Explore the words cloud of the New Chol project. It provides you a very rough idea of what is the project "New Chol" about.
The following table provides information about the project.
THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE
|Coordinator Country||United Kingdom [UK]|
|Total cost||2˙499˙111 €|
|EC max contribution||2˙499˙111 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2017-12-01 to 2022-11-30|
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|1||THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE||UK (CAMBRIDGE)||coordinator||2˙499˙111.00|
Cholangiopathies represent a diverse group of diseases affecting cholangiocytes which are the main cell type of the biliary tract. These disorders range from inherited (Cystic Fibrosis) and developmental (Alagille Syndrome, Biliary Atresia) to autoimmune (Primary Biliary Cirrhosis), idiopathic (Primary Sclerosing Cholangitis) and drug or toxin induced diseases. Cholangiopathies result in toxic bile accumulation in the liver inducing cell death and ultimately cirrhosis. They carry high morbidity and mortality, accounting for up to a third of chronic liver disorders. Whole liver transplantation remains the main treatment. However, organ transplant requires immunosuppression with significant side effects and an increasing number of patients die while on the transplant list due to the shortage of suitable donors. Finally, the absence of physiologically relevant in vitro systems to model and to study cholangiopathies prevents the development of new therapeutics while cell based therapy approach have been unexplored. Here, we propose to systematically address these challenges by developing a novel and innovative program of translational research focusing on cholangiopathies. We will first investigate the cellular and functional diversity of the biliary tract and its impact on disease by taking advantage of recent developments in single cell transcriptomic analyses. We will then use this basic knowledge to generate and to characterize for the first time a renewable source of cholangiocytes from human induced pluripotent stem cells and from biliary tissue. The resulting cells will be used to model cholangiopathies in vitro and to create a new platform for drug target identification. Finally, we will explore the potential for in vitro generated cholangiocytes to be used in regenerative medicine applications including cell based therapy. Overall this comprehensive program will uniquely path the way for the development of a whole range of new therapies for cholangiopathies.
|year||authors and title||journal||last update|
Charis-Patricia Segeritz, Sheikh Tamir Rashid, Miguel Cardoso de Brito, Maria Paola Serra, Adriana Ordonez, Carola Maria Morell, Joseph E. Kaserman, Pedro Madrigal, Nicholas R.F. Hannan, Laurent Gatto, Lu Tan, Andrew A. Wilson, Kathryn Lilley, Stefan J. Marciniak, Bibek Gooptu, David A. Lomas, Ludovic Vallier
hiPSC hepatocyte model demonstrates the role of unfolded protein response and inflammatory networks in Î±1-antitrypsin deficiency
published pages: 851-860, ISSN: 0168-8278, DOI: 10.1016/j.jhep.2018.05.028
|Journal of Hepatology 69/4||2020-01-28|
Loukia Yiangou, Rodrigo A. Grandy, Carola M. Morell, Rute A. Tomaz, Anna Osnato, Juned Kadiwala, Daniele Muraro, Jose Garcia-Bernardo, Shota Nakanoh, William G. Bernard, Daniel Ortmann, Davis J. McCarthy, Ingrid Simonic, Sanjay Sinha, Ludovic Vallier
Method to Synchronize Cell Cycle of Human Pluripotent Stem Cells without Affecting Their Fundamental Characteristics
published pages: 165-179, ISSN: 2213-6711, DOI: 10.1016/j.stemcr.2018.11.020
|Stem Cell Reports 12/1||2020-01-28|
Alexander W. Justin, Kourosh Saeb-Parsy, Athina E. Markaki, Ludovic Vallier, Fotios Sampaziotis
Advances in the generation of bioengineered bile ducts
published pages: 1532-1538, ISSN: 0925-4439, DOI: 10.1016/j.bbadis.2017.10.034
|Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 1864/4||2020-01-28|
Judith Kraiczy, Alexander D.B. Ross, Jessica L. Forbester, Gordon Dougan, Ludovic Vallier, Matthias Zilbauer
Genome-Wide EpigeneticÂ and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cellâ€“Derived Intestinal Epithelial Organoids
published pages: 285-288, ISSN: 2352-345X, DOI: 10.1016/j.jcmgh.2018.10.008
|Cellular and Molecular Gastroenterology and Hepatology 7/2||2020-01-28|
Stephanie M. Linker, Lara Urban, Stephen J. Clark, Mariya Chhatriwala, Shradha Amatya, Davis J. McCarthy, Ingo Ebersberger, Ludovic Vallier, Wolf Reik, Oliver Stegle, Marc Jan Bonder
Combined single-cell profiling of expression and DNA methylation reveals splicing regulation and heterogeneity
published pages: , ISSN: 1474-760X, DOI: 10.1186/s13059-019-1644-0
|Genome Biology 20/1||2020-01-28|
Alessandro Bertero, Stephanie Brown, Pedro Madrigal, Anna Osnato, Daniel Ortmann, Loukia Yiangou, Juned Kadiwala, Nina C. Hubner, Igor Ruiz de los Mozos, Christoph SadÃ©e, An-Sofie Lenaerts, Shota Nakanoh, Rodrigo Grandy, Edward Farnell, Jernej Ule, Hendrik G. Stunnenberg, Sasha Mendjan, Ludovic Vallier
The SMAD2/3 interactome reveals that TGFÎ² controls m6A mRNA methylation in pluripotency
published pages: 256-259, ISSN: 0028-0836, DOI: 10.1038/nature25784
AngÃ©lique Fourrier, FrÃ©dÃ©ric Delbos, SÃ©verine Menoret, Camille Collet, Linh Trinh Thi Thuy, Anne Myara, FranÃ§ois Petit, Laia Tolosa, Sophie Laplanche, MarÃa JosÃ© GÃ³mezâ€LechÃ³n, Philippe Labrune, Ignacio Anegon, Ludovic Vallier, Delphine Garnier, Tuan Huy Nguyen
Regenerative cell therapy for the treatment of hyperbilirubinemic Gunn rats with fresh and frozen human induced pluripotent stem cellsâ€derived hepatic stem cells
published pages: , ISSN: 0908-665X, DOI: 10.1111/xen.12544
Loukia Yiangou, Alexander D.B. Ross, Kim Jee Goh, Ludovic Vallier
Human Pluripotent Stem Cell-Derived Endoderm for Modeling Development and Clinical Applications
published pages: 485-499, ISSN: 1934-5909, DOI: 10.1016/j.stem.2018.03.016
|Cell Stem Cell 22/4||2020-01-28|
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