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Novel Blueprints for the Visible-Light-Mediated Assembly of C–N Bonds via Nitrogen Radicals

Total Cost €


EC-Contrib. €






 NEBULAR project word cloud

Explore the words cloud of the NEBULAR project. It provides you a very rough idea of what is the project "NEBULAR" about.

centered    limited    visible    evolution    molecules    atoms    almost    invention    merge    modulate    organic    metal    daily    dual    transform    generating    strategic    class    modern    containing    mediated    compounds    entire    reactive    transformative    forming    despite    efficient    synthesis    life    transition    photoredox    biological    combine    bonds    explore    asymmetric    discovery    shapes    forged    basis    pharmaceuticals    multicomponent    implications    3d    food    ncrs    assembled    cohesive    harness    agrochemicals    intermediates    discover    strategies    energy    protocols    fundamental    sustainable    reactivity    innovative    agrochemical    harnessing    therapeutic    generation    group    ways    structural    selective    alone    preconceptions    transformations    chemistry    relevance    lives    tools    additives    quality    organocatalysis    reactions    radicals    construction    unprecedented    direct    inexpensive    form    materials    catalysis    light    catalytic    assembly    nitrogen    underpin    source   

Project "NEBULAR" data sheet

The following table provides information about the project.


Organization address
address: OXFORD ROAD
postcode: M13 9PL

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙494˙777 €
 EC max contribution 1˙494˙777 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF MANCHESTER UK (MANCHESTER) coordinator 1˙494˙777.00


 Project objective

Nitrogen-containing compounds underpin every aspect of our daily life as they form the structural basis of almost all pharmaceuticals, agrochemicals, food additives and materials. The invention of methods for the formation of bonds between C and N atoms is of strategic importance for the discovery and evolution of molecules with direct implications on the quality of our lives. Despite this fundamental relevance, forming C–N bonds is still a very challenging task. This proposal aims to deliver transformative advances for the development of new efficient and selective strategies for the synthesis of N-containing molecules by harnessing visible-light as inexpensive and sustainable source of energy. I aim to challenge preconceptions about the field of organic chemistry and to develop innovative methods to control, modulate and transform the reactivity of nitrogen-centered radicals (NCRs), an entire class of reactive intermediates for which there are only limited applications in modern organic chemistry. My research group has developed two novel visible-light-mediated ways of generating NCRs, and I aim to: (1) Harness and explore the unique features of visible-light-mediated transformations to provide novel multicomponent reactions of NCRs. (2) Establish NCRs as viable partners in asymmetric photoredox catalysis and use them for the easy construction of complex molecules with defined 3D shapes. (3) Merge the visible-light generation of NCRs with organocatalysis to enable novel dual catalytic asymmetric protocols. (4) Combine the NCRs with transition metal catalysis and discover unprecedented transformations that go beyond photoredox catalysis and transition metal catalysis alone. This cohesive and innovative approach will develop new tools essential for the assembly of complex molecules with biological, therapeutic and agrochemical properties. Overall this project will transform the way C–N bonds are forged and how N-containing molecules are assembled.


year authors and title journal last update
List of publications.
2019 David C. Marcote, Rosie Street-Jeakings, Elizabeth Dauncey, James J. Douglas, Alessandro Ruffoni, Daniele Leonori
Photoinduced decarboxylative azidation of cyclic amino acids
published pages: 1839-1842, ISSN: 1477-0520, DOI: 10.1039/c8ob02702a
Organic & Biomolecular Chemistry 17/7 2019-09-05
2018 Sara P. Morcillo, Elizabeth M. Dauncey, Ji Hye Kim, James J. Douglas, Nadeem S. Sheikh, Daniele Leonori
Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen Radicals
published pages: 12945-12949, ISSN: 1433-7851, DOI: 10.1002/anie.201807941
Angewandte Chemie International Edition 57/39 2019-09-05
2019 Alessandro Ruffoni, Fabio Juliá, Thomas D. Svejstrup, Alastair J. McMillan, James J. Douglas, Daniele Leonori
Practical and regioselective amination of arenes using alkyl amines
published pages: 426-433, ISSN: 1755-4330, DOI: 10.1038/s41557-019-0254-5
Nature Chemistry 11/5 2019-09-05
2019 Lucrezia Angelini, Jacob Davies, Marco Simonetti, Laia Malet Sanz, Nadeem S. Sheikh, Daniele Leonori
Reaction of Nitrogen-Radicals with Organometallics Under Ni-Catalysis: N-Arylations and Amino-Functionalization Cascades
published pages: 5003-5007, ISSN: 1433-7851, DOI: 10.1002/anie.201900510
Angewandte Chemie International Edition 58/15 2019-09-05

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