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TB-EPF SIGNED

Enhanced Place Finding (EPF) of TB transmission hotspots

Total Cost €

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EC-Contrib. €

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Partnership

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Project "TB-EPF" data sheet

The following table provides information about the project.

Coordinator
PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE 

Organization address
address: Nationalestraat 155
city: ANTWERPEN
postcode: 2000
website: www.itg.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 149˙783 €
 EC max contribution 149˙783 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    PRINS LEOPOLD INSTITUUT VOOR TROPISCHE GENEESKUNDE BE (ANTWERPEN) coordinator 69˙523.00
2    DALBERG DATA INSIGHTS BE (BRUXELLES) participant 46˙277.00
3    UNITED KINGDOM RESEARCH AND INNOVATION UK (SWINDON) participant 31˙661.00
4    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 2˙321.00
5    MEDICAL RESEARCH COUNCIL UK (SWINDON) participant 0.00

Map

 Project objective

TB is transmitted via person-to-person aerosols. Recent studies suggests that in TB endemic areas up to 70% of transmission events take place outside the household in public places. Moreover, TB transmission is unequally spatially distributed and occurs in transmission hotspot areas. Mathematical models consequently demonstrated that identifying hotspots and blocking within-hotspot-transmission through targeted public health interventions will be the most efficient way of lowering the TB burden. In the present PoC proposal we aim to complement the population-based Enhanced-Case-Finding intervention tested in the INTERRUPTB study, with a spatially more targeted “Enhanced-Place-Finding” (EPF) approach to identify transmission hotspots in an unbiased fashion. Using traditional methods to find transmission hotspots can only be done retrospectively after years of data collection. Therefore we propose a novel EPF strategy to detect transmission hotspots in real-time using phone-tracking technology to establish a spatial map of aggregated TB patients movements. Within the ERC-funded INTERRUPTB study in The Gambia, we sequenced 2000 mycobacterial isolates, which allows us to establish a bacterial genetic transmission network. Within the PoC proposal, we seek to reconsent these patients to analyze their everyday movements using classical contact investigation complemented by phone tracking, to determine which public places have an increased risk of TB transmission. We aim to demonstrate that phone tracking of TB patients can be a cheap, easy, and, most importantly, prospective TB transmission hotspots identification tool, no longer requiring molecular epidemiological investigations. Such a finding can ultimately be developed into an app that warns national TB programs of early TB outbreaks, so that early public health measures like increased ventilation and active case finding can be initiated. This approach can furthermore be applied to other infectious diseases.

 Publications

year authors and title journal last update
List of publications.
2019 Bouke C. de Jong, Badou M. Gaye, Jeroen Luyten, Bart van Buitenen, Emmanuel André, Conor J. Meehan, Cian O’Siochain, Kristyna Tomsu, Jérôme Urbain, Koen Peeters Grietens, Maureen Njue, Wim Pinxten, Florian Gehre, Ousman Nyan, Anne Buvé, Anna Roca, Raffaella Ravinetto, Martin Antonio
Ethical Considerations for Movement Mapping to Identify Disease Transmission Hotspots
published pages: , ISSN: 1080-6040, DOI: 10.3201/eid2507.181421
Emerging Infectious Diseases 25/7 2020-03-05

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