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Tracing Evolution of Auxin Transport and Polarity in Plants

Total Cost €


EC-Contrib. €






 ETAP project word cloud

Explore the words cloud of the ETAP project. It provides you a very rough idea of what is the project "ETAP" about.

outcome    deeper    approaching    multicellular    unsolved    combining    intellectual    eukaryotes    feasibility    determines    transporters    endocytic    dependent    questions    subcellular    origin    independently    deal    ins    directional    organism    plant    structure    methodological    obvious    multicellularity    cell    direction    despite    goals    models    tissues    structural    interdisciplinary    motifs    trafficking    entry    prokaryotic    components    plants    model    mechanisms    genetic    diversification    polarity    auxin    lower    directionality    localization    promises    regulations    evolution    alternative    programs    preliminary    functional    vesicle    pin    perspective    interesting    limits    transport    polar    opportunity    land    basic    provides    limitations    lineage    flow    biological    developmental    conserved    life    link    regulatory    module    fronts    cellular    decades    ancestral    strategy    insights    intensive    start    overcome    hormone    specification    urgently    evolutionary    plug    subject    gain    promise    characterization   

Project "ETAP" data sheet

The following table provides information about the project.


Organization address
address: Am Campus 1
postcode: 3400

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Project website
 Total cost 2˙410˙292 €
 EC max contribution 2˙410˙292 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Multicellularity in plants evolved independently from other eukaryotes and presents a unique, alternative way how to deal with challenges of life. A major plant developmental module is the directional transport for the plant hormone auxin. The crucial components are PIN auxin transporters, whose polar, subcellular localization determines directionality of auxin flow through tissues. PIN-dependent auxin transport represents a unique model for studying the functional link between basic cellular processes, such as vesicle trafficking and cell polarity, and their developmental outcome at the level of the multicellular organism. Despite decades of intensive research, the classical approaches in the established models are approaching their limits and many crucial questions remain unsolved, in particular related to PIN structure, regulatory motifs and evolutionary origin I propose to start a new direction in my research using an evolutionary perspective. This promises to overcome current limitations and provides not only (i) interesting insights into PIN evolution and diversification, but also (ii) a unique opportunity to study how evolutionary conserved cellular mechanisms of e.g. endocytic trafficking evolved specific plug-ins to make them subject to plant-specific regulations. The characterization of (iii) prokaryotic PIN origin will provide a so urgently needed (iv) entry into PIN structural studies. To achieve these goals, we will also establish novel (v) genetic and cell biological models in the ancestral lineage of the land plants that will be of a great use for any plant evolutionary studies. The intellectual and methodological challenges of such interdisciplinary strategy combining several lower and higher plant models are obvious, but our preliminary results at several fronts promise its feasibility and success to gain deeper understanding of exciting questions on evolution and mechanisms behind the coordination and specification of developmental programs.


year authors and title journal last update
List of publications.
2019 Matouš Glanc, Matyáš Fendrych, Jiří Friml
PIN2 Polarity Establishment in Arabidopsis in the Absence of an Intact Cytoskeleton
published pages: 222, ISSN: 2218-273X, DOI: 10.3390/biom9060222
Biomolecules 9/6 2020-03-24
2018 Urszula Kania, Tomasz Nodzyński, Qing Lu, Glenn R. Hicks, Wim Nerinckx, Kiril Mishev, François Peurois, Jacqueline Cherfils, Riet De Rycke, Peter Grones, Stéphanie Robert, Eugenia Russinova, Jiří Friml
The Inhibitor Endosidin 4 Targets SEC7 Domain-Type ARF GTPase Exchange Factors and Interferes with Subcellular Trafficking in Eukaryotes
published pages: 2553-2572, ISSN: 1040-4651, DOI: 10.1105/tpc.18.00127
The Plant Cell 30/10 2020-03-24
2018 Sander Hille, Maria Akhmanova, Matouš Glanc, Alexander Johnson, Jiří Friml
Relative Contribution of PIN-Containing Secretory Vesicles and Plasma Membrane PINs to the Directed Auxin Transport: Theoretical Estimation
published pages: 3566, ISSN: 1422-0067, DOI: 10.3390/ijms19113566
International Journal of Molecular Sciences 19/11 2020-03-24
2018 Tomoaki Nishiyama, Hidetoshi Sakayama, Jan de Vries, Henrik Buschmann, Denis Saint-Marcoux, Kristian K. Ullrich, Fabian B. Haas, Lisa Vanderstraeten, Dirk Becker, Daniel Lang, Stanislav Vosolsobě, Stephane Rombauts, Per K.I. Wilhelmsson, Philipp Janitza, Ramona Kern, Alexander Heyl, Florian Rümpler, Luz Irina A. Calderón Villalobos, John M. Clay, Roman Skokan, Atsushi Toyoda, Yutaka Suzuki, Hir
The Chara Genome: Secondary Complexity and Implications for Plant Terrestrialization
published pages: 448-464.e24, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.06.033
Cell 174/2 2020-03-24
2018 Matouš Glanc, Matyáš Fendrych, Jiří Friml
Mechanistic framework for cell-intrinsic re-establishment of PIN2 polarity after cell division
published pages: 1082-1088, ISSN: 2055-0278, DOI: 10.1038/s41477-018-0318-3
Nature Plants 4/12 2020-03-24
2019 Min Cao, Rong Chen, Pan Li, Yongqiang Yu, Rui Zheng, Danfeng Ge, Wei Zheng, Xuhui Wang, Yangtao Gu, Zuzana Gelová, Jiří Friml, Heng Zhang, Renyi Liu, Jun He, Tongda Xu
TMK1-mediated auxin signalling regulates differential growth of the apical hook
published pages: 240-243, ISSN: 0028-0836, DOI: 10.1038/s41586-019-1069-7
Nature 568/7751 2020-03-24
2019 Yuzhou Zhang, Guanghui Xiao, Xiaojuan Wang, Xixi Zhang, Jiří Friml
Evolution of fast root gravitropism in seed plants
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11471-8
Nature Communications 10/1 2020-03-24
2019 Akihiro Oochi, Jakub Hajny, Kosuke Fukui, Yukio Nakao, Michelle Gallei, Mussa Quareshy, Koji Takahashi, Toshinori Kinoshita, Sigurd Ramans Harborough, Stefan Kepinski, Hiroyuki Kasahara, Richard Napier, Jiří Friml, Ken-ichiro Hayashi
Pinstatic Acid Promotes Auxin Transport by Inhibiting PIN Internalization
published pages: 1152-1165, ISSN: 0032-0889, DOI: 10.1104/pp.19.00201
Plant Physiology 180/2 2020-03-24
2018 Matyáš Fendrych, Maria Akhmanova, Jack Merrin, Matouš Glanc, Shinya Hagihara, Koji Takahashi, Naoyuki Uchida, Keiko U. Torii, Jiří Friml
Rapid and reversible root growth inhibition by TIR1 auxin signalling
published pages: 453-459, ISSN: 2055-0278, DOI: 10.1038/s41477-018-0190-1
Nature Plants 4/7 2020-03-24
2019 Petra Marhava, Lukas Hoermayer, Saiko Yoshida, Peter Marhavý, Eva Benková, Jiří Friml
Re-activation of Stem Cell Pathways for Pattern Restoration in Plant Wound Healing
published pages: 957-969.e13, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.04.015
Cell 177/4 2020-03-24
2018 Peter Grones, Melinda Abas, Jakub Hajný, Angharad Jones, Sascha Waidmann, Jürgen Kleine-Vehn, Jiří Friml
PID/WAG-mediated phosphorylation of the Arabidopsis PIN3 auxin transporter mediates polarity switches during gravitropism
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28188-1
Scientific Reports 8/1 2020-03-24

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