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DORMANTOOCYTE SIGNED

Understanding the Balbiani body: A super-organelle linked to dormancy in oocytes

Total Cost €

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EC-Contrib. €

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Partnership

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 DORMANTOOCYTE project word cloud

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genome    function    machinery    reveal    membrane    protective    structure    mature    imaging    techniques    shown    matures    time    mammals    avenues    insights    dormancy    cage    complementary    periods    stay    ageing    forms    frogs    me    complement    human    ease    age    species    protect    oocytes    mitochondria    cell    genetic    specialised    start    virtually    generally    bound    metabolic    biology    employ    compartment    unanswered    disassemble    mice    embryo    body    experiments    proteomics    survive    decades    surprisingly    fundamental    give    cells    contains    questions    housekeeping    germ    organisation    relationship    little    nature    regulation    biochemical    vertebrates    continuity    disappears    dormant    organism    oocyte    led    release    female    handling    nutrients    mechanisms    remarkable    retain    perturbations    young    combine    humans    physiological    structures    balbiani    organelles    amyloid    die    vertebrate    fertilisation    physiology   

Project "DORMANTOOCYTE" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙381˙286 €
 EC max contribution 1˙381˙286 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 1˙381˙286.00

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 Project objective

Female germ cells, oocytes, are highly specialised cells. They ensure the continuity of species by providing the female genome and mitochondria along with most of the nutrients and housekeeping machinery the early embryo needs after fertilisation. Oocytes are remarkable in their ability to survive for long periods of time, up to 50 years in humans, and retain the ability to give rise to a young organism while other cells age and die. Surprisingly little is known about oocyte dormancy. A key feature of dormant oocytes of virtually all vertebrates is the presence of a Balbiani body, which is a non-membrane bound compartment that contains most of the organelles in dormant oocytes and disappears as the oocyte matures.

The goal of this proposal is to combine genetic and biochemical perturbations with imaging and the state of the art proteomics techniques to reveal the mechanisms dormant oocytes employ to remain viable. My previous research has shown that the Balbiani body forms an amyloid-like cage around organelles that could be protective. This has led me to identify the large number of unanswered questions about the cell biology of a dormant oocyte. In this proposal, we will study three of these questions: 1) What is the metabolic nature of organelles in dormant oocytes? 2) How does the Balbiani body disassemble and release the complement of organelles when oocytes start to mature? 3) What is the structure and function of the Balbiani body in mammals? We will use oocytes from two vertebrate species, frogs and mice, which are complementary for their ease of handling and relationship to human physiology.

By studying the Balbiani body, this proposal will provide fundamental insights into organisation and function of organelles in oocytes and the regulation of physiological amyloid-like structures. More generally, the proposed experiments open up new avenues into the mechanisms that protect organelles from ageing and how oocytes stay dormant for many decades.

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The information about "DORMANTOOCYTE" are provided by the European Opendata Portal: CORDIS opendata.

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