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MICRONEX SIGNED

Microbioreactor platforms as in vivo-like systems to probe the role of Neuroblastoma-derived Exosomes in cancer dissemination

Total Cost €

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EC-Contrib. €

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Partnership

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 MICRONEX project word cloud

Explore the words cloud of the MICRONEX project. It provides you a very rough idea of what is the project "MICRONEX" about.

unexplored    human    mu    biologically    progression    laboratory    nbs    light    hypothesize    parallelized    reconstruct    bodies    thermodynamics    env    sciences    solid    limitations    multifactorial    difficulty    organs    scenarios    vivo    comfort    physics    actively    health    resolved    thought    generate    leaders    medical    laws    readouts    life    function    cells    conditioning    translate    poorly    tumor    bridge    language    situation    milieu    prognosis    discoveries    platforms    principles    space    time    interactions    reconstructing    complexity    tumors    previously    performing    malignant    niches    induce    vitro    extremely    phenomena    microbioreactors    predicting    lacking    techniques    pediatric    reshape    local    heterogeneous    distant    sound    engineering    microenvironment    mechanisms    fast    shedding    ground    concentration    revolutionize    technologies    experiments    disease    tissues    model    neuroblastoma    scientists    cancer    culture    gradients    cure    models    gap    mathematics    felt    engineers    edge    standard    biological    dynamic    difficult    reside    secreted    zones    regulating    completely    tools    decoding    limitation    fate    brs    nb    exosomes   

Project "MICRONEX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙446˙250 €
 EC max contribution 1˙446˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 1˙446˙250.00

Map

 Project objective

Engineers can actively contribute to fields thought to be out of their “comfort zones”. We can be leaders of discoveries that translate into advances in the understanding of disease and improving human health. Engineers might use different language and tools than Life Sciences Scientists but we find a common ground, as the laws of Thermodynamics, Physics, and Mathematics also apply to biological phenomena. The development of microbioreactors (μBRs) reconstructing biologically sound niches can revolutionize medical research. In our bodies cells reside in a complex milieu, the microenvironment (μEnv), regulating their fate and function. Most of this complexity is lacking in standard laboratory models, leading to readouts poorly predicting the in vivo situation. This is particularly felt in cancer research, as tumors are extremely heterogeneous and capable of conditioning both the local μEnv and distant organs. Neuroblastoma (NB) is the most common and difficult to cure pediatric malignant solid tumor. Secreted exosomes are means by which NBs reshape their μEnv and induce local and long-range changes in cells, regulating progression and prognosis. But the mechanisms involved are yet not completely understood. A major limitation is the difficulty to model in vitro the local in vivo dynamic μEnv. We hypothesize that μBRs exploiting classical engineering principles will solve the limitations of existing classical culture models. We propose to develop platforms and test their edge over classical approaches in decoding the role of exosomes and μEnv in NB. Our μBRs generate time and space-resolved concentration gradients, support fast dynamic changes and reconstruct complex interactions between cells and tissues while performing multifactorial and parallelized experiments. We expect that our technologies will bridge the gap between in vitro techniques and in vivo biological phenomena leading to significant and novel results, shedding light on previously unexplored scenarios.

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The information about "MICRONEX" are provided by the European Opendata Portal: CORDIS opendata.

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