bramon
EFFECTS OF COPY NUMBER VARIANTS ON COGNITION: A META-ANALYSIS AND FAMILY STUDY
published pages: S1141, ISSN: , DOI:
European Neuropsychopharmacology Volume 29, Supplement 4 2020-01-29
2019 Eirini Zartaloudi, Johan Hilge Thygesen, Aritz Irizar, Stella Calafato, Andrew McQuillin, Jasmine Harju-Seppanen, IsabelleAustin-Zimmerman, Anjali Bhat, Robin Murray, Elvira Bramon
POLYGENIC RISK SCORE AND CNV BURDEN INFLUENCES ON BROADLY AND NARROWLY DEFINED PSYCHOSIS
published pages: S1329, ISSN: , DOI:
European Neuropsychopharmacology Volume 29, Supplement 4 2020-01-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "GENDOSIS" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "GENDOSIS" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

MingleIFT (2020)

Multi-color and single-molecule fluorescence imaging of intraflagellar transport in the phasmid chemosensory cilia of C. Elegans

Read More  

STOPFIRE (2019)

Emergency Decision Support System of Offshore Platform Fires

Read More