Explore the words cloud of the CartiLube project. It provides you a very rough idea of what is the project "CartiLube" about.
The following table provides information about the project.
WEIZMANN INSTITUTE OF SCIENCE
|Coordinator Country||Israel [IL]|
|Total cost||2˙499˙944 €|
|EC max contribution||2˙499˙944 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-09-01 to 2022-08-31|
Take a look of project's partnership.
|1||WEIZMANN INSTITUTE OF SCIENCE||IL (REHOVOT)||coordinator||1˙901˙058.00|
|2||THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD||UK (OXFORD)||participant||598˙886.00|
Can we exploit insights from the remarkably lubricated surfaces of articular cartilage, to create lubricants that may alleviate osteoarthritis (OA), the most widespread joint disease, affecting millions? These, succinctly, are the challenges of the present proposal. They are driven by our recent finding that lubrication of destabilised joints leads to changes in gene-regulation of the cartilage-embedded chondrocytes to protect against development of the disease. OA alleviation is known to arise through orthopedically suppressing shear-stresses on the cartilage, and a central premise of this project is that, by reducing friction at the articulating cartilage through suitable lubrication, we may achieve the same beneficial effect on the disease. The objectives of this project are to better understand the origins of cartilage boundary lubrication through examination of friction-reduction by its main molecular components, and exploit that understanding to create lubricants that, on intra-articular injection, will lubricate cartilage sufficiently well to achieve alleviation of OA via gene regulation. The project will examine, via both nanotribometric and macroscopic measurements, how the main molecular species implicated in cartilage lubrication, lipids, hyaluronan and lubricin, and their combinations, act together to form optimally lubricating boundary layers on model surfaces as well as on excised cartilage. Based on this, we shall develop suitable materials to lubricate cartilage in joints, using mouse models. Lubricants will further be optimized with respect to their retention in the joint and cartilage targeting, both in model studies and in vivo. The effect of the lubricants in regulating gene expression, in reducing pain and cartilage degradation, and in promoting stem-cell adhesion to the cartilage will be studied in a mouse model in which OA has been induced. Our results will have implications for treatment of a common, debilitating disease.
|year||authors and title||journal||last update|
Weifeng Lin, Reut Mashiah, Jasmine Seror, Assaf Kadar, Oleg Dolkart, Tamir Pritsch, Ronit Goldberg, Jacob Klein
Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction
published pages: 314-321, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.11.015
|Acta Biomaterialia 83||2019-06-05|
Irit Rosenhek-Goldian, Nir Kampf, Jacob Klein
Trapped Aqueous Films Lubricate Highly Hydrophobic Surfaces
published pages: 10075-10083, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b04735
|ACS Nano 12/10||2019-06-05|
Ran Tivony, Sam Safran, Philip Pincus, Gilad Silbert, Jacob Klein
Charging dynamics of an individual nanopore
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06364-1
|Nature Communications 9/1||2019-06-05|
Sabrina Jahn, Jacob Klein
Lubrication of articular cartilage
published pages: 48-54, ISSN: 0031-9228, DOI: 10.1063/pt.3.3898
|Physics Today 71/4||2019-06-05|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CARTILUBE" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (firstname.lastname@example.org) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "CARTILUBE" are provided by the European Opendata Portal: CORDIS opendata.