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A4B SIGNED

Analytics for Biologics

Total Cost €

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EC-Contrib. €

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Partnership

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Project "A4B" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF 

Organization address
address: Martinistrasse 52
city: HAMBURG
postcode: 20251
website: www.uke.uni-hamburg.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.analytics4biologics.eu/
 Total cost 3˙933˙617 €
 EC max contribution 3˙933˙617 € (100%)
 Programme 1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
 Code Call H2020-MSCA-ITN-2017
 Funding Scheme MSCA-ITN-ETN
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2021-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF DE (HAMBURG) coordinator 498˙432.00
2    UNIVERSITAET FUER BODENKULTUR WIEN AT (WIEN) participant 511˙868.00
3    ACADEMISCH ZIEKENHUIS LEIDEN NL (LEIDEN) participant 510˙748.00
4    RIJKSUNIVERSITEIT GRONINGEN NL (GRONINGEN) participant 510˙748.00
5    ALPHALYSE A/S DK (ODENSE) participant 290˙081.00
6    SYDDANSK UNIVERSITET DK (ODENSE M) participant 290˙081.00
7    UNIVERSITETET I OSLO NO (OSLO) participant 286˙275.00
8    LUDGER LIMITED UK (ABINGDON) participant 273˙287.00
9    KUNGLIGA TEKNISKA HOEGSKOLAN SE (STOCKHOLM) participant 263˙659.00
10    EBERHARD KARLS UNIVERSITAET TUEBINGEN DE (TUEBINGEN) participant 249˙216.00
11    HEXAL AKTIENGESELLSCHAFT DE (HOLZKIRCHEN) participant 249˙216.00

Map

 Project objective

Qualitative and quantitative analysis and purification of therapeutic protein species (TP-S) – coded by the same gene, thus chemically often very similar – is one of the most challenging problems in analytical chemistry today. This problem is of huge impact in the area of therapeutic proteins (TPs) – a rapidly growing market – causing a high demand in specialists in the field of TP manufacturing. This demand can currently not be met by single European universities. In an Europe-wide joint research and training network the graduate school A4B will offer a specific training program yielding the required specialists. A4B-PhD students will develop solutions for the most urgent problems in TP production and analysis. Production of TPs is associated with the generation of poorly effective or even harmful species. For an effective removal of these species, A4B-students will develop improved purification methods based on advanced affinity and displacement chromatography. For controlling effectiveness and design of experiments, fast and reliable qualitative and quantitative detection methods are required. The development of these analytical methods will focus on the chemical composition of TP-S including their glycans and other posttranslational modifications (PTMs). We will use high-end electrophoretic, liquid chromatographic, and mass spectrometry approaches in combination with bioinformatics. The developed methods will be tested and used for improving protein production processes and therapy control. All A4B students will receive a basic education in manufacturing and marketing of TPS. Through their research projects the students will develop in depth expertise in one of the areas covered by the consortium. This project will thus generate urgently needed new methods for an improved analysis and purification of TP-S, while at the same time ensuring that well qualified young researchers are available for this rapidly growing area of the pharmaceutical industry.

 Deliverables

List of deliverables.
Publication of advertising for open ESR positions Other 2020-03-24 10:44:12
Project Website Websites, patent fillings, videos etc. 2020-03-24 10:44:13

Take a look to the deliverables list in detail:  detailed list of A4B deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Ramin Fazel, Yudong Guan, Behrouz Vaziri, Christoph Krisp, Laura Heikaus, Amirhossein Saadati, Siti Nurul Hidayah, Manasi Gaikwad, Hartmut Schlüter
Structural and In Vitro Functional Comparability Analysis of Altebrel™, a Proposed Etanercept Biosimilar: Focus on Primary Sequence and Glycosylation
published pages: 14, ISSN: 1424-8247, DOI: 10.3390/ph12010014
Pharmaceuticals 12/1 2020-03-24
2020 Siti Nurul Hidayah, Manasi Gaikwad, Laura Heikaus, Hartmut Schlüter
Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry
published pages: , ISSN: , DOI: 10.5772/intechopen.89644
Proteoforms [Working Title] 2020-03-24
2019 Peter Bults, Baubek Spanov, Oladapo Olaleye, Nico C. van de Merbel, Rainer Bischoff
Intact protein bioanalysis by liquid chromatography – High-resolution mass spectrometry
published pages: 155-167, ISSN: 1570-0232, DOI: 10.1016/j.jchromb.2019.01.032
Journal of Chromatography B 1110-1111 2020-03-24
2019 Kyowon Jeong, Jihyung Kim, Manasi Gaikwad, Siti Nurul Hidayah, Laura Heikaus, Hartmut Schlüter, Oliver Kohlbacher
FLASHDeconv: Ultrafast, high-quality feature deconvolution for top-down proteomics
published pages: , ISSN: , DOI: 10.1101/714915
2020-03-24
2019 Steffen Lippold, Simone Nicolardi, Manfred Wuhrer, David Falck
Proteoform-Resolved FcɤRIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties
published pages: 1-10, ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00698
Frontiers in Chemistry 7 2020-03-24
2019 Christian J. Koehler, Bernd Thiede
Predominant cleavage of proteins N-terminal to serines and threonines using scandium(III) triflate
published pages: , ISSN: 0949-8257, DOI: 10.1007/s00775-019-01733-7
JBIC Journal of Biological Inorganic Chemistry 2020-03-24

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The information about "A4B" are provided by the European Opendata Portal: CORDIS opendata.

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