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Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development

Total Cost €


EC-Contrib. €






 LinPro project word cloud

Explore the words cloud of the LinPro project. It provides you a very rough idea of what is the project "LinPro" about.

genetic    neural    conceptual    circuits    decipher    stem    cerebral    mechanistic    gliogenesis    fundamental    relative    organoid    mosaic    nearly    mammalian    definitive    situ    deterministic    unsolved    cellular    cells    degree    quantitative    mechanisms    neuroscience    insights    glia    producing    unparalleled    extensive    neurons    unknown    single    cell    logic    double    offers    neurogenesis    progression    progress    responsible    nature    rgp    astrocytes    proliferation    molecular    stochasticity    diversity    manipulate    madm    model    certain    obtain    ultimate    unprecedented    regarding    functional    extraordinary    lineage    fraction    neuronal    entity    signaling    genetically    resolution    radial    question    principles    pursuit    small    contribution    consists    neocortex    arises    dissect    framework    autonomous    cortical    sparse    scope    precipitate    behavior    efforts    progenitors    neuroepithelium    functionally    clones    rgps    intrinsic    multidisciplinary    human    nscs    markers    neocortical    questions    experimental    concomitantly    cortex    visualize   

Project "LinPro" data sheet

The following table provides information about the project.


Organization address
address: Am Campus 1
postcode: 3400

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙996˙030 €
 EC max contribution 1˙996˙030 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The cerebral cortex consists of an extraordinary number and great diversity of neurons. Yet, how the cortical entity, with all its functional neuronal circuits, arises from the neural stem cells (NSCs) in the developing neuroepithelium is a major unsolved question in Neuroscience. Radial glia progenitors (RGPs) are responsible for producing nearly all neocortical neurons and a certain fraction of cortical glia including astrocytes. Our recent efforts provide evidence for a high degree of non-stochasticity and thus deterministic nature of RGP behavior in the mammalian neocortex. However, the cellular and molecular mechanisms controlling RGP lineage progression through proliferation, neurogenesis and especially gliogenesis are unknown. In a pursuit to obtain definitive insights into these fundamental questions we assess RGP lineage progression at the unprecedented single cell resolution, using the unique genetic MADM (Mosaic Analysis with Double Markers) technology. MADM offers an unparalleled approach to visualize and concomitantly manipulate sparse clones and small subsets of genetically defined neurons. Within the scope of this project we will use multidisciplinary experimental approaches to establish a research program with the following major objectives: We will 1) Functionally dissect the relative contribution of cell-autonomous intrinsic signaling and cell-non-autonomous effects in RGP lineage progression; 2) Define the principles of lineage progression in human RGPs in situ using MADM technology in cerebral organoid system; 3) Decipher the logic of glia lineage progression in the neocortex. The ultimate goal of the proposed research is to establish a definitive quantitative framework and mechanistic model of lineage progression in cortical NSCs. As such, the proposed research shall precipitate into extensive conceptual progress regarding the fundamental cellular and molecular principles of cerebral cortex development.


year authors and title journal last update
List of publications.
2019 Nicole Amberg, Susanne Laukoter, Simon Hippenmeyer
Epigenetic cues modulating the generation of cell‐type diversity in the cerebral cortex
published pages: 12-26, ISSN: 0022-3042, DOI: 10.1111/jnc.14601
Journal of Neurochemistry 149/1 2020-03-24
2019 Noemi Picco, Simon Hippenmeyer, Julio Rodarte, Carmen Streicher, Zoltán Molnár, Philip K. Maini, Thomas E. Woolley
A mathematical insight into cell labelling experiments for clonal analysis
published pages: , ISSN: 0021-8782, DOI: 10.1111/joa.13001
Journal of Anatomy 2020-03-24
2019 Gonzalo Ortiz-Álvarez, Marie Daclin, Asm Shihavuddin, Pauline Lansade, Aurélien Fortoul, Marion Faucourt, Solène Clavreul, Maria-Eleni Lalioti, Stavros Taraviras, Simon Hippenmeyer, Jean Livet, Alice Meunier, Auguste Genovesio, Nathalie Spassky
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
published pages: 159-172.e7, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.051
Neuron 102/1 2020-03-24
2018 Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong K. Wong, Giovanni Diana, Eleni Serafeimidou, Marian Fernández-Otero, Carmen Streicher, Sebastian J. Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall, Oscar Marín
Heterogeneous progenitor cell behaviors underlie the assembly of neocortical cytoarchitecture
published pages: , ISSN: , DOI: 10.1101/494088
The Preprint Server for Biology 494088 2020-03-24
2019 L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fièvre, P. Oberst, G. Bartolini, I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
published pages: eaav2522, ISSN: 0036-8075, DOI: 10.1126/science.aav2522
Science 364/6440 2020-03-24

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The information about "LINPRO" are provided by the European Opendata Portal: CORDIS opendata.

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