Opendata, web and dolomites


A Photothermal Lateral Flow Test for Visual Point of Care Detection

Total Cost €


EC-Contrib. €






 HOTFLOW project word cloud

Explore the words cloud of the HOTFLOW project. It provides you a very rough idea of what is the project "HOTFLOW" about.

platforms    sandwich    prototyped    paper    membrane    markers    microelectronics    strategy    care    inexpensive    subsequently    ease    grand    nitrocellulose    universal    quantification    transduction    proposing    concentration    analytes    ultralow    detection    nanotechnology    goes    had    device    portability    environmental    biosensor    arts    profound    vital    elaboration    diagnosis    biomolecules    cancer    enhanced    efficient    analytical    safety    active    immunoassay    regulation    tracing    biosensing    worldwide    versatile    nanoprisms    tumoral    nanoplasmonics    clear    erc    slow    rapid    sensitive    thermal    recognition    progress    thermosensitive    serve    expensive    hotflow    lateral    flow    exists    sensing    socioeconomic    photographic    capture    significantly    almost    validated    transducers    linked    biosensors    proteins    innovative    gold    military    point    gastrointestinal    materials    alternatives    demand    science    unreliable    functions    policy    poc    immobilized    critical    clinical    food    time    plasmonic    dual   

Project "HOTFLOW" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙293 €
 EC max contribution 149˙293 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The rapid development of cost-effective and efficient biosensors has had a profound worldwide socioeconomic impact. Advances in the fields of microelectronics, materials science and nanotechnology have been vital to the implementation of enhanced sensing platforms aimed at providing alternatives to traditional analytical methods. Further, current sensing platforms are often slow, unreliable and expensive; in particular, when ultralow concentration detection is required. Although progress in the biosensors field typically focuses on clinical point-of-care diagnosis, a clear demand exists in areas such as food safety regulation, environmental policy, military and the arts, where time, cost, portability and ease-of-use of the device are critical. The grand aim of HOTFLOW is to develop an innovative, rapid, inexpensive, versatile and sensitive thermal transduction biosensor for the ultralow detection and quantification of relevant proteins such as tumoral markers. This novel sensing technology will use detection biomolecules linked to plasmonic gold nanoprisms which serve as thermal transducers by based on a lateral flow immunoassay and a “sandwich” recognition strategy with capture biomolecules immobilized on a dual-active nitrocellulose membrane support/thermosensitive paper that subsequently functions as photographic and tracing detection element. Although the ambitious thermal sensing device proposed here will be prototyped using simple analytes, this ERC POC project goes significantly beyond the current state-of-the-art in nanoplasmonics and biosensing by proposing the development and elaboration of an almost universal paper-based thermal sensing device. This technology will be implemented and validated by applying it to a specific problem, gastrointestinal cancer diagnosis.


year authors and title journal last update
List of publications.
2017 Marta Pérez-Hernández, María Moros, Grazyna Stepien, Pablo del Pino, Sebastián Menao, Marcelo de las Heras, Maykel Arias, Scott G. Mitchell, Beatriz Pelaz, Eva M. Gálvez, Jesús M. de la Fuente, Julián Pardo
Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo
published pages: , ISSN: 1743-8977, DOI: 10.1186/s12989-017-0222-4
Particle and Fibre Toxicology 14/1 2019-05-16

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