Opendata, web and dolomites


A Photothermal Lateral Flow Test for Visual Point of Care Detection

Total Cost €


EC-Contrib. €






 HOTFLOW project word cloud

Explore the words cloud of the HOTFLOW project. It provides you a very rough idea of what is the project "HOTFLOW" about.

transduction    prototyped    progress    poc    device    gold    quantification    elaboration    dual    enhanced    nanoprisms    universal    arts    policy    immunoassay    analytical    efficient    platforms    military    versatile    nanotechnology    subsequently    grand    sensing    innovative    socioeconomic    biosensing    had    almost    cancer    sensitive    immobilized    microelectronics    flow    alternatives    biosensors    functions    nitrocellulose    lateral    serve    demand    gastrointestinal    significantly    critical    exists    safety    clinical    biomolecules    time    materials    nanoplasmonics    portability    profound    transducers    diagnosis    photographic    membrane    hotflow    biosensor    strategy    tracing    environmental    rapid    point    clear    markers    care    paper    worldwide    proposing    thermosensitive    ease    inexpensive    detection    proteins    capture    food    validated    slow    tumoral    science    regulation    recognition    active    analytes    ultralow    sandwich    goes    plasmonic    expensive    vital    thermal    unreliable    erc    linked    concentration   

Project "HOTFLOW" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙293 €
 EC max contribution 149˙293 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The rapid development of cost-effective and efficient biosensors has had a profound worldwide socioeconomic impact. Advances in the fields of microelectronics, materials science and nanotechnology have been vital to the implementation of enhanced sensing platforms aimed at providing alternatives to traditional analytical methods. Further, current sensing platforms are often slow, unreliable and expensive; in particular, when ultralow concentration detection is required. Although progress in the biosensors field typically focuses on clinical point-of-care diagnosis, a clear demand exists in areas such as food safety regulation, environmental policy, military and the arts, where time, cost, portability and ease-of-use of the device are critical. The grand aim of HOTFLOW is to develop an innovative, rapid, inexpensive, versatile and sensitive thermal transduction biosensor for the ultralow detection and quantification of relevant proteins such as tumoral markers. This novel sensing technology will use detection biomolecules linked to plasmonic gold nanoprisms which serve as thermal transducers by based on a lateral flow immunoassay and a “sandwich” recognition strategy with capture biomolecules immobilized on a dual-active nitrocellulose membrane support/thermosensitive paper that subsequently functions as photographic and tracing detection element. Although the ambitious thermal sensing device proposed here will be prototyped using simple analytes, this ERC POC project goes significantly beyond the current state-of-the-art in nanoplasmonics and biosensing by proposing the development and elaboration of an almost universal paper-based thermal sensing device. This technology will be implemented and validated by applying it to a specific problem, gastrointestinal cancer diagnosis.


year authors and title journal last update
List of publications.
2017 Marta Pérez-Hernández, María Moros, Grazyna Stepien, Pablo del Pino, Sebastián Menao, Marcelo de las Heras, Maykel Arias, Scott G. Mitchell, Beatriz Pelaz, Eva M. Gálvez, Jesús M. de la Fuente, Julián Pardo
Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo
published pages: , ISSN: 1743-8977, DOI: 10.1186/s12989-017-0222-4
Particle and Fibre Toxicology 14/1 2019-05-16

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