Explore the words cloud of the A4B project. It provides you a very rough idea of what is the project "A4B" about.
The following table provides information about the project.
|Coordinator Country||Germany [DE]|
|Total cost||3˙933˙617 €|
|EC max contribution||3˙933˙617 € (100%)|
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
|Duration (year-month-day)||from 2017-10-01 to 2021-09-30|
Take a look of project's partnership.
|1||UNIVERSITAETSKLINIKUM HAMBURG-EPPENDORF||DE (HAMBURG)||coordinator||498˙432.00|
|2||UNIVERSITAET FUER BODENKULTUR WIEN||AT (WIEN)||participant||511˙868.00|
|3||ACADEMISCH ZIEKENHUIS LEIDEN||NL (LEIDEN)||participant||510˙748.00|
|4||RIJKSUNIVERSITEIT GRONINGEN||NL (GRONINGEN)||participant||510˙748.00|
|5||ALPHALYSE A/S||DK (ODENSE)||participant||290˙081.00|
|6||SYDDANSK UNIVERSITET||DK (ODENSE M)||participant||290˙081.00|
|7||UNIVERSITETET I OSLO||NO (OSLO)||participant||286˙275.00|
|8||LUDGER LIMITED||UK (ABINGDON)||participant||273˙287.00|
|9||KUNGLIGA TEKNISKA HOEGSKOLAN||SE (STOCKHOLM)||participant||263˙659.00|
|10||EBERHARD KARLS UNIVERSITAET TUEBINGEN||DE (TUEBINGEN)||participant||249˙216.00|
|11||HEXAL AKTIENGESELLSCHAFT||DE (HOLZKIRCHEN)||participant||249˙216.00|
Qualitative and quantitative analysis and purification of therapeutic protein species (TP-S) – coded by the same gene, thus chemically often very similar – is one of the most challenging problems in analytical chemistry today. This problem is of huge impact in the area of therapeutic proteins (TPs) – a rapidly growing market – causing a high demand in specialists in the field of TP manufacturing. This demand can currently not be met by single European universities. In an Europe-wide joint research and training network the graduate school A4B will offer a specific training program yielding the required specialists. A4B-PhD students will develop solutions for the most urgent problems in TP production and analysis. Production of TPs is associated with the generation of poorly effective or even harmful species. For an effective removal of these species, A4B-students will develop improved purification methods based on advanced affinity and displacement chromatography. For controlling effectiveness and design of experiments, fast and reliable qualitative and quantitative detection methods are required. The development of these analytical methods will focus on the chemical composition of TP-S including their glycans and other posttranslational modifications (PTMs). We will use high-end electrophoretic, liquid chromatographic, and mass spectrometry approaches in combination with bioinformatics. The developed methods will be tested and used for improving protein production processes and therapy control. All A4B students will receive a basic education in manufacturing and marketing of TPS. Through their research projects the students will develop in depth expertise in one of the areas covered by the consortium. This project will thus generate urgently needed new methods for an improved analysis and purification of TP-S, while at the same time ensuring that well qualified young researchers are available for this rapidly growing area of the pharmaceutical industry.
|Publication of advertising for open ESR positions||Other||2020-03-24 10:44:12|
|Project Website||Websites, patent fillings, videos etc.||2020-03-24 10:44:13|
Take a look to the deliverables list in detail: detailed list of A4B deliverables.
|year||authors and title||journal||last update|
Ramin Fazel, Yudong Guan, Behrouz Vaziri, Christoph Krisp, Laura Heikaus, Amirhossein Saadati, Siti Nurul Hidayah, Manasi Gaikwad, Hartmut SchlÃ¼ter
Structural and In Vitro Functional Comparability Analysis of Altebrelâ„¢, a Proposed Etanercept Biosimilar: Focus on Primary Sequence and Glycosylation
published pages: 14, ISSN: 1424-8247, DOI: 10.3390/ph12010014
Siti Nurul Hidayah, Manasi Gaikwad, Laura Heikaus, Hartmut SchlÃ¼ter
Preparing Proteoforms of Therapeutic Proteins for Top-Down Mass Spectrometry
published pages: , ISSN: , DOI: 10.5772/intechopen.89644
|Proteoforms [Working Title]||2020-03-24|
Peter Bults, Baubek Spanov, Oladapo Olaleye, Nico C. van de Merbel, Rainer Bischoff
Intact protein bioanalysis by liquid chromatography â€“ High-resolution mass spectrometry
published pages: 155-167, ISSN: 1570-0232, DOI: 10.1016/j.jchromb.2019.01.032
|Journal of Chromatography B 1110-1111||2020-03-24|
Kyowon Jeong, Jihyung Kim, Manasi Gaikwad, Siti Nurul Hidayah, Laura Heikaus, Hartmut SchlÃ¼ter, Oliver Kohlbacher
FLASHDeconv: Ultrafast, high-quality feature deconvolution for top-down proteomics
published pages: , ISSN: , DOI: 10.1101/714915
Steffen Lippold, Simone Nicolardi, Manfred Wuhrer, David Falck
Proteoform-Resolved FcÉ¤RIIIa Binding Assay for Fab Glycosylated Monoclonal Antibodies Achieved by Affinity Chromatography Mass Spectrometry of Fc Moieties
published pages: 1-10, ISSN: 2296-2646, DOI: 10.3389/fchem.2019.00698
|Frontiers in Chemistry 7||2020-03-24|
Christian J. Koehler, Bernd Thiede
Predominant cleavage of proteins N-terminal to serines and threonines using scandium(III) triflate
published pages: , ISSN: 0949-8257, DOI: 10.1007/s00775-019-01733-7
|JBIC Journal of Biological Inorganic Chemistry||2020-03-24|
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