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UbiCODE SIGNED

European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets

Total Cost €

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EC-Contrib. €

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Partnership

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 UbiCODE project word cloud

Explore the words cloud of the UbiCODE project. It provides you a very rough idea of what is the project "UbiCODE" about.

intricate    interestingly    levels    unprecedented    code    protein    therapeutic    infections    modification    acetylation    compartment    laquo    latest    time    neurodegeneration    heterologous    manner    equilibrium    industry    defects    ubl    essential    effort    ways    efficient    cell    clinical    expanded    function    discovery    status    ptm    stability    biochemical    decrypt    collaborative    modify    proteins    interaction    multidisciplinary    explore    language    modified    fundamental    nedd8    unknown    unsuspected    family    universal    ub    right    enzymes    model    interconnected    cancer    molecules    area    themselves    regulation    complexity    homeostatic    pharmacological    translational    chemical    members    joint    pharmaceutical    modifications    intervention    molecular    deciphered    organisms    phosphorylation    homeostasis    technological    cellular    inflammation    raquo    understand    pathologies    hold    efforts    ubicode    scientists    ubiquitin    post    ptms    landscape    attractive    chains    regulate    multiple    forming    localisation    sumo   

Project "UbiCODE" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 3˙407˙194 €
 EC max contribution 3˙407˙194 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-ETN
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 525˙751.00
2    UNIVERSITY OF DUNDEE UK (DUNDEE) participant 546˙575.00
3    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 510˙748.00
4    NOVO NORDISK A/S DK (BAGSVAERD) participant 290˙081.00
5    THE UNIVERSITY OF LIVERPOOL UK (LIVERPOOL) participant 273˙287.00
6    FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH FONDATION CH (BASEL) participant 265˙226.00
7    INSTITUT FUR MOLEKULARE BIOLOGIE GGMBH DE (MAINZ) participant 249˙216.00
8    JOHANN WOLFGANG GOETHE-UNIVERSITATFRANKFURT AM MAIN DE (FRANKFURT AM MAIN) participant 249˙216.00
9    MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV DE (MUENCHEN) participant 249˙216.00
10    ASOCIACION CENTRO DE INVESTIGACION COOPERATIVA EN BIOCIENCIAS ES (DERIO VIZCAYA) participant 247˙872.00
11    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 0.00
12    Basque Country University ES (Leioa) partner 0.00
13    Hybrigenics FR (PARIS) partner 0.00
14    Merck KGaA DE (DARMSTADT) partner 0.00
15    Nova Medical School PT (Lisboa) partner 0.00
16    Novartis CH (Basel) partner 0.00
17    The Naked Scientists Ltd UK (Cambridge) partner 0.00
18    UbiQ NL (AMSTERDAM) partner 0.00
19    Ubiquigent Ltd UK (Dundee) partner 0.00
20    YELLOW RESEARCH NL (AMSTERDAM) partner 0.00

Map

 Project objective

Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE represents an unprecedented effort to understand this code in an integrated manner.

 Deliverables

List of deliverables.
Supervisory Board Other 2020-04-16 14:16:31
Outreach and research article publications, meetings, events Documents, reports 2020-04-16 14:16:26
UbiCODE website launched and updated and presence in social media Websites, patent fillings, videos etc. 2020-04-16 14:16:21

Take a look to the deliverables list in detail:  detailed list of UbiCODE deliverables.

 Publications

year authors and title journal last update
List of publications.
2020 Zuzanna Kozicka, Georg Petzold, Nicolas H. Thomä
Taking the Brakes Off Targeted Protein Degradation
published pages: 16-18, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2019.12.010
Cell Chemical Biology 27/1 2020-02-05
2020 David A. Pérez Berrocal, Katharina F. Witting, Huib Ovaa, Monique P. C. Mulder
Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code
published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00931
Frontiers in Chemistry 7 2020-02-04

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The information about "UBICODE" are provided by the European Opendata Portal: CORDIS opendata.

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