Opendata, web and dolomites


A Photothermal Lateral Flow Test for Visual Point of Care Detection

Total Cost €


EC-Contrib. €






 HOTFLOW project word cloud

Explore the words cloud of the HOTFLOW project. It provides you a very rough idea of what is the project "HOTFLOW" about.

expensive    rapid    nanotechnology    had    concentration    nanoprisms    clinical    biomolecules    diagnosis    universal    demand    arts    functions    care    progress    unreliable    plasmonic    sensing    socioeconomic    goes    profound    hotflow    cancer    flow    biosensing    serve    analytes    lateral    gold    inexpensive    alternatives    safety    strategy    biosensor    grand    nanoplasmonics    slow    prototyped    membrane    biosensors    analytical    critical    nitrocellulose    microelectronics    active    almost    poc    exists    significantly    portability    policy    materials    immobilized    ultralow    photographic    military    subsequently    linked    erc    efficient    worldwide    platforms    sensitive    dual    elaboration    science    device    ease    proposing    vital    paper    capture    immunoassay    food    gastrointestinal    enhanced    proteins    innovative    thermosensitive    tracing    detection    regulation    markers    environmental    clear    time    validated    transduction    sandwich    tumoral    quantification    point    thermal    recognition    transducers    versatile   

Project "HOTFLOW" data sheet

The following table provides information about the project.


Organization address
address: CALLE SERRANO 117
city: MADRID
postcode: 28006

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 149˙293 €
 EC max contribution 149˙293 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-08-01   to  2019-01-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The rapid development of cost-effective and efficient biosensors has had a profound worldwide socioeconomic impact. Advances in the fields of microelectronics, materials science and nanotechnology have been vital to the implementation of enhanced sensing platforms aimed at providing alternatives to traditional analytical methods. Further, current sensing platforms are often slow, unreliable and expensive; in particular, when ultralow concentration detection is required. Although progress in the biosensors field typically focuses on clinical point-of-care diagnosis, a clear demand exists in areas such as food safety regulation, environmental policy, military and the arts, where time, cost, portability and ease-of-use of the device are critical. The grand aim of HOTFLOW is to develop an innovative, rapid, inexpensive, versatile and sensitive thermal transduction biosensor for the ultralow detection and quantification of relevant proteins such as tumoral markers. This novel sensing technology will use detection biomolecules linked to plasmonic gold nanoprisms which serve as thermal transducers by based on a lateral flow immunoassay and a “sandwich” recognition strategy with capture biomolecules immobilized on a dual-active nitrocellulose membrane support/thermosensitive paper that subsequently functions as photographic and tracing detection element. Although the ambitious thermal sensing device proposed here will be prototyped using simple analytes, this ERC POC project goes significantly beyond the current state-of-the-art in nanoplasmonics and biosensing by proposing the development and elaboration of an almost universal paper-based thermal sensing device. This technology will be implemented and validated by applying it to a specific problem, gastrointestinal cancer diagnosis.


year authors and title journal last update
List of publications.
2017 Marta Pérez-Hernández, María Moros, Grazyna Stepien, Pablo del Pino, Sebastián Menao, Marcelo de las Heras, Maykel Arias, Scott G. Mitchell, Beatriz Pelaz, Eva M. Gálvez, Jesús M. de la Fuente, Julián Pardo
Multiparametric analysis of anti-proliferative and apoptotic effects of gold nanoprisms on mouse and human primary and transformed cells, biodistribution and toxicity in vivo
published pages: , ISSN: 1743-8977, DOI: 10.1186/s12989-017-0222-4
Particle and Fibre Toxicology 14/1 2019-05-16

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