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NanoSTARS imaging for STEM cell therapy for arthritic joints

Total Cost €


EC-Contrib. €






 STARSTEM project word cloud

Explore the words cloud of the STARSTEM project. It provides you a very rough idea of what is the project "STARSTEM" about.

10    engraftment    enhanced    finger    hurdles    time    worldwide    cure    treatments    deep    detect    population    injured    joints    magnetic    imaging    functional    unprecedented    pa    animals    photoacoustic    clinical    clinically    tracking    arthritis    proposing    nanoparticles    humans    regeneration    nanostars    dual    self    penetration    cartilage    starstem    differential    optical    transplanted    mediated    sensitive    techniques    repair    safety    nanomaterial    symptomatic    proposes    advantages    disease    proof    depths    successful    light    retention    prior    opportunity    patients    cells    majority    did    individual    movement    engraft    gaps    diagnose    sound    plasmonic    gold    co    therapy    mri    oa    restorative    contrast    tissue    prevalent    million    small    inability    agent    stem    global    monitoring    algorithms    therapeutic    cell    nanostar    animal    designed    efficacy    arthritic    osteoarthritis    exploits    provides    conventional    site    harness    organs    registered    modal    anatomical    conjugated    human    sensitivity   

Project "STARSTEM" data sheet

The following table provides information about the project.


Organization address
city: Galway
postcode: H91

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website
 Total cost 5˙933˙952 €
 EC max contribution 5˙933˙952 € (100%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙989˙565.00
2    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) participant 1˙014˙560.00
5    ITHERA MEDICAL GMBH DE (MUNCHEN) participant 535˙625.00
6    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 506˙840.00
7    ITHERA SCIENTIFIC GMBH DE (MUNCHEN) participant 260˙000.00
8    PINTAIL LTD IE (Blackrock) participant 250˙000.00
9    BIORIGEN SRL IT (GENOVA) participant 0.00


 Project objective

STARSTEM proposes imaging of stem cell engraftment in arthritic joints of large animals at clinically relevant depths, using nanoparticles with novel optical properties which enable unprecedented penetration depth and sensitivity. Arthritis is the most prevalent disease worldwide, with osteoarthritis (OA) affecting around 10% of the global population and around 70 million patients in Europe. There is no effective cure for OA at present and the majority of the treatments are symptomatic and not restorative. Stem cell therapy provides a unique opportunity for the self-regeneration of injured cartilage. One of the major hurdles in stem cell mediated-therapy is the inability to diagnose successful engraftment in real time using conventional imaging techniques. STARSTEM will address the major technology gaps to enable imaging of human stem cells at clinically relevant depths. STARSTEM is proposing the use of novel dual plasmonic gold nanostars (nanostars)-enhanced multi-modal imaging to detect stem cell engraftment and tissue repair, and thus their activity and efficacy as a therapy. STARSTEM will harness the best properties of light and sound with a photoacoustic (PA) imaging system for large animal and human finger imaging as proof-of-concept which exploits the unique advantages of our nanomaterial for differential and deep-tissue imaging. Functional imaging using PA enables the real time monitoring of engraftment and the therapeutic process at the site of interest, while highly sensitive anatomical imaging using MRI (using nanostar conjugated with magnetic nanoparticles as contrast agent) enables tracking of the movement and retention in individual organs of the transplanted cells that did not engraft. Algorithms for co-registered PA-MRI imaging approach will enable monitoring of the therapeutic process with high sensitivity. The overall imaging approach is designed to address small to large animal testing for efficacy and safety prior to clinical testing on humans.


List of deliverables.
Dissemination materials Websites, patent fillings, videos etc. 2020-01-16 16:31:56
Website Websites, patent fillings, videos etc. 2020-01-16 16:31:56

Take a look to the deliverables list in detail:  detailed list of STARSTEM deliverables.


year authors and title journal last update
List of publications.
2019 Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
published pages: 121105, ISSN: 0003-6951, DOI: 10.1063/1.5110459
Applied Physics Letters 115/12 2020-01-16

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The information about "STARSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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NanoSTARS imaging for STEM cell therapy for arthritic joints

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