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CartiLube SIGNED

Lubricating Cartilage: exploring the relation between lubrication and gene-regulation to alleviate osteoarthritis

Total Cost €

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EC-Contrib. €

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Partnership

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Project "CartiLube" data sheet

The following table provides information about the project.

Coordinator
WEIZMANN INSTITUTE OF SCIENCE 

Organization address
address: HERZL STREET 234
city: REHOVOT
postcode: 7610001
website: www.weizmann.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 2˙499˙944 €
 EC max contribution 2˙499˙944 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    WEIZMANN INSTITUTE OF SCIENCE IL (REHOVOT) coordinator 1˙901˙058.00
2    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 598˙886.00

Map

 Project objective

Can we exploit insights from the remarkably lubricated surfaces of articular cartilage, to create lubricants that may alleviate osteoarthritis (OA), the most widespread joint disease, affecting millions? These, succinctly, are the challenges of the present proposal. They are driven by our recent finding that lubrication of destabilised joints leads to changes in gene-regulation of the cartilage-embedded chondrocytes to protect against development of the disease. OA alleviation is known to arise through orthopedically suppressing shear-stresses on the cartilage, and a central premise of this project is that, by reducing friction at the articulating cartilage through suitable lubrication, we may achieve the same beneficial effect on the disease. The objectives of this project are to better understand the origins of cartilage boundary lubrication through examination of friction-reduction by its main molecular components, and exploit that understanding to create lubricants that, on intra-articular injection, will lubricate cartilage sufficiently well to achieve alleviation of OA via gene regulation. The project will examine, via both nanotribometric and macroscopic measurements, how the main molecular species implicated in cartilage lubrication, lipids, hyaluronan and lubricin, and their combinations, act together to form optimally lubricating boundary layers on model surfaces as well as on excised cartilage. Based on this, we shall develop suitable materials to lubricate cartilage in joints, using mouse models. Lubricants will further be optimized with respect to their retention in the joint and cartilage targeting, both in model studies and in vivo. The effect of the lubricants in regulating gene expression, in reducing pain and cartilage degradation, and in promoting stem-cell adhesion to the cartilage will be studied in a mouse model in which OA has been induced. Our results will have implications for treatment of a common, debilitating disease.

 Publications

year authors and title journal last update
List of publications.
2019 Weifeng Lin, Reut Mashiah, Jasmine Seror, Assaf Kadar, Oleg Dolkart, Tamir Pritsch, Ronit Goldberg, Jacob Klein
Lipid-hyaluronan synergy strongly reduces intrasynovial tissue boundary friction
published pages: 314-321, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2018.11.015
Acta Biomaterialia 83 2019-06-05
2018 Irit Rosenhek-Goldian, Nir Kampf, Jacob Klein
Trapped Aqueous Films Lubricate Highly Hydrophobic Surfaces
published pages: 10075-10083, ISSN: 1936-0851, DOI: 10.1021/acsnano.8b04735
ACS Nano 12/10 2019-06-05
2018 Ran Tivony, Sam Safran, Philip Pincus, Gilad Silbert, Jacob Klein
Charging dynamics of an individual nanopore
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06364-1
Nature Communications 9/1 2019-06-05
2018 Sabrina Jahn, Jacob Klein
Lubrication of articular cartilage
published pages: 48-54, ISSN: 0031-9228, DOI: 10.1063/pt.3.3898
Physics Today 71/4 2019-06-05

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The information about "CARTILUBE" are provided by the European Opendata Portal: CORDIS opendata.

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