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The following table provides information about the project.
THE UNIVERSITY OF MANCHESTER
|Coordinator Country||United Kingdom [UK]|
|Total cost||1˙494˙777 €|
|EC max contribution||1˙494˙777 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-01-01 to 2022-12-31|
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|1||THE UNIVERSITY OF MANCHESTER||UK (MANCHESTER)||coordinator||1˙494˙777.00|
Nitrogen-containing compounds underpin every aspect of our daily life as they form the structural basis of almost all pharmaceuticals, agrochemicals, food additives and materials. The invention of methods for the formation of bonds between C and N atoms is of strategic importance for the discovery and evolution of molecules with direct implications on the quality of our lives. Despite this fundamental relevance, forming C–N bonds is still a very challenging task. This proposal aims to deliver transformative advances for the development of new efficient and selective strategies for the synthesis of N-containing molecules by harnessing visible-light as inexpensive and sustainable source of energy. I aim to challenge preconceptions about the field of organic chemistry and to develop innovative methods to control, modulate and transform the reactivity of nitrogen-centered radicals (NCRs), an entire class of reactive intermediates for which there are only limited applications in modern organic chemistry. My research group has developed two novel visible-light-mediated ways of generating NCRs, and I aim to: (1) Harness and explore the unique features of visible-light-mediated transformations to provide novel multicomponent reactions of NCRs. (2) Establish NCRs as viable partners in asymmetric photoredox catalysis and use them for the easy construction of complex molecules with defined 3D shapes. (3) Merge the visible-light generation of NCRs with organocatalysis to enable novel dual catalytic asymmetric protocols. (4) Combine the NCRs with transition metal catalysis and discover unprecedented transformations that go beyond photoredox catalysis and transition metal catalysis alone. This cohesive and innovative approach will develop new tools essential for the assembly of complex molecules with biological, therapeutic and agrochemical properties. Overall this project will transform the way C–N bonds are forged and how N-containing molecules are assembled.
|year||authors and title||journal||last update|
David C. Marcote, Rosie Street-Jeakings, Elizabeth Dauncey, James J. Douglas, Alessandro Ruffoni, Daniele Leonori
Photoinduced decarboxylative azidation of cyclic amino acids
published pages: 1839-1842, ISSN: 1477-0520, DOI: 10.1039/c8ob02702a
|Organic & Biomolecular Chemistry 17/7||2019-09-05|
Sara P. Morcillo, Elizabeth M. Dauncey, Ji Hye Kim, James J. Douglas, Nadeem S. Sheikh, Daniele Leonori
Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals
published pages: 12945-12949, ISSN: 1433-7851, DOI: 10.1002/anie.201807941
|Angewandte Chemie International Edition 57/39||2019-09-05|
Alessandro Ruffoni, Fabio JuliÃ¡, Thomas D. Svejstrup, Alastair J. McMillan, James J. Douglas, Daniele Leonori
Practical and regioselective amination of arenes using alkyl amines
published pages: 426-433, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0254-5
|Nature Chemistry 11/5||2019-09-05|
Lucrezia Angelini, Jacob Davies, Marco Simonetti, Laia Maletâ€…Sanz, Nadeem S. Sheikh, Daniele Leonori
Reaction of Nitrogen-Radicals with Organometallics Under Ni-Catalysis: N-Arylations and Amino-Functionalization Cascades
published pages: 5003-5007, ISSN: 1433-7851, DOI: 10.1002/anie.201900510
|Angewandte Chemie International Edition 58/15||2019-09-05|
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