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CuHypMECH SIGNED

New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle

Total Cost €

0

EC-Contrib. €

0

Partnership

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 CuHypMECH project word cloud

Explore the words cloud of the CuHypMECH project. It provides you a very rough idea of what is the project "CuHypMECH" about.

selective    18f    assimilates    reports    oncology    diagnose    discovery    body    ratio    incorporated    hypoxia    glucose    metabolic    encountered    consumption    selectively    mechanism    microenvironment    binding    unmet    radiotracer    owing    multidisciplinary    nuclear    radio    tumour    stable    pet    signal    efforts    cycle    environment    spect    therapy    isotopes    proliferation    metabolism    cellular    stability    transfer    background    selectivity    quality    mapping    specificity    nutritional    proteins    functional    drives    copper    bio    form    chemistry    vivo    complexes    disease    hot    tumours    labelled    systematic    64cu    until    approved    biophysical    metal    fdg    clinical    routinely    despite    biology    ed    sites    clinically    cardiology    ct    structural    cold    resistance    radiotracers    limits    neurology    consume    oxidising    biomarker    visualisation    tracers    proprietary    controversial    tracer    marker    emphasising    angiogenesis    malignant    imaging    medicine    examined   

Project "CuHypMECH" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙499˙345 €
 EC max contribution 1˙499˙345 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 1˙499˙345.00

Map

 Project objective

Imaging of hypoxia is important in many disease states in oncology, cardiology, and neurology. Hypoxia is a common condition encountered within the tumour microenvironment that drives proliferation, angiogenesis, and resistance to therapy. Despite on-going efforts to identify hypoxia, until now there is no clinically approved imaging biomarker, due to both low tumour uptake, and a low signal to background (S/B) ratio that affects the imaging quality. Nuclear Medicine is using labelled radio-isotopes for PET/CT and SPECT imaging. These radio-tracers diagnose the metabolic processes in the body. Among these tracers, 18F-FDG is the most routinely used as a marker of glucose metabolism. However, not all tumours consume glucose, and glucose consumption is not specific only for malignant tumours, which limits its application. Copper is a nutritional metal, recently examined as a radiotracer for hypoxia, owing to its to the oxidising environment. Clinical and in-vivo studies on various 64Cu(II)-PET radiotracers resulted in controversial reports on the specificity of the current tracers for hypoxia imaging due to non-selective bio-distribution & low S/B ratio. This multidisciplinary proposal focuses on the discovery of comprehensive signal pathways of the cellular copper cycle using advanced biophysical methods and a proprietary design of 64Cu(II) radiotracer. This radiotracer will be incorporated in the cellular copper cycle, and will enable to selectively target the oxidising environment in tumours. The design of the new radiotracer is based on systematic structural & functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. This new copper tracer should increase the selectivity of tumour uptake, stability, and improve bio-distribution. This project assimilates cold and hot chemistry and biology, while emphasising the clinical unmet need in metal based radiotracer that form stable complexes.

 Publications

year authors and title journal last update
List of publications.
2019 Zena Qasem, Matic Pavlin, Ida Ritacco, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
The pivotal role of MBD4–ATP7B in the human Cu( i ) excretion path as revealed by EPR experiments and all-atom simulations
published pages: 1288-1297, ISSN: 1756-5901, DOI: 10.1039/C9MT00067D
Metallomics 11/7 2020-04-24
2019 Pavlin, Qasem, Sameach, Gevorkyan-Airapetov, Ritacco, Ruthstein, Magistrato
Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins
published pages: 3462, ISSN: 1422-0067, DOI: 10.3390/ijms20143462
International Journal of Molecular Sciences 20/14 2020-04-24
2019 Alessandra Magistrato, Matic Pavlin, Zena Qasem, Sharon Ruthstein
Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts
published pages: 26-33, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2019.05.002
Current Opinion in Structural Biology 58 2020-04-24
2018 Ruthstein, Sharon; Shenberger, Yulia
COPPER-CONTAINING COMPLEX AND USES THEREOF
published pages: , ISSN: , DOI: 10.5281/zenodo.3244872
PCT-IL 2 2020-04-24
2018 Yulia Shenberger, Ortal Marciano, Hugo E. Gottlieb, Sharon Ruthstein
Insights into the N-terminal Cu(II) and Cu(I) binding sites of the human copper transporter CTR1
published pages: 1985-2002, ISSN: 0095-8972, DOI: 10.1080/00958972.2018.1492717
Journal of Coordination Chemistry 71/11-13 2019-05-22

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