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LinPro SIGNED

Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development

Total Cost €

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EC-Contrib. €

0

Partnership

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 LinPro project word cloud

Explore the words cloud of the LinPro project. It provides you a very rough idea of what is the project "LinPro" about.

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Project "LinPro" data sheet

The following table provides information about the project.

Coordinator
INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA 

Organization address
address: Am Campus 1
city: KLOSTERNEUBURG
postcode: 3400
website: www.ist.ac.at

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Austria [AT]
 Total cost 1˙996˙030 €
 EC max contribution 1˙996˙030 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-COG
 Funding Scheme ERC-COG
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2022-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA AT (KLOSTERNEUBURG) coordinator 1˙996˙030.00

Map

 Project objective

The cerebral cortex consists of an extraordinary number and great diversity of neurons. Yet, how the cortical entity, with all its functional neuronal circuits, arises from the neural stem cells (NSCs) in the developing neuroepithelium is a major unsolved question in Neuroscience. Radial glia progenitors (RGPs) are responsible for producing nearly all neocortical neurons and a certain fraction of cortical glia including astrocytes. Our recent efforts provide evidence for a high degree of non-stochasticity and thus deterministic nature of RGP behavior in the mammalian neocortex. However, the cellular and molecular mechanisms controlling RGP lineage progression through proliferation, neurogenesis and especially gliogenesis are unknown. In a pursuit to obtain definitive insights into these fundamental questions we assess RGP lineage progression at the unprecedented single cell resolution, using the unique genetic MADM (Mosaic Analysis with Double Markers) technology. MADM offers an unparalleled approach to visualize and concomitantly manipulate sparse clones and small subsets of genetically defined neurons. Within the scope of this project we will use multidisciplinary experimental approaches to establish a research program with the following major objectives: We will 1) Functionally dissect the relative contribution of cell-autonomous intrinsic signaling and cell-non-autonomous effects in RGP lineage progression; 2) Define the principles of lineage progression in human RGPs in situ using MADM technology in cerebral organoid system; 3) Decipher the logic of glia lineage progression in the neocortex. The ultimate goal of the proposed research is to establish a definitive quantitative framework and mechanistic model of lineage progression in cortical NSCs. As such, the proposed research shall precipitate into extensive conceptual progress regarding the fundamental cellular and molecular principles of cerebral cortex development.

 Publications

year authors and title journal last update
List of publications.
2019 Nicole Amberg, Susanne Laukoter, Simon Hippenmeyer
Epigenetic cues modulating the generation of cell‐type diversity in the cerebral cortex
published pages: 12-26, ISSN: 0022-3042, DOI: 10.1111/jnc.14601
Journal of Neurochemistry 149/1 2020-03-24
2019 Noemi Picco, Simon Hippenmeyer, Julio Rodarte, Carmen Streicher, Zoltán Molnár, Philip K. Maini, Thomas E. Woolley
A mathematical insight into cell labelling experiments for clonal analysis
published pages: , ISSN: 0021-8782, DOI: 10.1111/joa.13001
Journal of Anatomy 2020-03-24
2019 Gonzalo Ortiz-Álvarez, Marie Daclin, Asm Shihavuddin, Pauline Lansade, Aurélien Fortoul, Marion Faucourt, Solène Clavreul, Maria-Eleni Lalioti, Stavros Taraviras, Simon Hippenmeyer, Jean Livet, Alice Meunier, Auguste Genovesio, Nathalie Spassky
Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members
published pages: 159-172.e7, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.01.051
Neuron 102/1 2020-03-24
2018 Alfredo Llorca, Gabriele Ciceri, Robert Beattie, Fong K. Wong, Giovanni Diana, Eleni Serafeimidou, Marian Fernández-Otero, Carmen Streicher, Sebastian J. Arnold, Martin Meyer, Simon Hippenmeyer, Miguel Maravall, Oscar Marín
Heterogeneous progenitor cell behaviors underlie the assembly of neocortical cytoarchitecture
published pages: , ISSN: , DOI: 10.1101/494088
The Preprint Server for Biology 494088 2020-03-24
2019 L. Telley, G. Agirman, J. Prados, N. Amberg, S. Fièvre, P. Oberst, G. Bartolini, I. Vitali, C. Cadilhac, S. Hippenmeyer, L. Nguyen, A. Dayer, D. Jabaudon
Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex
published pages: eaav2522, ISSN: 0036-8075, DOI: 10.1126/science.aav2522
Science 364/6440 2020-03-24

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