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MICRONEX SIGNED

Microbioreactor platforms as in vivo-like systems to probe the role of Neuroblastoma-derived Exosomes in cancer dissemination

Total Cost €

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EC-Contrib. €

0

Partnership

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 MICRONEX project word cloud

Explore the words cloud of the MICRONEX project. It provides you a very rough idea of what is the project "MICRONEX" about.

culture    ground    situation    nb    light    predicting    shedding    multifactorial    health    organs    tumors    thought    human    limitations    pediatric    scientists    vivo    platforms    scenarios    decoding    principles    gradients    poorly    extremely    secreted    brs    thermodynamics    resolved    mechanisms    tumor    biological    limitation    bridge    technologies    interactions    medical    difficulty    reconstructing    regulating    fate    cure    concentration    neuroblastoma    function    comfort    mu    parallelized    generate    model    language    bodies    milieu    sciences    reshape    difficult    niches    techniques    heterogeneous    env    microenvironment    life    previously    standard    reside    leaders    engineering    distant    microbioreactors    hypothesize    tools    malignant    time    reconstruct    physics    complexity    performing    laws    readouts    zones    laboratory    engineers    prognosis    revolutionize    cancer    biologically    translate    models    felt    gap    conditioning    dynamic    fast    sound    discoveries    tissues    vitro    actively    lacking    space    local    cells    edge    induce    completely    experiments    progression    disease    phenomena    unexplored    mathematics    nbs    exosomes    solid   

Project "MICRONEX" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITA DEGLI STUDI DI PADOVA 

Organization address
address: VIA 8 FEBBRAIO 2
city: PADOVA
postcode: 35122
website: www.unipd.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Total cost 1˙446˙250 €
 EC max contribution 1˙446˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITA DEGLI STUDI DI PADOVA IT (PADOVA) coordinator 1˙446˙250.00

Map

 Project objective

Engineers can actively contribute to fields thought to be out of their “comfort zones”. We can be leaders of discoveries that translate into advances in the understanding of disease and improving human health. Engineers might use different language and tools than Life Sciences Scientists but we find a common ground, as the laws of Thermodynamics, Physics, and Mathematics also apply to biological phenomena. The development of microbioreactors (μBRs) reconstructing biologically sound niches can revolutionize medical research. In our bodies cells reside in a complex milieu, the microenvironment (μEnv), regulating their fate and function. Most of this complexity is lacking in standard laboratory models, leading to readouts poorly predicting the in vivo situation. This is particularly felt in cancer research, as tumors are extremely heterogeneous and capable of conditioning both the local μEnv and distant organs. Neuroblastoma (NB) is the most common and difficult to cure pediatric malignant solid tumor. Secreted exosomes are means by which NBs reshape their μEnv and induce local and long-range changes in cells, regulating progression and prognosis. But the mechanisms involved are yet not completely understood. A major limitation is the difficulty to model in vitro the local in vivo dynamic μEnv. We hypothesize that μBRs exploiting classical engineering principles will solve the limitations of existing classical culture models. We propose to develop platforms and test their edge over classical approaches in decoding the role of exosomes and μEnv in NB. Our μBRs generate time and space-resolved concentration gradients, support fast dynamic changes and reconstruct complex interactions between cells and tissues while performing multifactorial and parallelized experiments. We expect that our technologies will bridge the gap between in vitro techniques and in vivo biological phenomena leading to significant and novel results, shedding light on previously unexplored scenarios.

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The information about "MICRONEX" are provided by the European Opendata Portal: CORDIS opendata.

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