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TB-EPF SIGNED

Enhanced Place Finding (EPF) of TB transmission hotspots

Total Cost €

EC-Contrib. €

Partnership

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TB-EPF project word cloud

Explore the words cloud of the TB-EPF project. It provides you a very rough idea of what is the project "TB-EPF" about.

complemented phone unequally unbiased everyday ultimately aggregated tested interruptb transmission epidemiological mycobacterial ventilation identification infectious genetic intervention risk strategy mathematical analyze tool lowering contact burden programs events models app time household demonstrated hotspots suggests consequently diseases spatial epf map investigation active population fashion poc data erc national retrospectively bacterial complement health reconsent efficient 70 endemic gambia place outside movements network warns detect aerosols blocking public 2000 tb cheap isolates enhanced places person patients prospective investigations interventions hotspot outbreaks molecular initiated occurs tracking distributed collection seek sequenced transmitted requiring longer

Project "TB-EPF" data sheet

The following table provides information about the project.

Coordinator	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE Organization address address: Nationalestraat 155 city: ANTWERPEN postcode: 2000 website: www.itg.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Belgium [BE]
Total cost	149˙783 €
EC max contribution	149˙783 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE Organization address address: Nationalestraat 155 city: ANTWERPEN postcode: 2000 website: www.itg.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ANTWERPEN)	coordinator	69˙523.00
2	DALBERG DATA INSIGHTS DALBERG DATA INSIGHTS Organization address address: PLACE DU CHAMP DE MARS 5 city: BRUXELLES postcode: 1050 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (BRUXELLES)	participant	46˙277.00
3	UNITED KINGDOM RESEARCH AND INNOVATION UNITED KINGDOM RESEARCH AND INNOVATION Organization address address: POLARIS HOUSE NORTH STAR AVENUE city: SWINDON postcode: SN2 1FL website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	31˙661.00
4	UNIVERSITE CATHOLIQUE DE LOUVAIN UNIVERSITE CATHOLIQUE DE LOUVAIN Organization address address: PLACE DE L UNIVERSITE 1 city: LOUVAIN LA NEUVE postcode: 1348 website: www.uclouvain.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (LOUVAIN LA NEUVE)	participant	2˙321.00
5	MEDICAL RESEARCH COUNCIL MEDICAL RESEARCH COUNCIL Organization address address: NORTH STAR AVENUE POLARIS HOUSE 2 FLOOR DAVID PHILLIPS BUILDING city: SWINDON postcode: SN2 1FL website: www.mrc.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SWINDON)	participant	0.00

Map

Project objective

TB is transmitted via person-to-person aerosols. Recent studies suggests that in TB endemic areas up to 70% of transmission events take place outside the household in public places. Moreover, TB transmission is unequally spatially distributed and occurs in transmission hotspot areas. Mathematical models consequently demonstrated that identifying hotspots and blocking within-hotspot-transmission through targeted public health interventions will be the most efficient way of lowering the TB burden. In the present PoC proposal we aim to complement the population-based Enhanced-Case-Finding intervention tested in the INTERRUPTB study, with a spatially more targeted “Enhanced-Place-Finding” (EPF) approach to identify transmission hotspots in an unbiased fashion. Using traditional methods to find transmission hotspots can only be done retrospectively after years of data collection. Therefore we propose a novel EPF strategy to detect transmission hotspots in real-time using phone-tracking technology to establish a spatial map of aggregated TB patients movements. Within the ERC-funded INTERRUPTB study in The Gambia, we sequenced 2000 mycobacterial isolates, which allows us to establish a bacterial genetic transmission network. Within the PoC proposal, we seek to reconsent these patients to analyze their everyday movements using classical contact investigation complemented by phone tracking, to determine which public places have an increased risk of TB transmission. We aim to demonstrate that phone tracking of TB patients can be a cheap, easy, and, most importantly, prospective TB transmission hotspots identification tool, no longer requiring molecular epidemiological investigations. Such a finding can ultimately be developed into an app that warns national TB programs of early TB outbreaks, so that early public health measures like increased ventilation and active case finding can be initiated. This approach can furthermore be applied to other infectious diseases.

Publications

List of publications.
year	authors and title	journal	last update
2019	Bouke C. de Jong, Badou M. Gaye, Jeroen Luyten, Bart van Buitenen, Emmanuel AndrÃ©, Conor J. Meehan, Cian Oâ€™Siochain, Kristyna Tomsu, JÃ©rÃ´me Urbain, Koen Peeters Grietens, Maureen Njue, Wim Pinxten, Florian Gehre, Ousman Nyan, Anne BuvÃ©, Anna Roca, Raffaella Ravinetto, Martin Antonio Ethical Considerations for Movement Mapping to Identify Disease Transmission Hotspots published pages: , ISSN: 1080-6040, DOI: 10.3201/eid2507.181421	Emerging Infectious Diseases 25/7	2020-03-05

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