UbiCODE SIGNED
European Research Training to Decipher The Ub Code : identification of potential biomarkers and drug targets
Total Cost €
0EC-Contrib. €
0Partnership
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Project "UbiCODE" data sheet
The following table provides information about the project.
| Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 3˙407˙194 € |
| EC max contribution | 3˙407˙194 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2017 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-01-01 to 2021-12-31 |
Partnership
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Project objective
Essential role of protein modification by members of the Ubiquitin family: Post-translational modifications (PTM) by members of the Ubiquitin (Ub) family represent an efficient way to regulate protein function at several levels: to change their localisation, activity, their interaction with partner proteins or their stability at the right time and cellular compartment, according to the cell requirements. Defects in this homeostatic equilibrium result in pathologies such as cancer, neurodegeneration, inflammation or multiple infections. For this reason, this research area has become very attractive for fundamental scientists as well as for the pharmaceutical industry aiming to identify potential targets for therapeutic intervention. Ub family members hold a homeostatic equilibrium within the cell and are interconnected in various ways including the regulation of enzymes that control the modified status of target proteins. Interestingly, Ub and Ub-like (UbL) proteins can modify themselves, forming intricate and complex chains. This landscape has recently expanded with the discovery of the formation of heterologous chains among UbL molecules including SUMO or NEDD8 but also other PTMs such as phosphorylation or acetylation. This unsuspected complexity of what is now known as the «Ubiquitin Code», which is an unknown universal language that needs to be deciphered to understand protein homeostasis and its associated pathologies. To decrypt this complex code requires joint collaborative multidisciplinary efforts at all levels, including the use of distinct molecular systems and model organisms and the latest technological developments to explore chemical, biochemical, molecular, pharmacological and clinical aspects of protein modification by members of the Ub family. UbiCODE represents an unprecedented effort to understand this code in an integrated manner.
Deliverables
| Supervisory Board | Other | 2020-04-16 14:16:31 |
| Outreach and research article publications, meetings, events | Documents, reports | 2020-04-16 14:16:26 |
| UbiCODE website launched and updated and presence in social media | Websites, patent fillings, videos etc. | 2020-04-16 14:16:21 |
Take a look to the deliverables list in detail: detailed list of UbiCODE deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Zuzanna Kozicka, Georg Petzold, Nicolas H. Thomä Taking the Brakes Off Targeted Protein Degradation published pages: 16-18, ISSN: 2451-9456, DOI: 10.1016/j.chembiol.2019.12.010 |
Cell Chemical Biology 27/1 | 2020-02-05 |
| 2020 |
David A. Pérez Berrocal, Katharina F. Witting, Huib Ovaa, Monique P. C. Mulder Hybrid Chains: A Collaboration of Ubiquitin and Ubiquitin-Like Modifiers Introducing Cross-Functionality to the Ubiquitin Code published pages: , ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00931 |
Frontiers in Chemistry 7 | 2020-02-04 |
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