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STARSTEM SIGNED

NanoSTARS imaging for STEM cell therapy for arthritic joints

Total Cost €

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EC-Contrib. €

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Partnership

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 STARSTEM project word cloud

Explore the words cloud of the STARSTEM project. It provides you a very rough idea of what is the project "STARSTEM" about.

treatments    restorative    techniques    anatomical    human    cartilage    time    differential    clinically    agent    injured    therapeutic    nanostars    animal    pa    nanomaterial    engraftment    oa    exploits    gold    repair    osteoarthritis    penetration    stem    humans    proof    provides    proposes    organs    mri    therapy    arthritis    million    site    successful    diagnose    inability    small    contrast    transplanted    dual    tracking    proposing    depths    conventional    self    sound    modal    light    patients    prevalent    deep    conjugated    functional    hurdles    regeneration    individual    advantages    harness    detect    designed    joints    worldwide    sensitivity    tissue    arthritic    mediated    engraft    monitoring    retention    10    disease    majority    starstem    cells    unprecedented    registered    population    co    photoacoustic    imaging    cell    cure    plasmonic    finger    clinical    enhanced    efficacy    gaps    nanostar    symptomatic    nanoparticles    sensitive    safety    magnetic    optical    did    movement    global    animals    opportunity    algorithms    prior   

Project "STARSTEM" data sheet

The following table provides information about the project.

Coordinator
NATIONAL UNIVERSITY OF IRELAND GALWAY 

Organization address
address: UNIVERSITY ROAD
city: Galway
postcode: H91
website: www.nuigalway.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Project website http://starstem.eu/
 Total cost 5˙933˙952 €
 EC max contribution 5˙933˙952 € (100%)
 Programme 1. H2020-EU.2.1.2. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Nanotechnologies)
 Code Call H2020-NMBP-2017-two-stage
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    NATIONAL UNIVERSITY OF IRELAND GALWAY IE (Galway) coordinator 1˙989˙565.00
2    UNIVERSITA DEGLI STUDI DI GENOVA IT (GENOVA) participant 1˙014˙560.00
3    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 778˙101.00
4    TECHNISCHE UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 599˙260.00
5    ITHERA MEDICAL GMBH DE (MUNCHEN) participant 535˙625.00
6    FUNDACIO INSTITUT DE CIENCIES FOTONIQUES ES (Castelldefels) participant 506˙840.00
7    ITHERA SCIENTIFIC GMBH DE (MUNCHEN) participant 260˙000.00
8    PINTAIL LTD IE (Blackrock) participant 250˙000.00
9    BIORIGEN SRL IT (GENOVA) participant 0.00

Map

 Project objective

STARSTEM proposes imaging of stem cell engraftment in arthritic joints of large animals at clinically relevant depths, using nanoparticles with novel optical properties which enable unprecedented penetration depth and sensitivity. Arthritis is the most prevalent disease worldwide, with osteoarthritis (OA) affecting around 10% of the global population and around 70 million patients in Europe. There is no effective cure for OA at present and the majority of the treatments are symptomatic and not restorative. Stem cell therapy provides a unique opportunity for the self-regeneration of injured cartilage. One of the major hurdles in stem cell mediated-therapy is the inability to diagnose successful engraftment in real time using conventional imaging techniques. STARSTEM will address the major technology gaps to enable imaging of human stem cells at clinically relevant depths. STARSTEM is proposing the use of novel dual plasmonic gold nanostars (nanostars)-enhanced multi-modal imaging to detect stem cell engraftment and tissue repair, and thus their activity and efficacy as a therapy. STARSTEM will harness the best properties of light and sound with a photoacoustic (PA) imaging system for large animal and human finger imaging as proof-of-concept which exploits the unique advantages of our nanomaterial for differential and deep-tissue imaging. Functional imaging using PA enables the real time monitoring of engraftment and the therapeutic process at the site of interest, while highly sensitive anatomical imaging using MRI (using nanostar conjugated with magnetic nanoparticles as contrast agent) enables tracking of the movement and retention in individual organs of the transplanted cells that did not engraft. Algorithms for co-registered PA-MRI imaging approach will enable monitoring of the therapeutic process with high sensitivity. The overall imaging approach is designed to address small to large animal testing for efficacy and safety prior to clinical testing on humans.

 Deliverables

List of deliverables.
Dissemination materials Websites, patent fillings, videos etc. 2020-01-16 16:31:56
Website Websites, patent fillings, videos etc. 2020-01-16 16:31:56

Take a look to the deliverables list in detail:  detailed list of STARSTEM deliverables.

 Publications

year authors and title journal last update
List of publications.
2019 Sergey Alexandrov, Paul M. McNamara, Nandan Das, Yi Zhou, Gillian Lynch, Josh Hogan, Martin Leahy
Spatial frequency domain correlation mapping optical coherence tomography for nanoscale structural characterization
published pages: 121105, ISSN: 0003-6951, DOI: 10.1063/1.5110459
Applied Physics Letters 115/12 2020-01-16

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The information about "STARSTEM" are provided by the European Opendata Portal: CORDIS opendata.

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