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STARSTEM SIGNED

NanoSTARS imaging for STEM cell therapy for arthritic joints

Total Cost €

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EC-Contrib. €

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Partnership

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 STARSTEM project word cloud

Explore the words cloud of the STARSTEM project. It provides you a very rough idea of what is the project "STARSTEM" about.

population    treatments    organs    regeneration    worldwide    nanostar    repair    efficacy    inability    deep    differential    individual    transplanted    safety    cartilage    arthritic    arthritis    mediated    tissue    registered    nanostars    engraftment    enhanced    prior    therapeutic    clinical    self    proposing    dual    detect    sensitive    gold    sensitivity    gaps    engraft    retention    global    algorithms    advantages    exploits    did    penetration    symptomatic    disease    monitoring    harness    prevalent    diagnose    photoacoustic    10    techniques    joints    restorative    finger    human    majority    time    designed    therapy    animal    optical    cell    conjugated    injured    imaging    mri    sound    conventional    cure    tracking    co    contrast    successful    small    movement    magnetic    cells    modal    humans    nanomaterial    unprecedented    osteoarthritis    site    opportunity    hurdles    proposes    depths    starstem    anatomical    functional    pa    provides    clinically    light    oa    animals    patients    million    nanoparticles    proof    stem    plasmonic    agent   

Project "STARSTEM" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://starstem.eu/
 Total cost 5˙933˙952 €
 EC max contribution 5˙933˙952 € (100%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙989˙565.00
2    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) participant 1˙014˙560.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 778˙101.00
4    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 599˙260.00
5    ITHERA MEDICAL GMBH DE (MUNCHEN) participant 535˙625.00
6    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 506˙840.00
7    ITHERA SCIENTIFIC GMBH DE (MUNCHEN) participant 260˙000.00
8    PINTAIL LTD IE (Blackrock) participant 250˙000.00
9    BIORIGEN SRL IT (GENOVA) participant 0.00

Map

 Project objective

STARSTEM proposes imaging of stem cell engraftment in arthritic joints of large animals at clinically relevant depths, using nanoparticles with novel optical properties which enable unprecedented penetration depth and sensitivity. Arthritis is the most prevalent disease worldwide, with osteoarthritis (OA) affecting around 10% of the global population and around 70 million patients in Europe. There is no effective cure for OA at present and the majority of the treatments are symptomatic and not restorative. Stem cell therapy provides a unique opportunity for the self-regeneration of injured cartilage. One of the major hurdles in stem cell mediated-therapy is the inability to diagnose successful engraftment in real time using conventional imaging techniques. STARSTEM will address the major technology gaps to enable imaging of human stem cells at clinically relevant depths. STARSTEM is proposing the use of novel dual plasmonic gold nanostars (nanostars)-enhanced multi-modal imaging to detect stem cell engraftment and tissue repair, and thus their activity and efficacy as a therapy. STARSTEM will harness the best properties of light and sound with a photoacoustic (PA) imaging system for large animal and human finger imaging as proof-of-concept which exploits the unique advantages of our nanomaterial for differential and deep-tissue imaging. Functional imaging using PA enables the real time monitoring of engraftment and the therapeutic process at the site of interest, while highly sensitive anatomical imaging using MRI (using nanostar conjugated with magnetic nanoparticles as contrast agent) enables tracking of the movement and retention in individual organs of the transplanted cells that did not engraft. Algorithms for co-registered PA-MRI imaging approach will enable monitoring of the therapeutic process with high sensitivity. The overall imaging approach is designed to address small to large animal testing for efficacy and safety prior to clinical testing on humans.

 Deliverables

List of deliverables.
Dissemination materials Websites, patent fillings, videos etc. 2020-01-16 16:31:56
Website Websites, patent fillings, videos etc. 2020-01-16 16:31:56

Take a look to the deliverables list in detail:  detailed list of STARSTEM deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
published pages: 121105, ISSN: 0003-6951, DOI: 10.1063/1.5110459
Applied Physics Letters 115/12 2020-01-16

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The information about "STARSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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