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MICRONEX SIGNED

Microbioreactor platforms as in vivo-like systems to probe the role of Neuroblastoma-derived Exosomes in cancer dissemination

Total Cost €

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EC-Contrib. €

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Partnership

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 MICRONEX project word cloud

Explore the words cloud of the MICRONEX project. It provides you a very rough idea of what is the project "MICRONEX" about.

thermodynamics    solid    microenvironment    laws    parallelized    language    zones    brs    secreted    reshape    bridge    limitations    difficulty    scientists    technologies    actively    unexplored    concentration    malignant    neuroblastoma    vivo    organs    thought    biological    shedding    generate    space    difficult    life    reside    limitation    env    engineering    mechanisms    previously    induce    model    engineers    biologically    multifactorial    tumors    disease    physics    extremely    decoding    lacking    standard    niches    health    light    mu    progression    nbs    laboratory    pediatric    heterogeneous    time    edge    reconstruct    gradients    regulating    experiments    cancer    dynamic    human    situation    hypothesize    felt    bodies    tumor    phenomena    comfort    mathematics    tools    poorly    readouts    local    revolutionize    interactions    milieu    nb    scenarios    prognosis    microbioreactors    discoveries    function    tissues    completely    exosomes    leaders    ground    models    platforms    resolved    predicting    performing    sciences    principles    distant    complexity    sound    culture    reconstructing    medical    vitro    techniques    translate    cells    conditioning    fate    fast    cure    gap   

Project "MICRONEX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙446˙250 €
 EC max contribution 1˙446˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 1˙446˙250.00

Map

 Project objective

Engineers can actively contribute to fields thought to be out of their “comfort zones”. We can be leaders of discoveries that translate into advances in the understanding of disease and improving human health. Engineers might use different language and tools than Life Sciences Scientists but we find a common ground, as the laws of Thermodynamics, Physics, and Mathematics also apply to biological phenomena. The development of microbioreactors (μBRs) reconstructing biologically sound niches can revolutionize medical research. In our bodies cells reside in a complex milieu, the microenvironment (μEnv), regulating their fate and function. Most of this complexity is lacking in standard laboratory models, leading to readouts poorly predicting the in vivo situation. This is particularly felt in cancer research, as tumors are extremely heterogeneous and capable of conditioning both the local μEnv and distant organs. Neuroblastoma (NB) is the most common and difficult to cure pediatric malignant solid tumor. Secreted exosomes are means by which NBs reshape their μEnv and induce local and long-range changes in cells, regulating progression and prognosis. But the mechanisms involved are yet not completely understood. A major limitation is the difficulty to model in vitro the local in vivo dynamic μEnv. We hypothesize that μBRs exploiting classical engineering principles will solve the limitations of existing classical culture models. We propose to develop platforms and test their edge over classical approaches in decoding the role of exosomes and μEnv in NB. Our μBRs generate time and space-resolved concentration gradients, support fast dynamic changes and reconstruct complex interactions between cells and tissues while performing multifactorial and parallelized experiments. We expect that our technologies will bridge the gap between in vitro techniques and in vivo biological phenomena leading to significant and novel results, shedding light on previously unexplored scenarios.

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The information about "MICRONEX" are provided by the European Opendata Portal: CORDIS opendata.

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