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HOTFLOW SIGNED

A Photothermal Lateral Flow Test for Visual Point of Care Detection

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 HOTFLOW project word cloud

Explore the words cloud of the HOTFLOW project. It provides you a very rough idea of what is the project "HOTFLOW" about.

nanoplasmonics    profound    transduction    hotflow    device    cancer    membrane    efficient    biosensing    enhanced    thermosensitive    linked    diagnosis    clinical    microelectronics    validated    biomolecules    nanoprisms    innovative    ultralow    immunoassay    environmental    socioeconomic    paper    sensing    biosensor    recognition    sensitive    thermal    grand    tumoral    strategy    analytical    goes    photographic    active    safety    plasmonic    demand    tracing    clear    markers    inexpensive    analytes    versatile    almost    portability    time    nanotechnology    expensive    dual    exists    worldwide    point    ease    sandwich    transducers    lateral    subsequently    functions    military    serve    vital    food    immobilized    detection    biosensors    prototyped    regulation    alternatives    rapid    materials    universal    poc    proposing    gastrointestinal    capture    flow    gold    care    policy    critical    slow    had    platforms    concentration    unreliable    quantification    significantly    elaboration    proteins    nitrocellulose    progress    arts    erc    science   

Project "HOTFLOW" data sheet

The following table provides information about the project.

Coordinator
AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS 

Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006
website: http://www.csic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙293 €
 EC max contribution 149˙293 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS ES (MADRID) coordinator 149˙293.00

Map

 Project objective

The rapid development of cost-effective and efficient biosensors has had a profound worldwide socioeconomic impact. Advances in the fields of microelectronics, materials science and nanotechnology have been vital to the implementation of enhanced sensing platforms aimed at providing alternatives to traditional analytical methods. Further, current sensing platforms are often slow, unreliable and expensive; in particular, when ultralow concentration detection is required. Although progress in the biosensors field typically focuses on clinical point-of-care diagnosis, a clear demand exists in areas such as food safety regulation, environmental policy, military and the arts, where time, cost, portability and ease-of-use of the device are critical. The grand aim of HOTFLOW is to develop an innovative, rapid, inexpensive, versatile and sensitive thermal transduction biosensor for the ultralow detection and quantification of relevant proteins such as tumoral markers. This novel sensing technology will use detection biomolecules linked to plasmonic gold nanoprisms which serve as thermal transducers by based on a lateral flow immunoassay and a “sandwich” recognition strategy with capture biomolecules immobilized on a dual-active nitrocellulose membrane support/thermosensitive paper that subsequently functions as photographic and tracing detection element. Although the ambitious thermal sensing device proposed here will be prototyped using simple analytes, this ERC POC project goes significantly beyond the current state-of-the-art in nanoplasmonics and biosensing by proposing the development and elaboration of an almost universal paper-based thermal sensing device. This technology will be implemented and validated by applying it to a specific problem, gastrointestinal cancer diagnosis.

 Publications

year authors and title journal last update
List of publications.
2017 Marta Pérez-Hernández, María Moros, Grazyna Stepien, Pablo del Pino, Sebastián Menao, Marcelo de las Heras, Maykel Arias, Scott G. Mitchell, Beatriz Pelaz, Eva M. Gálvez, Jesús M. de la Fuente, Julián Pardo
Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo
published pages: , ISSN: 1743-8977, DOI: 10.1186/s12989-017-0222-4
Particle and Fibre Toxicology 14/1 2019-05-16

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