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DORMANTOOCYTE SIGNED

Understanding the Balbiani body: A super-organelle linked to dormancy in oocytes

Total Cost €

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EC-Contrib. €

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Partnership

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 DORMANTOOCYTE project word cloud

Explore the words cloud of the DORMANTOOCYTE project. It provides you a very rough idea of what is the project "DORMANTOOCYTE" about.

structures    me    regulation    shown    complementary    vertebrates    relationship    germ    give    physiology    nutrients    unanswered    disassemble    balbiani    young    female    virtually    machinery    cell    mechanisms    employ    vertebrate    insights    species    structure    time    body    organisation    release    little    genome    techniques    fundamental    forms    housekeeping    proteomics    cells    reveal    combine    biology    embryo    compartment    mice    perturbations    mammals    mitochondria    age    ease    organism    die    protect    amyloid    oocytes    retain    ageing    human    complement    surprisingly    handling    mature    biochemical    dormant    decades    generally    function    avenues    bound    humans    led    metabolic    membrane    stay    frogs    disappears    specialised    experiments    oocyte    periods    start    questions    cage    imaging    dormancy    continuity    fertilisation    protective    physiological    contains    genetic    nature    remarkable    matures    organelles    survive   

Project "DORMANTOOCYTE" data sheet

The following table provides information about the project.

Coordinator
FUNDACIO CENTRE DE REGULACIO GENOMICA 

Organization address
address: CARRER DOCTOR AIGUADER 88
city: BARCELONA
postcode: 8003
website: www.crg.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 1˙381˙286 €
 EC max contribution 1˙381˙286 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2023-02-28

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FUNDACIO CENTRE DE REGULACIO GENOMICA ES (BARCELONA) coordinator 1˙381˙286.00

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 Project objective

Female germ cells, oocytes, are highly specialised cells. They ensure the continuity of species by providing the female genome and mitochondria along with most of the nutrients and housekeeping machinery the early embryo needs after fertilisation. Oocytes are remarkable in their ability to survive for long periods of time, up to 50 years in humans, and retain the ability to give rise to a young organism while other cells age and die. Surprisingly little is known about oocyte dormancy. A key feature of dormant oocytes of virtually all vertebrates is the presence of a Balbiani body, which is a non-membrane bound compartment that contains most of the organelles in dormant oocytes and disappears as the oocyte matures.

The goal of this proposal is to combine genetic and biochemical perturbations with imaging and the state of the art proteomics techniques to reveal the mechanisms dormant oocytes employ to remain viable. My previous research has shown that the Balbiani body forms an amyloid-like cage around organelles that could be protective. This has led me to identify the large number of unanswered questions about the cell biology of a dormant oocyte. In this proposal, we will study three of these questions: 1) What is the metabolic nature of organelles in dormant oocytes? 2) How does the Balbiani body disassemble and release the complement of organelles when oocytes start to mature? 3) What is the structure and function of the Balbiani body in mammals? We will use oocytes from two vertebrate species, frogs and mice, which are complementary for their ease of handling and relationship to human physiology.

By studying the Balbiani body, this proposal will provide fundamental insights into organisation and function of organelles in oocytes and the regulation of physiological amyloid-like structures. More generally, the proposed experiments open up new avenues into the mechanisms that protect organelles from ageing and how oocytes stay dormant for many decades.

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The information about "DORMANTOOCYTE" are provided by the European Opendata Portal: CORDIS opendata.

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