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A Photothermal Lateral Flow Test for Visual Point of Care Detection

Total Cost €


EC-Contrib. €






 HOTFLOW project word cloud

Explore the words cloud of the HOTFLOW project. It provides you a very rough idea of what is the project "HOTFLOW" about.

dual    linked    military    proteins    demand    proposing    analytical    goes    ultralow    subsequently    transduction    vital    validated    biomolecules    exists    tracing    environmental    efficient    safety    poc    progress    lateral    almost    nitrocellulose    functions    paper    immunoassay    had    clear    ease    thermosensitive    gold    tumoral    plasmonic    hotflow    markers    policy    biosensing    concentration    sandwich    quantification    unreliable    strategy    sensitive    biosensors    photographic    worldwide    portability    critical    socioeconomic    biosensor    transducers    rapid    time    cancer    profound    arts    significantly    nanoprisms    thermal    platforms    detection    versatile    flow    immobilized    innovative    microelectronics    science    serve    recognition    grand    active    elaboration    inexpensive    enhanced    device    sensing    erc    expensive    alternatives    analytes    prototyped    capture    materials    food    gastrointestinal    membrane    slow    regulation    nanotechnology    point    diagnosis    nanoplasmonics    universal    care    clinical   

Project "HOTFLOW" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙293 €
 EC max contribution 149˙293 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The rapid development of cost-effective and efficient biosensors has had a profound worldwide socioeconomic impact. Advances in the fields of microelectronics, materials science and nanotechnology have been vital to the implementation of enhanced sensing platforms aimed at providing alternatives to traditional analytical methods. Further, current sensing platforms are often slow, unreliable and expensive; in particular, when ultralow concentration detection is required. Although progress in the biosensors field typically focuses on clinical point-of-care diagnosis, a clear demand exists in areas such as food safety regulation, environmental policy, military and the arts, where time, cost, portability and ease-of-use of the device are critical. The grand aim of HOTFLOW is to develop an innovative, rapid, inexpensive, versatile and sensitive thermal transduction biosensor for the ultralow detection and quantification of relevant proteins such as tumoral markers. This novel sensing technology will use detection biomolecules linked to plasmonic gold nanoprisms which serve as thermal transducers by based on a lateral flow immunoassay and a “sandwich” recognition strategy with capture biomolecules immobilized on a dual-active nitrocellulose membrane support/thermosensitive paper that subsequently functions as photographic and tracing detection element. Although the ambitious thermal sensing device proposed here will be prototyped using simple analytes, this ERC POC project goes significantly beyond the current state-of-the-art in nanoplasmonics and biosensing by proposing the development and elaboration of an almost universal paper-based thermal sensing device. This technology will be implemented and validated by applying it to a specific problem, gastrointestinal cancer diagnosis.


year authors and title journal last update
List of publications.
2017 Marta Pérez-Hernández, María Moros, Grazyna Stepien, Pablo del Pino, Sebastián Menao, Marcelo de las Heras, Maykel Arias, Scott G. Mitchell, Beatriz Pelaz, Eva M. Gálvez, Jesús M. de la Fuente, Julián Pardo
Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo
published pages: , ISSN: 1743-8977, DOI: 10.1186/s12989-017-0222-4
Particle and Fibre Toxicology 14/1 2019-05-16

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