METAEXPLORE

Metagenomics for bioexploration - Tools and application

 Coordinatore RIJKSUNIVERSITEIT GRONINGEN 

 Organization address address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Mr.
Nome: Jan
Cognome: Poutsma
Email: send email
Telefono: 31503634142
Fax: 31503634500

 Nazionalità Coordinatore Netherlands [NL]
 Totale costo 8˙065˙047 €
 EC contributo 5˙999˙991 €
 Programma FP7-KBBE
Specific Programme "Cooperation": Food, Agriculture and Biotechnology
 Code Call FP7-KBBE-2007-2A
 Funding Scheme CP-IP
 Anno di inizio 2009
 Periodo (anno-mese-giorno) 2009-05-01   -   2014-04-30

 Partecipanti

# participant  country  role  EC contrib. [€] 
1    RIJKSUNIVERSITEIT GRONINGEN

 Organization address address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Mr.
Nome: Jan
Cognome: Poutsma
Email: send email
Telefono: 31503634142
Fax: 31503634500

NL (GRONINGEN) coordinator 876˙780.00
2    ECOLE CENTRALE DE LYON

 Organization address address: Avenue Guy de Collongue 36
city: ECULLY CEDEX
postcode: 69131

contact info
Titolo: Dr.
Nome: Bénédicte
Cognome: Martin
Email: send email
Telefono: +33 472 18 67 08
Fax: +33 472 18 60 74

FR (ECULLY CEDEX) participant 482˙500.00
3    UNIVERSITAET BIELEFELD

 Organization address address: UNIVERSITAETSSTRASSE 25
city: BIELEFELD
postcode: 33615

contact info
Titolo: Ms.
Nome: Iris
Cognome: Litty
Email: send email
Telefono: +49 521 106 2569
Fax: -+49 521 106 6445

DE (BIELEFELD) participant 417˙600.00
4    KATHOLIEKE UNIVERSITEIT LEUVEN

 Organization address address: Oude Markt 13
city: LEUVEN
postcode: 3000

contact info
Titolo: Ms.
Nome: Maria
Cognome: Vereeken
Email: send email
Telefono: -326488
Fax: -326499

BE (LEUVEN) participant 395˙000.00
5    TEKNOLOGIAN TUTKIMUSKESKUS VTT

 Organization address address: TEKNIIKANTIE 4 A
city: ESPOO
postcode: 02044 VTT

contact info
Titolo: Ms.
Nome: Seija
Cognome: Flinck
Email: send email
Telefono: +358 50 326 5275
Fax: +358 20 722 7071

FI (ESPOO) participant 395˙000.00
6    WAGENINGEN UNIVERSITY

 Organization address address: DROEVENDAALSESTEEG 4
city: WAGENINGEN
postcode: 6708 PB

contact info
Nome: Jos
Cognome: Teunissen
Email: send email
Telefono: +31 317 485313
Fax: +31 317 484132

NL (WAGENINGEN) participant 389˙080.00
7    THE UNIVERSITY OF WARWICK

 Organization address address: Kirby Corner Road - University House -
city: COVENTRY
postcode: CV4 8UW

contact info
Titolo: Prof.
Nome: Peter
Cognome: Hedges
Email: send email
Telefono: -48580
Fax: -99179

UK (COVENTRY) participant 389˙000.00
8 KOBENHAVNS UNIVERSITET DK participant 386˙400.00
9    RIJKSUNIVERSITEIT GRONINGEN

 Organization address address: Broerstraat 5
city: GRONINGEN
postcode: 9712CP

contact info
Titolo: Mr.
Nome: Jan
Cognome: Poutsma
Email: send email
Telefono: 31503634142
Fax: 31503634500

NL (GRONINGEN) participant 350˙000.00
10    UNIVERSITE CATHOLIQUE DE LOUVAIN

 Organization address address: Place De L'Universite 1
city: LOUVAIN LA NEUVE
postcode: 1348

contact info
Titolo: Prof.
Nome: Spyridon Nicolas
Cognome: Agathos
Email: send email
Telefono: -473622
Fax: -473040

BE (LOUVAIN LA NEUVE) participant 338˙400.00
11    SODERTORNS HOGSKOLA

 Organization address address: Alfred Nobel's Alle 7
city: HUDDINGE
postcode: SE-141 89

contact info
Titolo: Mr.
Nome: Fredrik
Cognome: Stralind
Email: send email
Telefono: 4686084876
Fax: 4684084402

SE (HUDDINGE) participant 334˙760.00
12    UNIVERSITA DEGLI STUDI DELL'INSUBRIA

 Organization address address: Via Ravasi 2
city: VARESE
postcode: 21100

contact info
Titolo: Dr.
Nome: Luca
Cognome: Azimonti
Email: send email
Telefono: +390332 219308
Fax: +390332 219309

IT (VARESE) participant 291˙000.00
13    JULIUS KUHN-INSTITUT BUNDESFORSCHUNGSINSTITUT FUR KULTURPFLANZEN

 Organization address address: ERWIN-BAUR-STRASSE 27
city: QUEDLINBURG
postcode: 6484

contact info
Titolo: Mr.
Nome: Knut
Cognome: Steffens
Email: send email
Telefono: 495313000000
Fax: 495313000000

DE (QUEDLINBURG) participant 250˙000.00
14    UNIVERZA V LJUBLJANI

 Organization address address: KONGRESNI TRG 12
city: LJUBLJANA
postcode: 1000

contact info
Titolo: Ms.
Nome: Milena
Cognome: Prosen
Email: send email
Telefono: +386 1 4231161
Fax: + 386 1 2565782

SI (LJUBLJANA) participant 201˙000.00
15    BioDetection Systems B.V.

 Organization address address: Science Park 406
city: Amsterdam
postcode: 1098 XH

contact info
Titolo: Ms.
Nome: Yvette
Cognome: Van Scheppingen
Email: send email
Telefono: -4350721
Fax: -4350728

NL (Amsterdam) participant 190˙000.00
16    UNIVERSIDAD NACIONAL DE LA PLATA

 Organization address address: CALLE 7 776
city: LA PLATA
postcode: 1900

contact info
Titolo: Prof.
Nome: Antonio
Cognome: Lagares
Email: send email
Telefono: +54-221-4250497 (ext. 31)
Fax: -4245129

AR (LA PLATA) participant 165˙000.00
17    INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

 Organization address address: Rue De L'Universite 147
city: PARIS CEDEX 07
postcode: 75338

contact info
Titolo: Ms.
Nome: Nathalie
Cognome: Dospital
Email: send email
Telefono: (33) 1 42 75 94 84
Fax: (33) 1 42 75 91 59

FR (PARIS CEDEX 07) participant 78˙471.00
18    Whitby Seafoods Ltd

 Organization address address: Fairfield Way
city: Whitby
postcode: YO22 4PU

contact info
Titolo: Mr.
Nome: Edward
Cognome: Whittle
Email: send email
Telefono: +44 1947 606101
Fax: +44 1947 820589

UK (Whitby) participant 70˙000.00

Mappa


 Word cloud

Esplora la "nuvola delle parole (Word Cloud) per avere un'idea di massima del progetto.

industrial    chitin    waste    aquatic    relevance    lignin    tools    enzymes    metagenomics    data    terrestrial    metaexplore    mobilome    degradation    compounds    successfully    soil    sustainability    pool    materials    gene    bioremediation    biotechnology    mobile    laboratories    enzymatic    resistant    habitats    anthropogenic    environmental    functions    screening    enzyme    energy    recalcitrant    natural    halogenated    contain    selected    molecules    genetic   

 Obiettivo del progetto (Objective)

'This proposal will (further) develop and apply metagenomics tools to access the enzymatic potential borne in the cryptic biota of selected natural habitats, in particular target soil-related and aquatic ones. In the light of the environmental relevance of chitins and lignins (as natural compounds recalcitrant to degradation) and halogenated aliphatic and aromatic compounds (anthropogenic recalcitrant compounds), the enzymatic activities that we will target are functions able to degrade these compounds. A database of gene functions will be established and maintained. Next to its great relevance to environmental biotechnology including bioremediation, a spin-off of the work will be the discovery of novel biocatalytic functions of industrial relevance. We will in particular address the catabolic potential that is encoded by the mobilome, the collective pool of mobile genetic elements in the microbiota. We will further apply high-throughput (454-based) sequencing to rapidly unravel the metabolic complement in this mobile gene pool. The project brings together a suite of 15 contractors across Europe, encompassing 21 laboratories spread over 11 copuntries and including 4 SMEs. Most of the partners are renowned laboratories which have vast experience in metagenomics of environmental samples, biotechnology, enzymology, bioinformatics, the mobilome, waste management and bioremediation and enzyme production.'

Introduzione (Teaser)

Certain natural and synthetic compounds are resistant to degradation by natural enzymes. Scientists have conducted comprehensive genetic screening of aquatic and terrestrial organisms to find and design the appropriate enzymes for the recalcitrant molecules.

Descrizione progetto (Article)

Bioremediation has been used successfully for oil spills, chlorinated solvents and pesticides, but many compounds are resistant to degradation (recalcitrant). Using genetic material from the EU-funded project 'Metagenomics for bioexploration - Tools and application' (http://www.rug.nl/research/metaexplore/ (METAEXPLORE)) has helped to develop a wide range of improved enzymes.

In particular, the researchers focused on the naturally recalcitrant molecules chitin and lignin. Anthropogenic-sourced materials include halogenated and organic compounds as well as xenobiotic compounds foreign to biological systems, herbicides for example.

Following pre-screening of a large number of terrestrial and aquatic habitats with specially developed tools, the team cloned and sequenced promising enzymes from selected environments. A total of nine metagenomic libraries were produced from selected environmental habitats. A software platform (MetaSAMS) with search routines, genomic mapping and tools for comparative analysis of metagenomics data has been successfully developed. All data warehouses contain functional genes and operons to provide genetic resources for future explorations.

Derived from industrial demand, these collections were screened for improved enzymes, including novel chitinases, laccases/ligninases, and aerobic and anaerobic dehalogenases. Another target was the beta-amino transferring enzyme family involved in the production of a wide range of pharmaceuticals.

A large proportion of the gene sequences coding for the enzymes are housed on the mobile genetic element of microbes, the mobilome. After characterisation of structure and function and expression in suitable hosts, the researchers extended their activities of the cream of the enzymes for use in industry using directed evolution.

METAEXPLORE deliverables are expected to have an important impact on sustainability and EU environmental goals. Alternative raw materials are needed for the future supply of energy and chemicals. Recalcitrant waste materials like lignin and chitin contain various building blocks for chemical production. Disposal of waste is expensive and creates numerous environmental and public health challenges.

Bioremediation not only helps keep nature clean in a natural way, it is also a low-energy process for decontamination of water and soil. Availability of novel biocatalysts is an important pillar of sustainability given the innumerable industrial reactions based on catalysis.

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RUDI (2008)

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Q-COLLECT (2013)

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