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Novel Blueprints for the Visible-Light-Mediated Assembly of C–N Bonds via Nitrogen Radicals

Total Cost €


EC-Contrib. €






 NEBULAR project word cloud

Explore the words cloud of the NEBULAR project. It provides you a very rough idea of what is the project "NEBULAR" about.

transform    therapeutic    harness    invention    catalysis    discovery    reactive    structural    evolution    bonds    intermediates    materials    light    molecules    inexpensive    fundamental    biological    organic    strategic    despite    harnessing    form    transition    shapes    assembled    reactivity    unprecedented    generating    compounds    strategies    organocatalysis    pharmaceuticals    modern    sustainable    preconceptions    underpin    asymmetric    catalytic    forged    containing    chemistry    basis    transformative    assembly    transformations    selective    visible    alone    cohesive    group    life    relevance    forming    direct    efficient    source    entire    discover    multicomponent    limited    explore    energy    ways    radicals    construction    daily    tools    protocols    agrochemicals    additives    ncrs    combine    implications    mediated    food    modulate    centered    class    nitrogen    quality    atoms    innovative    dual    almost    merge    metal    reactions    synthesis    agrochemical    photoredox    3d    lives    generation   

Project "NEBULAR" data sheet

The following table provides information about the project.


Organization address
address: OXFORD ROAD
postcode: M13 9PL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙494˙777 €
 EC max contribution 1˙494˙777 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 1˙494˙777.00


 Project objective

Nitrogen-containing compounds underpin every aspect of our daily life as they form the structural basis of almost all pharmaceuticals, agrochemicals, food additives and materials. The invention of methods for the formation of bonds between C and N atoms is of strategic importance for the discovery and evolution of molecules with direct implications on the quality of our lives. Despite this fundamental relevance, forming C–N bonds is still a very challenging task. This proposal aims to deliver transformative advances for the development of new efficient and selective strategies for the synthesis of N-containing molecules by harnessing visible-light as inexpensive and sustainable source of energy. I aim to challenge preconceptions about the field of organic chemistry and to develop innovative methods to control, modulate and transform the reactivity of nitrogen-centered radicals (NCRs), an entire class of reactive intermediates for which there are only limited applications in modern organic chemistry. My research group has developed two novel visible-light-mediated ways of generating NCRs, and I aim to: (1) Harness and explore the unique features of visible-light-mediated transformations to provide novel multicomponent reactions of NCRs. (2) Establish NCRs as viable partners in asymmetric photoredox catalysis and use them for the easy construction of complex molecules with defined 3D shapes. (3) Merge the visible-light generation of NCRs with organocatalysis to enable novel dual catalytic asymmetric protocols. (4) Combine the NCRs with transition metal catalysis and discover unprecedented transformations that go beyond photoredox catalysis and transition metal catalysis alone. This cohesive and innovative approach will develop new tools essential for the assembly of complex molecules with biological, therapeutic and agrochemical properties. Overall this project will transform the way C–N bonds are forged and how N-containing molecules are assembled.


year authors and title journal last update
List of publications.
2019 David C. Marcote, Rosie Street-Jeakings, Elizabeth Dauncey, James J. Douglas, Alessandro Ruffoni, Daniele Leonori
Photoinduced decarboxylative azidation of cyclic amino acids
published pages: 1839-1842, ISSN: 1477-0520, DOI: 10.1039/c8ob02702a
Organic & Biomolecular Chemistry 17/7 2019-09-05
2018 Sara P. Morcillo, Elizabeth M. Dauncey, Ji Hye Kim, James J. Douglas, Nadeem S. Sheikh, Daniele Leonori
Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals
published pages: 12945-12949, ISSN: 1433-7851, DOI: 10.1002/anie.201807941
Angewandte Chemie International Edition 57/39 2019-09-05
2019 Alessandro Ruffoni, Fabio Juliá, Thomas D. Svejstrup, Alastair J. McMillan, James J. Douglas, Daniele Leonori
Practical and regioselective amination of arenes using alkyl amines
published pages: 426-433, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0254-5
Nature Chemistry 11/5 2019-09-05
2019 Lucrezia Angelini, Jacob Davies, Marco Simonetti, Laia Malet Sanz, Nadeem S. Sheikh, Daniele Leonori
Reaction of Nitrogen-Radicals with Organometallics Under Ni-Catalysis: N-Arylations and Amino-Functionalization Cascades
published pages: 5003-5007, ISSN: 1433-7851, DOI: 10.1002/anie.201900510
Angewandte Chemie International Edition 58/15 2019-09-05

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