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DORMANTOOCYTE SIGNED

Understanding the Balbiani body: A super-organelle linked to dormancy in oocytes

Total Cost €

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EC-Contrib. €

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Partnership

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 DORMANTOOCYTE project word cloud

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protect    perturbations    proteomics    release    retain    humans    disassemble    cage    mechanisms    complement    organism    structures    organelles    ease    combine    unanswered    function    female    cells    little    mice    decades    matures    bound    young    nutrients    mature    organisation    mammals    specialised    vertebrate    periods    embryo    insights    germ    shown    age    body    frogs    genetic    compartment    led    protective    dormant    virtually    contains    nature    avenues    fundamental    questions    oocyte    structure    survive    genome    stay    housekeeping    ageing    mitochondria    fertilisation    start    biology    oocytes    forms    balbiani    time    physiology    physiological    biochemical    die    techniques    regulation    me    dormancy    continuity    reveal    disappears    employ    amyloid    surprisingly    give    handling    cell    generally    experiments    complementary    species    imaging    membrane    vertebrates    machinery    remarkable    relationship    metabolic    human   

Project "DORMANTOOCYTE" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙381˙286 €
 EC max contribution 1˙381˙286 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 1˙381˙286.00

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 Project objective

Female germ cells, oocytes, are highly specialised cells. They ensure the continuity of species by providing the female genome and mitochondria along with most of the nutrients and housekeeping machinery the early embryo needs after fertilisation. Oocytes are remarkable in their ability to survive for long periods of time, up to 50 years in humans, and retain the ability to give rise to a young organism while other cells age and die. Surprisingly little is known about oocyte dormancy. A key feature of dormant oocytes of virtually all vertebrates is the presence of a Balbiani body, which is a non-membrane bound compartment that contains most of the organelles in dormant oocytes and disappears as the oocyte matures.

The goal of this proposal is to combine genetic and biochemical perturbations with imaging and the state of the art proteomics techniques to reveal the mechanisms dormant oocytes employ to remain viable. My previous research has shown that the Balbiani body forms an amyloid-like cage around organelles that could be protective. This has led me to identify the large number of unanswered questions about the cell biology of a dormant oocyte. In this proposal, we will study three of these questions: 1) What is the metabolic nature of organelles in dormant oocytes? 2) How does the Balbiani body disassemble and release the complement of organelles when oocytes start to mature? 3) What is the structure and function of the Balbiani body in mammals? We will use oocytes from two vertebrate species, frogs and mice, which are complementary for their ease of handling and relationship to human physiology.

By studying the Balbiani body, this proposal will provide fundamental insights into organisation and function of organelles in oocytes and the regulation of physiological amyloid-like structures. More generally, the proposed experiments open up new avenues into the mechanisms that protect organelles from ageing and how oocytes stay dormant for many decades.

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The information about "DORMANTOOCYTE" are provided by the European Opendata Portal: CORDIS opendata.

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