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MICRONEX SIGNED

Microbioreactor platforms as in vivo-like systems to probe the role of Neuroblastoma-derived Exosomes in cancer dissemination

Total Cost €

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EC-Contrib. €

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Partnership

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 MICRONEX project word cloud

Explore the words cloud of the MICRONEX project. It provides you a very rough idea of what is the project "MICRONEX" about.

shedding    unexplored    physics    space    hypothesize    niches    env    microenvironment    reside    limitation    difficult    resolved    biologically    fate    decoding    translate    cure    local    predicting    mechanisms    health    interactions    bridge    situation    secreted    vivo    revolutionize    sound    gradients    organs    culture    engineering    dynamic    language    conditioning    technologies    engineers    phenomena    progression    scenarios    edge    light    sciences    prognosis    reconstruct    multifactorial    fast    tissues    malignant    techniques    laboratory    model    thought    limitations    medical    human    disease    ground    cells    brs    platforms    models    poorly    nbs    bodies    parallelized    vitro    exosomes    laws    milieu    regulating    neuroblastoma    reshape    previously    felt    heterogeneous    comfort    nb    generate    complexity    tumors    zones    concentration    extremely    performing    standard    microbioreactors    solid    tumor    function    discoveries    principles    distant    experiments    time    mathematics    life    reconstructing    mu    difficulty    actively    readouts    induce    cancer    thermodynamics    leaders    tools    lacking    completely    biological    scientists    pediatric    gap   

Project "MICRONEX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙446˙250 €
 EC max contribution 1˙446˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 1˙446˙250.00

Map

 Project objective

Engineers can actively contribute to fields thought to be out of their “comfort zones”. We can be leaders of discoveries that translate into advances in the understanding of disease and improving human health. Engineers might use different language and tools than Life Sciences Scientists but we find a common ground, as the laws of Thermodynamics, Physics, and Mathematics also apply to biological phenomena. The development of microbioreactors (μBRs) reconstructing biologically sound niches can revolutionize medical research. In our bodies cells reside in a complex milieu, the microenvironment (μEnv), regulating their fate and function. Most of this complexity is lacking in standard laboratory models, leading to readouts poorly predicting the in vivo situation. This is particularly felt in cancer research, as tumors are extremely heterogeneous and capable of conditioning both the local μEnv and distant organs. Neuroblastoma (NB) is the most common and difficult to cure pediatric malignant solid tumor. Secreted exosomes are means by which NBs reshape their μEnv and induce local and long-range changes in cells, regulating progression and prognosis. But the mechanisms involved are yet not completely understood. A major limitation is the difficulty to model in vitro the local in vivo dynamic μEnv. We hypothesize that μBRs exploiting classical engineering principles will solve the limitations of existing classical culture models. We propose to develop platforms and test their edge over classical approaches in decoding the role of exosomes and μEnv in NB. Our μBRs generate time and space-resolved concentration gradients, support fast dynamic changes and reconstruct complex interactions between cells and tissues while performing multifactorial and parallelized experiments. We expect that our technologies will bridge the gap between in vitro techniques and in vivo biological phenomena leading to significant and novel results, shedding light on previously unexplored scenarios.

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The information about "MICRONEX" are provided by the European Opendata Portal: CORDIS opendata.

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