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An Integrated Heart Model for the simulation of the cardiac function

Total Cost €


EC-Contrib. €






 iHEART project word cloud

Explore the words cloud of the iHEART project. It provides you a very rough idea of what is the project "iHEART" about.

heart    coupling    force    convergence    pdes    community    devise    surgeons    scalable    quantitative    treatment    deaths    cardiologists    approximate    generation    preconditioners    45    stability    lifeheart    adaptive    valve    optimal    numerical    partial    groundbreaking    cardiovascular    solid    life    made    multiscale    approximation    equations    human    mathematics    construct    iheart    develops    computational    original    paradigms    mathematical    solution    scientific    libraries    software    variability    improvements    tool    validate    ihm    powerful    mathematically    electrophysiology    successful    carry    numerically    discrete    qualitative    quantification    function    dysfunction    diagnosis    ing    rigorous    interactions    redheart    computationally    sciences    multiphysics    tremendously    differential    blood    pathologies    efficient    analyze    systemic    data    core    physical    introduce    dynamics    techniques    models    inverse    circulations    drive    pulmonary    responsible    cellular    fluid    model    clinically    featuring    microscopic    ordinary    odes    coupled    cardiac    mechanics    inspired   

Project "iHEART" data sheet

The following table provides information about the project.


Organization address
city: MILANO
postcode: 20133

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website
 Total cost 2˙351˙544 €
 EC max contribution 2˙351˙544 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    POLITECNICO DI MILANO IT (MILANO) coordinator 2˙351˙544.00


 Project objective

The goal of this project is to construct, mathematically analyze, numerically approximate, computationally solve, and validate on clinically relevant cases a mathematically-based integrated heart model (IHM) for the human cardiac function. The IHM comprises several core cardiac models – electrophysiology, solid and fluid mechanics, microscopic cellular force generation, and valve dynamics – which are then coupled and finally embedded into the systemic and pulmonary blood circulations. It is a multiscale system of Partial Differential Equations (PDEs) and Ordinary Differential Equations (ODEs) featuring multiphysics interactions among the core models.

The physical and mathematical properties of each core model and those of the even more complex integrated heart model (IHM) will be analyzed. The numerical approximation of IHM develops along several steps: introduce new high order methods for the core models, carry out their stability and convergence analysis, devise new paradigms for their numerical coupling, and construct optimal, scalable, and adaptive preconditioners for the efficient solution of the resulting large-scale discrete problems. To address data variability in clinically relevant cases, new reduced order models and efficient computational techniques will be developed also for forward and inverse uncertainty quantification problems. Two software libraries, LifeHEART and RedHEART, will be built and made available to the scientific community.

The project is original, very ambitious, mathematically inspired and rigorous, tremendously challenging, and groundbreaking. If successful, it will provide researchers from applied mathematics and life sciences, cardiologists, and cardiac surgeons with a powerful tool for both the qualitative and quantitative study of cardiac function and dysfunction. iHEART has the potential to drive improvements in diagnosis and treatment for cardiovascular pathologies that are responsible for more than 45% of deaths in Europe.


year authors and title journal last update
List of publications.
2018 Stefano Pagani, Andrea Manzoni, Alfio Quarteroni
Numerical approximation of parametrized problems in cardiac electrophysiology by a local reduced basis method
published pages: 530-558, ISSN: 0045-7825, DOI: 10.1016/j.cma.2018.06.003
Computer Methods in Applied Mechanics and Engineering 340 2019-08-29
2018 Antonello Gerbi, Luca Dede’, Alfio Quarteroni
A monolithic algorithm for the simulation of cardiac electromechanics in the human left ventricle
published pages: 1-37, ISSN: 2640-3501, DOI: 10.3934/mine.2018.1.1
Mathematics in Engineering 1/1 2019-08-06
2018 Luca Barbarotta, Simone Rossi, Luca Dedè, Alfio Quarteroni
A transmurally heterogeneous orthotropic activation model for ventricular contraction and its numerical validation
published pages: e3137, ISSN: 2040-7939, DOI: 10.1002/cnm.3137
International Journal for Numerical Methods in Biomedical Engineering 34/12 2019-08-06
2019 Alessandro Masci, Lorenzo Barone, Luca Dedè, Marco Fedele, Corrado Tomasi, Alfio Quarteroni, Cristiana Corsi
The Impact of Left Atrium Appendage Morphology on Stroke Risk Assessment in Atrial Fibrillation: A Computational Fluid Dynamics Study
published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2018.01938
Frontiers in Physiology 9 2019-08-06
2019 Luca Pegolotti, Luca Dedè, Alfio Quarteroni
Isogeometric Analysis of the electrophysiology in the human heart: Numerical simulation of the bidomain equations on the atria
published pages: 52-73, ISSN: 0045-7825, DOI: 10.1016/j.cma.2018.08.032
Computer Methods in Applied Mechanics and Engineering 343 2019-08-06

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The information about "IHEART" are provided by the European Opendata Portal: CORDIS opendata.

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