CuHypMECH SIGNED
New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle
Total Cost €
0EC-Contrib. €
0Partnership
0Views
0CuHypMECH project word cloud
Explore the words cloud of the CuHypMECH project. It provides you a very rough idea of what is the project "CuHypMECH" about.
Project "CuHypMECH" data sheet
The following table provides information about the project.
| Coordinator |
BAR ILAN UNIVERSITY
Organization address contact info |
| Coordinator Country | Israel [IL] |
| Total cost | 1˙499˙345 € |
| EC max contribution | 1˙499˙345 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2017-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-09-01 to 2022-08-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | BAR ILAN UNIVERSITY | IL (RAMAT GAN) | coordinator | 1˙499˙345.00 |
Map
Project objective
Imaging of hypoxia is important in many disease states in oncology, cardiology, and neurology. Hypoxia is a common condition encountered within the tumour microenvironment that drives proliferation, angiogenesis, and resistance to therapy. Despite on-going efforts to identify hypoxia, until now there is no clinically approved imaging biomarker, due to both low tumour uptake, and a low signal to background (S/B) ratio that affects the imaging quality. Nuclear Medicine is using labelled radio-isotopes for PET/CT and SPECT imaging. These radio-tracers diagnose the metabolic processes in the body. Among these tracers, 18F-FDG is the most routinely used as a marker of glucose metabolism. However, not all tumours consume glucose, and glucose consumption is not specific only for malignant tumours, which limits its application. Copper is a nutritional metal, recently examined as a radiotracer for hypoxia, owing to its to the oxidising environment. Clinical and in-vivo studies on various 64Cu(II)-PET radiotracers resulted in controversial reports on the specificity of the current tracers for hypoxia imaging due to non-selective bio-distribution & low S/B ratio. This multidisciplinary proposal focuses on the discovery of comprehensive signal pathways of the cellular copper cycle using advanced biophysical methods and a proprietary design of 64Cu(II) radiotracer. This radiotracer will be incorporated in the cellular copper cycle, and will enable to selectively target the oxidising environment in tumours. The design of the new radiotracer is based on systematic structural & functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. This new copper tracer should increase the selectivity of tumour uptake, stability, and improve bio-distribution. This project assimilates cold and hot chemistry and biology, while emphasising the clinical unmet need in metal based radiotracer that form stable complexes.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
Zena Qasem, Matic Pavlin, Ida Ritacco, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein The pivotal role of MBD4–ATP7B in the human Cu( i ) excretion path as revealed by EPR experiments and all-atom simulations published pages: 1288-1297, ISSN: 1756-5901, DOI: 10.1039/C9MT00067D |
Metallomics 11/7 | 2020-04-24 |
| 2019 |
Pavlin, Qasem, Sameach, Gevorkyan-Airapetov, Ritacco, Ruthstein, Magistrato Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins published pages: 3462, ISSN: 1422-0067, DOI: 10.3390/ijms20143462 |
International Journal of Molecular Sciences 20/14 | 2020-04-24 |
| 2019 |
Alessandra Magistrato, Matic Pavlin, Zena Qasem, Sharon Ruthstein Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts published pages: 26-33, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2019.05.002 |
Current Opinion in Structural Biology 58 | 2020-04-24 |
| 2018 |
Ruthstein, Sharon; Shenberger, Yulia COPPER-CONTAINING COMPLEX AND USES THEREOF published pages: , ISSN: , DOI: 10.5281/zenodo.3244872 |
PCT-IL 2 | 2020-04-24 |
| 2018 |
Yulia Shenberger, Ortal Marciano, Hugo E. Gottlieb, Sharon Ruthstein Insights into the N-terminal Cu(II) and Cu(I) binding sites of the human copper transporter CTR1 published pages: 1985-2002, ISSN: 0095-8972, DOI: 10.1080/00958972.2018.1492717 |
Journal of Coordination Chemistry 71/11-13 | 2019-05-22 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CUHYPMECH" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "CUHYPMECH" are provided by the European Opendata Portal: CORDIS opendata.