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HISENTS SIGNED

High level Integrated SEnsor for NanoToxicity Screening

Total Cost €

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EC-Contrib. €

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Partnership

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Project "HISENTS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF LEEDS 

Organization address
address: WOODHOUSE LANE
city: LEEDS
postcode: LS2 9JT
website: www.leeds.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 6˙332˙825 €
 EC max contribution 6˙332˙825 € (100%)
 Programme 1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies)
 Code Call H2020-NMP-2015-two-stage
 Funding Scheme /RIA
 Starting year 2016
 Duration (year-month-day) from 2016-04-01   to  2019-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF LEEDS UK (LEEDS) coordinator 1˙411˙205.00
2    FRAUNHOFER GESELLSCHAFT ZUR FOERDERUNG DER ANGEWANDTEN FORSCHUNG E.V. DE (MUNCHEN) participant 899˙990.00
3    UNIVERSITY COLLEGE CORK - NATIONAL UNIVERSITY OF IRELAND, CORK IE (Cork) participant 800˙960.00
4    TEL AVIV UNIVERSITY IL (TEL AVIV) participant 631˙875.00
5    SLOVENSKA TECHNICKA UNIVERZITA V BRATISLAVE SK (BRATISLAVA) participant 508˙745.00
6    Blueprint Product Design Ltd UK (Keighley) participant 500˙050.00
7    TECHNISCHE UNIVERSITAET WIEN AT (WIEN) participant 368˙750.00
8    FUNDACIO INSTITUT CATALA DE NANOCIENCIA I NANOTECNOLOGIA ES (BELLATERRA (BARCELONA)) participant 341˙250.00
9    BIOMEDICINSKE CENTRUM SLOVENSKEJ AKADEMIE VIED SK (BRATISLAVA) participant 300˙000.00
10    NORSK INSTITUTT FOR LUFTFORSKNING STIFTELSE NO (KJELLER) participant 300˙000.00
11    UNIVERSITAT DES SAARLANDES DE (SAARBRUCKEN) participant 270˙000.00
12    USTAV EXPERIMENTALNEJ ONKOLOGIE SLOVENSKEJ AKADEMIE VIED SK (BRATISLAVA) participant 0.00

Mappa

 Project objective

The HISENTS vision is to address the problem of the dearth of high-quality tools for nano-safety assessment by introducing an innovative multimodular high throughput screening (HTP) platform including a set of individual modules each representing a critical physiological function connected and integrated in a hierarchical vectorial manner by a microfluidic network. The increase of the capacity to perform nano-safety assessment will be realised by innovative instrumentation developments for HTP and high content analysis (HCA) approaches. Toxicogenomics on chip is also one embedded objective. Our interdisciplinary approach focuses on tools to maximise the read-across and to assess applicable endpoints for advanced risk assessment of nanomaterials (NM). The main goal is thus to establish individual chip-based microfluidic tools as devices for (nano)toxicity screening which can be combined as an on-line HTP platform. Seven different chip-based sensor elements will be developed and hierarchically combined via a flow system to characterise toxicity pathways of NM. The HISENTS platform allows the grouping and identifying of NM. Parallel to the screening, the pathway and interaction of NM in biological organisms will be simulated using the physiologically based pharmacokinetic (PBPK) model. Using the different sensor modules from the molecular to cell to organ level, HISENTS can input quantitative parameters into the PBPK model resulting in an effective pathway analysis for NM and other critical compounds. The developed platform is crucial for realistic nano-safety assessment and will also find extensive application in pharmaceutical screening due to the flexible modifications of the HTP platform. The specific objective is the development of a multimodular HTP platform as new a screening tool for enhancing the efficiency of hazard profiling. Currently, no such flexible, easy-to-use screening platform with flexibly combinable chip-based sensors is available on the market.

 Work performed, outcomes and results:  advancements report(s) 

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The information about "HISENTS" are provided by the European Opendata Portal: CORDIS opendata.

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