Explore the words cloud of the CHROMATADS project. It provides you a very rough idea of what is the project "CHROMATADS" about.
The following table provides information about the project.
EBERHARD KARLS UNIVERSITAET TUEBINGEN
|Coordinator Country||Germany [DE]|
|Total cost||1˙498˙216 €|
|EC max contribution||1˙498˙216 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-01-01 to 2022-12-31|
Take a look of project's partnership.
|1||EBERHARD KARLS UNIVERSITAET TUEBINGEN||DE (TUEBINGEN)||coordinator||1˙498˙216.00|
The three-dimensional organization of the genome, which strikingly correlates with gene activity, is critical for many cellular processes. The evolution of molecular techniques has allowed us to unveil chromatin structure at an unprecedented resolution. The most intriguing chromatin structures observed in animals are TADs (Topologically Associating Domains), which represent the functional and structural chromatin domains demarcating the genome. Structural proteins such as insulators proteins, on the other hand, have been shown to play crucial roles in mediating the formation of TADs. However, major structural factors relevant to chromatin structure are still waiting to be discovered in land plants. My preliminary work shows that TADs are widely distributed across the rice genome, and motif sequence analysis suggests the enrichment of plant-specific transcription factors at TAD boundaries, which jointly give rise to an exciting hypothesis that these proteins might be the long-sought-after insulators in land plants. By using various state-of-the-art molecular and computational tools, this timely project aims to fill a huge gap in plant functional genomics and substantially advance our understanding of three-dimensional chromatin structure. This project consists four major aims, which collectively will uncover the identities of plant insulator proteins and generate insights into the dynamics of structural chromatin domains during stress adaptation. Aim 1 will identify and characterize the stability and plasticity of functional chromatin domains in the rice genome during temperature stress adaptation. Aim 2 will identify insulator elements and other structural features of chromatin packing in the Marchantia polymorpha genome from a structural genomics approach. Aim 3 will establish the role of candidate proteins as plant insulators. Lastly, Aim 4 will generate functional insights into the molecular mechanism by which plant insulators shape the three-dimensional genome.
|year||authors and title||journal||last update|
Nan Wang, Chang Liu
Implications of liquidâ€“liquid phase separation in plant chromatin organization and transcriptional control
published pages: 59-65, ISSN: 0959-437X, DOI: 10.1016/j.gde.2019.06.003
|Current Opinion in Genetics & Development 55||2019-08-29|
Ezgi SÃ¼heyla DoÄŸan, Chang Liu
Three-dimensional chromatin packing and positioning of plant genomes
published pages: 521-529, ISSN: 2055-0278, DOI: 10.1038/s41477-018-0199-5
|Nature Plants 4/8||2019-09-04|
Bo Hu, Nan Wang, Xiuli Bi, Ezgi SÃ¼heyla Karaaslan, Anna-Lena Weber, Wangsheng Zhu, Kenneth Wayne Berendzen, Chang Liu
Plant lamin-like proteins mediate chromatin tethering at the nuclear periphery
published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-019-1694-3
|Genome Biology 20/1||2019-09-04|
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CHROMATADS" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (email@example.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "CHROMATADS" are provided by the European Opendata Portal: CORDIS opendata.
Comprehensive anatomical, genetic and functional identification of cerebellar nuclei neurons and their roles in sensorimotor tasksRead More
Equidistribution, fractal measures and arithmeticRead More
Vaccine development against variable pathogensRead More