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ArthroDUR SIGNED

Bifunctional and regeneratively active biomaterial: Towards an ultimate solution for osteoarthritis treatment

Total Cost €

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EC-Contrib. €

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Partnership

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 ArthroDUR project word cloud

Explore the words cloud of the ArthroDUR project. It provides you a very rough idea of what is the project "ArthroDUR" about.

inflammation    therapy    solution    time    extracellular    cure    disorder    accumulation    arthritis    ameliorate    caused    tissue    skeletal    million    joint    material    blood    augmented    firstly    strategy    synthesis    synthesized    implants    silica    secondly    proof    burden    animal    mg2    implantable    synovial    progresses    damaged    repair    salt    inorganic    fuel    metabolic    commercializable    polyp    symptomatic    guiding    natural    grant    regeneration    cartilage    benefit    microparticles    tissues    morphogenetic    biosilica    splinters    fragments    beneficial    dual    effect    reducing    fluid    structure    latter    organic    reaction    oa    consisting    innovative    bidirectional    painful    polymers    amorphous    first    dissolution    platelets    citizens    inclusive    therapies    fold    damage    society    connective    joints    of    injection    integrity    injectable    ca2    polymer    bone    disclosed    polyphosphate    hybrid    acts    hyaluronic    combine    aging    forming    injections    elicits    acid    268476    cells    dissolve    osteoarthritis    form    surrounding    accumulate    erc    amplify   

Project "ArthroDUR" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ 

Organization address
address: Langenbeckstrasse 1
city: Mainz
postcode: 55131
website: http://www.um-mainz.de/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-09-01   to  2019-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAETSMEDIZIN DER JOHANNES GUTENBERG-UNIVERSITAET MAINZ DE (Mainz) coordinator 150˙000.00

Map

 Project objective

Osteoarthritis (OA) is the most common form of arthritis of the joints, affecting over 70 million EU citizens. At present, no cure for OA is available; only symptomatic therapies may help to ameliorate this painful disorder. OA affects the integrity of the cartilage and progresses to an increased damage in its surrounding tissues, inclusive bone, and to inflammation of the synovial tissue. The latter reaction is caused by an accumulation of bone splinters. The therapy of choice would be – if available – bidirectional: first, regeneration of the damaged cartilage (by implants) and second, dissolution of the bone fragments (by injections). This proposal presents for the first time this two-fold solution.

Within my ERC Advanced Grant “BIOSILICA” (No. 268476) we disclosed that biosilica elicits morphogenetic activity in cells involved in connective tissue formation. The effect of silica is augmented by another natural inorganic polymer, by polyphosphate (polyP), which is synthesized in most animal cells, especially blood platelets that accumulate in damaged bone and cartilage. polyP acts as “metabolic fuel” for the synthesis of the extracellular inorganic and organic skeletal and cartilage tissues. Our strategy is to combine and to amplify the beneficial properties of these two polymers, biosilica and polyP, their morphogenetic activity with their structure-forming/guiding activity, by applying hybrid microparticles, consisting of silica and polyP. The proposed project will provide the proof-of-concept of this dual strategy, using silica and the amorphous Mg2/Ca2 salt of polyP together with hyaluronic acid, to dissolve firstly existing bone splinters in the synovial fluid (by injection), reducing the painful joint burden in osteoarthritis, and secondly to repair damaged cartilage with polyP/silica implants.

This innovative material, injectable and implantable, will be developed to commercializable products for the benefit of the aging society.

 Publications

year authors and title journal last update
List of publications.
2018 Werner Müller, Meik Neufurth, Shunfeng Wang, Maximilian Ackermann, Rafael Muñoz-Espí, Qingling Feng, Qiang Lu, Heinz Schröder, Xiaohong Wang
Amorphous, Smart, and Bioinspired Polyphosphate Nano/Microparticles: A Biomaterial for Regeneration and Repair of Osteo-Articular Impairments In-Situ
published pages: 427, ISSN: 1422-0067, DOI: 10.3390/ijms19020427
International Journal of Molecular Sciences 19/2 2019-10-08
2018 Wang XH, Schröder HC, Müller WEG
Amorphous polyphosphate, a smart bioinspired nano-/bio-material for bone and cartilage regeneration: Towards a new paradigm in tissue engineering
published pages: 2385-2412, ISSN: 2050-7518, DOI: 10.1039/c8tb00241j
J Mat Chem B 6 2019-10-08
2019 Emad Tolba, Xiaohong Wang, Maximilian Ackermann, Meik Neufurth, Rafael Muñoz-Espí, Heinz C. Schröder, Werner E. G. Müller
In Situ Polyphosphate Nanoparticle Formation in Hybrid Poly(vinyl alcohol)/Karaya Gum Hydrogels: A Porous Scaffold Inducing Infiltration of Mesenchymal Stem Cells
published pages: 1801452, ISSN: 2198-3844, DOI: 10.1002/advs.201801452
Advanced Science 6/2 2019-10-08
2017 Müller WEG, Wang S, Wiens M, Neufurth M, Ackermann M, Relkovic D, Kokkinopoulou M, Feng Q, Schröder HC, Wang XH
Uptake of polyphosphate microparticles in vitro (SaOS-2 and HUVEC cells) followed by an increase of the intracellular ATP pool size
published pages: e0188977, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0188977
PLoS ONE 12 2019-05-23

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