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A4B SIGNED

Analytics for Biologics

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

A4B project word cloud

Explore the words cloud of the A4B project. It provides you a very rough idea of what is the project "A4B" about.

joint generate demand composition universities analytical detection ptms met phd causing specialists industry yielding receive protein harmful displacement qualified network pharmaceutical bioinformatics a4b graduate students purification proteins glycans education posttranslational coded area tps manufacturing electrophoretic solutions market generation gene school single covered qualitative mass therapy species spectrometry therapeutic quantitative affinity liquid huge chemical chemically fast chemistry urgently urgent poorly effectiveness time tp expertise experiments removal tested marketing combination young basic chromatography modifications chromatographic training

Project "A4B" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Organization address address: Martinistrasse 52 city: HAMBURG postcode: 20251 website: www.uke.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.analytics4biologics.eu/
Total cost	3˙933˙617 €
EC max contribution	3˙933˙617 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2017
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-10-01 to 2021-09-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF Organization address address: Martinistrasse 52 city: HAMBURG postcode: 20251 website: www.uke.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	coordinator	498˙432.00
2	UNIVERSITAET FUER BODENKULTUR WIEN UNIVERSITAET FUER BODENKULTUR WIEN Organization address address: GREGOR MENDEL STRASSE 33 city: WIEN postcode: 1180 website: www.boku.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	511˙868.00
3	ACADEMISCH ZIEKENHUIS LEIDEN ACADEMISCH ZIEKENHUIS LEIDEN Organization address address: ALBINUSDREEF 2 city: LEIDEN postcode: 2333 ZA website: www.lumc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (LEIDEN)	participant	510˙748.00
4	RIJKSUNIVERSITEIT GRONINGEN RIJKSUNIVERSITEIT GRONINGEN Organization address address: Broerstraat 5 city: GRONINGEN postcode: 9712CP website: www.rug.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (GRONINGEN)	participant	510˙748.00
5	ALPHALYSE A/S ALPHALYSE A/S Organization address address: UNSBJERGVEJ 4 city: ODENSE postcode: 5220 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE)	participant	290˙081.00
6	SYDDANSK UNIVERSITET SYDDANSK UNIVERSITET Organization address address: CAMPUSVEJ 55 city: ODENSE M postcode: 5230 website: www.sdu.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (ODENSE M)	participant	290˙081.00
7	UNIVERSITETET I OSLO UNIVERSITETET I OSLO Organization address address: PROBLEMVEIEN 5-7 city: OSLO postcode: 313 website: www.uio.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (OSLO)	participant	286˙275.00
8	LUDGER LIMITED LUDGER LIMITED Organization address address: CULHAM SCIENCE CENTRE - BUILDING E1 city: ABINGDON postcode: OX14 3EB website: www.ludger.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (ABINGDON)	participant	273˙287.00
9	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	263˙659.00
10	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	249˙216.00
11	HEXAL AKTIENGESELLSCHAFT HEXAL AKTIENGESELLSCHAFT Organization address address: INDUSTRIESTR. 25 city: HOLZKIRCHEN postcode: 83607 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HOLZKIRCHEN)	participant	249˙216.00

Map

Project objective

Qualitative and quantitative analysis and purification of therapeutic protein species (TP-S) – coded by the same gene, thus chemically often very similar – is one of the most challenging problems in analytical chemistry today. This problem is of huge impact in the area of therapeutic proteins (TPs) – a rapidly growing market – causing a high demand in specialists in the field of TP manufacturing. This demand can currently not be met by single European universities. In an Europe-wide joint research and training network the graduate school A4B will offer a specific training program yielding the required specialists. A4B-PhD students will develop solutions for the most urgent problems in TP production and analysis. Production of TPs is associated with the generation of poorly effective or even harmful species. For an effective removal of these species, A4B-students will develop improved purification methods based on advanced affinity and displacement chromatography. For controlling effectiveness and design of experiments, fast and reliable qualitative and quantitative detection methods are required. The development of these analytical methods will focus on the chemical composition of TP-S including their glycans and other posttranslational modifications (PTMs). We will use high-end electrophoretic, liquid chromatographic, and mass spectrometry approaches in combination with bioinformatics. The developed methods will be tested and used for improving protein production processes and therapy control. All A4B students will receive a basic education in manufacturing and marketing of TPS. Through their research projects the students will develop in depth expertise in one of the areas covered by the consortium. This project will thus generate urgently needed new methods for an improved analysis and purification of TP-S, while at the same time ensuring that well qualified young researchers are available for this rapidly growing area of the pharmaceutical industry.

Deliverables

List of deliverables.
Publication of advertising for open ESR positions	Other	2020-03-24 10:44:12
Project Website	Websites, patent fillings, videos etc.	2020-03-24 10:44:13

Take a look to the deliverables list in detail: detailed list of A4B deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2019	Ramin Fazel, Yudong Guan, Behrouz Vaziri, Christoph Krisp, Laura Heikaus, Amirhossein Saadati, Siti Nurul Hidayah, Manasi Gaikwad, Hartmut SchlÃ¼ter Structural and In Vitro Functional Comparability Analysis of Altebrelâ„¢, a Proposed Etanercept Biosimilar: Focus on Primary Sequence and Glycosylation published pages: 14, ISSN: 1424-8247, DOI: 10.3390/ph12010014	Pharmaceuticals 12/1	2020-03-24
2020	Siti Nurul Hidayah, Manasi Gaikwad, Laura Heikaus, Hartmut SchlÃ¼ter Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry published pages: , ISSN: , DOI: 10.5772/intechopen.89644	Proteoforms [Working Title]	2020-03-24
2019	Peter Bults, Baubek Spanov, Oladapo Olaleye, Nico C. van de Merbel, Rainer Bischoff Intact protein bioanalysis by liquid chromatography â€“ High-resolution mass spectrometry published pages: 155-167, ISSN: 1570-0232, DOI: 10.1016/j.jchromb.2019.01.032	Journal of Chromatography B 1110-1111	2020-03-24
2019	Kyowon Jeong, Jihyung Kim, Manasi Gaikwad, Siti Nurul Hidayah, Laura Heikaus, Hartmut SchlÃ¼ter, Oliver Kohlbacher FLASHDeconv: Ultrafast, high-quality feature deconvolution for top-down proteomics published pages: , ISSN: , DOI: 10.1101/714915		2020-03-24
2019	Steffen Lippold, Simone Nicolardi, Manfred Wuhrer, David Falck Proteoform-Resolved FcÉ¤RIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties published pages: 1-10, ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00698	Frontiers in Chemistry 7	2020-03-24
2019	Christian J. Koehler, Bernd Thiede Predominant cleavage of proteins N-terminal to serines and threonines using scandium(III) triflate published pages: , ISSN: 0949-8257, DOI: 10.1007/s00775-019-01733-7	JBIC Journal of Biological Inorganic Chemistry	2020-03-24

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The information about "A4B" are provided by the European Opendata Portal: CORDIS opendata.