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CuHypMECH SIGNED

New Nuclear Medicine Imaging Radiotracer 64Cu(II) for diagnosing Hypoxia Conditions Based on the Cellular Copper Cycle

Total Cost €

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EC-Contrib. €

0

Partnership

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 CuHypMECH project word cloud

Explore the words cloud of the CuHypMECH project. It provides you a very rough idea of what is the project "CuHypMECH" about.

oxidising    controversial    proteins    angiogenesis    cellular    tracer    medicine    limits    hot    vivo    18f    sites    proprietary    quality    tumours    visualisation    specificity    approved    radio    systematic    ed    oncology    emphasising    metabolic    cold    64cu    nuclear    therapy    neurology    resistance    radiotracer    glucose    multidisciplinary    functional    labelled    stability    drives    form    owing    structural    marker    biomarker    selectivity    biology    isotopes    selectively    metabolism    unmet    cardiology    copper    selective    efforts    incorporated    tumour    tracers    reports    encountered    pet    body    mechanism    biophysical    radiotracers    background    examined    binding    discovery    clinically    fdg    bio    chemistry    nutritional    diagnose    despite    clinical    proliferation    cycle    ct    disease    ratio    metal    environment    imaging    microenvironment    transfer    consume    signal    malignant    spect    routinely    hypoxia    consumption    assimilates    mapping    until    complexes    stable   

Project "CuHypMECH" data sheet

The following table provides information about the project.

Coordinator
BAR ILAN UNIVERSITY 

Organization address
address: BAR ILAN UNIVERSITY CAMPUS
city: RAMAT GAN
postcode: 52900
website: www.biu.ac.il

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Israel [IL]
 Total cost 1˙499˙345 €
 EC max contribution 1˙499˙345 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2022-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    BAR ILAN UNIVERSITY IL (RAMAT GAN) coordinator 1˙499˙345.00

Map

 Project objective

Imaging of hypoxia is important in many disease states in oncology, cardiology, and neurology. Hypoxia is a common condition encountered within the tumour microenvironment that drives proliferation, angiogenesis, and resistance to therapy. Despite on-going efforts to identify hypoxia, until now there is no clinically approved imaging biomarker, due to both low tumour uptake, and a low signal to background (S/B) ratio that affects the imaging quality. Nuclear Medicine is using labelled radio-isotopes for PET/CT and SPECT imaging. These radio-tracers diagnose the metabolic processes in the body. Among these tracers, 18F-FDG is the most routinely used as a marker of glucose metabolism. However, not all tumours consume glucose, and glucose consumption is not specific only for malignant tumours, which limits its application. Copper is a nutritional metal, recently examined as a radiotracer for hypoxia, owing to its to the oxidising environment. Clinical and in-vivo studies on various 64Cu(II)-PET radiotracers resulted in controversial reports on the specificity of the current tracers for hypoxia imaging due to non-selective bio-distribution & low S/B ratio. This multidisciplinary proposal focuses on the discovery of comprehensive signal pathways of the cellular copper cycle using advanced biophysical methods and a proprietary design of 64Cu(II) radiotracer. This radiotracer will be incorporated in the cellular copper cycle, and will enable to selectively target the oxidising environment in tumours. The design of the new radiotracer is based on systematic structural & functional mapping of the copper binding sites to the various copper proteins and the visualisation of the transfer mechanism. This new copper tracer should increase the selectivity of tumour uptake, stability, and improve bio-distribution. This project assimilates cold and hot chemistry and biology, while emphasising the clinical unmet need in metal based radiotracer that form stable complexes.

 Publications

year authors and title journal last update
List of publications.
2019 Zena Qasem, Matic Pavlin, Ida Ritacco, Lada Gevorkyan-Airapetov, Alessandra Magistrato, Sharon Ruthstein
The pivotal role of MBD4–ATP7B in the human Cu( i ) excretion path as revealed by EPR experiments and all-atom simulations
published pages: 1288-1297, ISSN: 1756-5901, DOI: 10.1039/C9MT00067D
Metallomics 11/7 2020-04-24
2019 Pavlin, Qasem, Sameach, Gevorkyan-Airapetov, Ritacco, Ruthstein, Magistrato
Unraveling the Impact of Cysteine-to-Serine Mutations on the Structural and Functional Properties of Cu(I)-Binding Proteins
published pages: 3462, ISSN: 1422-0067, DOI: 10.3390/ijms20143462
International Journal of Molecular Sciences 20/14 2020-04-24
2019 Alessandra Magistrato, Matic Pavlin, Zena Qasem, Sharon Ruthstein
Copper trafficking in eukaryotic systems: current knowledge from experimental and computational efforts
published pages: 26-33, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2019.05.002
Current Opinion in Structural Biology 58 2020-04-24
2018 Ruthstein, Sharon; Shenberger, Yulia
COPPER-CONTAINING COMPLEX AND USES THEREOF
published pages: , ISSN: , DOI: 10.5281/zenodo.3244872
PCT-IL 2 2020-04-24
2018 Yulia Shenberger, Ortal Marciano, Hugo E. Gottlieb, Sharon Ruthstein
Insights into the N-terminal Cu(II) and Cu(I) binding sites of the human copper transporter CTR1
published pages: 1985-2002, ISSN: 0095-8972, DOI: 10.1080/00958972.2018.1492717
Journal of Coordination Chemistry 71/11-13 2019-05-22

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The information about "CUHYPMECH" are provided by the European Opendata Portal: CORDIS opendata.

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