Opendata, web and dolomites

TRIPLECON

Triple negative breast cancer control through synergistic inhibition of EGFR and CDK9 signaling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 TRIPLECON project word cloud

Explore the words cloud of the TRIPLECON project. It provides you a very rough idea of what is the project "TRIPLECON" about.

outcomes    instance    family    disease    mouse    compensatory    combinatorial    er    poc    clinically    disproportionally    bc    epidermal    chemotherapies    safe    lapatinib    pdx    receptor    cell    intrinsic    molecular    agent    express    grant    models    trials    egfr    approved    lines    322737    stalling    erc    clinic    translate    aggressive    giving    targetable    block    combination    cytotoxic    dysregulated    signaling    triple    strategy    preliminary    drive    synergized    inhibitor    causing    forms    15    80    xenograft    patients    revealed    dual    treat    benefit    overexpressed    accounting    mainstay    drug    cyclin    synergistic    inhibit    dependent    therapies    therapy    breast    patient    cdk9    proof    20    pr    single    cancer    death    clinical    proliferation    ongoing    attempted    receptors    tnbc    unsatisfactory    striving    treatment    vivo    her2    poor    explore    benefiting    negative    owing    envisage    kinase    pharmacological    successful    strikingly    resistance    concomitantly   

Project "TRIPLECON" data sheet

The following table provides information about the project.

Coordinator
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM 

Organization address
address: DR MOLEWATERPLEIN 40
city: ROTTERDAM
postcode: 3015 GD
website: www.erasmusmc.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-10-01   to  2018-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM NL (ROTTERDAM) coordinator 90˙075.00
2    UNIVERSITEIT LEIDEN NL (LEIDEN) participant 59˙925.00

Map

 Project objective

'Triple negative breast cancer (TNBC) is an aggressive disease, accounting for 15-20% of breast cancer cases, but disproportionally causing breast cancer-related death. TNBC does not express the targetable receptors ER, PR, and HER2 that are known to drive other forms of breast cancer. Mainstay practice for TNBC in the clinic is to treat with non-targeted cytotoxic chemotherapies. Long-term outcomes are however still poor, most likely owing to intrinsic drug resistance. Clinical trials have attempted to explore molecular targeted therapies to block dysregulated growth factor receptors in TNBC, for instance, epidermal growth factor receptor (EGFR), as it is overexpressed in ~80% of TNBC. Yet, giving the long-standing availability of clinically approved EGFR-targeted therapies, such as lapatinib, the clinical benefit of single agent therapy is unsatisfactory, owing to the compensatory dysregulated signaling pathways. In our ongoing ERC – Advanced Grant Triple-BC (#322737) we are striving to explore combinatorial molecular targeted therapies to concomitantly block the identified dysregulated signaling pathways. Our preliminary work revealed that an inhibitor targeting cyclin-dependent kinase 9 (CDK9) strikingly synergized with targeting EGFR receptor family signaling to inhibit cell proliferation of TNBC cell lines. The overall goal of this PoC project is to exploit this novel finding and provide proof-of-concept evidence that stalling CDK9 signaling may enable successful targeted combination therapy in TNBC. Therefore, the specific objective is to assess the pharmacological response of dual EGFR-CDK9 targeting in TNBC patient-derived xenograft (PDX) mouse models in vivo. We envisage that this PoC project will translate our identified successful synergistic treatment into an effective future novel and safe combinatorial targeting strategy benefiting TNBC patients.'

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TRIPLECON" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "TRIPLECON" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More  

TRUST (2018)

Truth and Semantics

Read More  

Resonances (2019)

Resonances and Zeta Functions in Smooth Ergodic Theory and Geometry

Read More