EU H2020 Project "NEBUFLOX (Making it happen - Scalable biphasic reactions using a nebulizer-driven..)": description, partecipants, costs and EC-fundings

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NebuFlox project word cloud

Explore the words cloud of the NebuFlox project. It provides you a very rough idea of what is the project "NebuFlox" about.

start materials scales benign pi obvious combined chemical excited sought solubility fine excellent technologies expert representing continuous curtailed cloud pilot droplets readily severely oxygen usefulness seek look advisory chemistry prevailed industrial mentor light biphasic waste flow prospects superbly form penetration efficient projecting extremely enlarging erc latest remarkable explore pharmaceutical synthesis astrazeneca reactor herein automation small commercialization transformed reactions chemicals filled pot had fix exceptionally made automate dimension plan operations chamber nebulizer diversity good air solutions suited realization global relevance breakthrough power amplify seemed structures sustainable delineated pursue giant straightforward prototype accessible grant innovative poor act castrate frameworks plant exploited team proving original worked

Project "NebuFlox" data sheet

The following table provides information about the project.

Coordinator	PANEPISTIMIO KRITIS Organization address address: UNIVERSITY CAMPUS GALLOS city: RETHIMNO postcode: 74100 website: www.uoc.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Greece [EL]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2018
Duration (year-month-day)	from 2018-01-01 to 2019-06-30

#	participants	country	role	EC contrib. [€]
1	PANEPISTIMIO KRITIS	EL (RETHIMNO)	coordinator	150˙000.00

PANEPISTIMIO KRITIS

EL (RETHIMNO)

coordinator

150˙000.00

Project objective

The original ERC grant focused on proving the power that oxygen from the air had in synthesis when its light-excited state was exploited. During the ERC program, we were able to show how simple & readily accessible start materials could be transformed into high value-high interest chemicals through straightforward “one pot” operations. We were also able to show that the diversity of structures accessible using this chemistry is remarkable. Furthermore, it is highly sustainable; representing a very efficient, benign & extremely low waste approach to the production of sought-after chemical frameworks. However, one problem prevailed. While it worked exceptionally well on a small research scale, its overall usefulness and its industrial relevance were severely curtailed by scale-up issues, even when the latest continuous flow technologies were applied. The need to achieve good light penetration, combined with the poor solubility of oxygen, seemed to castrate the potential of this chemistry to provide global solutions. A key breakthrough was made towards the end of the ERC program with the realization that creating and projecting a cloud (using a nebulizer to make fine droplets) into a light filled chamber could solve ALL the problems and lead to large scale reactions. With the current proposal, we seek to explore and fully automate this highly innovative nebulizer process in order to develop a robust prototype reactor with excellent prospects for further dimension enlarging (to industrial pilot plant scales & beyond). Furthermore, it is obvious that this “nebulizer fix” may also be superbly suited to other biphasic reactions. Our plan has the support of pharmaceutical giant AstraZeneca in the form of an automation expert who will act as mentor to the program. The PI & the advisory team will pursue a number of different commercialization opportunities delineated herein and look at how best to exploit and amplify the impact of the extremely efficient prototype reactor(s).

Publications

List of publications.
year	authors and title	journal	last update
2018	Georgios I. Ioannou, Tamsyn Montagnon, Dimitris Kalaitzakis, Spiros A. Pergantis, Georgios Vassilikogiannakis One-Pot Synthesis of Diverse Î³-Lactam Scaffolds Facilitated by a Nebulizer-Based Continuous Flow Photoreactor published pages: 860-864, ISSN: 2367-0932, DOI: 10.1002/cptc.201800068	ChemPhotoChem 2/10	2019-11-06

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The information about "NEBUFLOX" are provided by the European Opendata Portal: CORDIS opendata.

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