NANOCARGO SIGNED
Photo/magnetic stimulated nanocargos for superior cancer treatments
Total Cost €
0EC-Contrib. €
0Partnership
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0NANOCARGO project word cloud
Explore the words cloud of the NANOCARGO project. It provides you a very rough idea of what is the project "NANOCARGO" about.
Project "NANOCARGO" data sheet
The following table provides information about the project.
| Coordinator |
POLITECHNIKA WROCLAWSKA
Organization address contact info |
| Coordinator Country | Poland [PL] |
| Total cost | 146˙462 € |
| EC max contribution | 146˙462 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2016 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2018 |
| Duration (year-month-day) | from 2018-10-01 to 2020-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | POLITECHNIKA WROCLAWSKA | PL (WROCLAW) | coordinator | 146˙462.00 |
Map
Project objective
Breast cancer (BC) accounts for 28 % of the total cancer cases in the European Union (EU) and is the leading cause of cancer-related mortality of European women. The stratification of individual BC sub-types for corresponding therapy modalities is poor. Therapy outcomes in several BC sub-types are unsatisfactory. Its diagnosis is marred by high proportion of false positives and the economic burden to healthcare systems is very high. To overcome this NANOCARGO will develop a simultaneous diagnosis and therapy (theranostics) approach based on a multimodal nanocomposite termed as nanocargos. The battle against cancer is much more effectively fought if it is aided by early detection and, potentially concurrent, efficient treatment. NANOCARGO, introduces a new paradigm that theranostics can be made far more effective if a multimodal action can be integrated by adding a plasmonic shell to a magnetic nanoparticle core. The plasmonic shell can be functionalized with the chemotherapeutic drugs and aptamars. Magnetic@gold and magnetic@silver type core/shell nanocargos can be conjugated with anticancer aptamer. These nanocargos can be stimulated by simultaneous application of magnetic hyperthermia and photonic therapy. Cellular delivery can benefit from photoporation. Anticancer therapy can thus be made much more effective through the multimodal actions of these nanocargos exposed to endo-luminal, minimally invasive optical stimulation and extra-corporeal magnetic resonance imaging based excitation. Such a combined will maximise the delivery of these nanocargos into tumor cells. The magnetic core is advantageous for a controlled delivery of aptamer through an externally applied magnetic field. Gold and silver shell will support aptamer attachment. X-ray computed Tomography (CT) imaging contrast of absorbing tumors will be better due to higher X-ray absorption of gold and silver.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Nanasaheb D. Thorat, Joanna Bauer, Syed A.M. Tofail, Victoria Gascón Pérez, Raghvendra A. Bohara, Hemraj M. Yadav Silica nano supra-assembly for the targeted delivery of therapeutic cargo to overcome chemoresistance in cancer published pages: 110571, ISSN: 0927-7765, DOI: 10.1016/j.colsurfb.2019.110571 |
Colloids and Surfaces B: Biointerfaces 185 | 2020-02-27 |
| 2019 |
Nanasaheb D. Thorat, Syed A. M. Tofail, Brigitte von Rechenberg, Helen Townley, Grace Brennan, Christophe Silien, Hemraj M. Yadav, Thomas Steffen, Joanna Bauer Physically stimulated nanotheranostics for next generation cancer therapy: Focus on magnetic and light stimulations published pages: 41306, ISSN: 1931-9401, DOI: 10.1063/1.5049467 |
Applied Physics Reviews 6/4 | 2020-02-27 |
| 2019 |
Nanasaheb D. Thorat, Helen Townely, Grace Brennan, Abdul K. Parchur, Christophe Silien, Joanna Bauer, Syed A.M. Tofail Progress in Remotely Triggered Hybrid Nanostructures for Next-Generation Brain Cancer Theranostics published pages: 2669-2687, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.8b01173 |
ACS Biomaterials Science & Engineering 5/6 | 2020-02-27 |
| 2019 |
N.D. Thorat, C. Silien, S.A.M. Tofail, J. Bauer Smart hybrid nanostructures for cancer treatment published pages: 77, ISSN: , DOI: |
Scanning Probe Microscopy. Russia-China Workshop on Dielectric and Ferroelectric Materials.—Ekaterinburg, 2019 2019 | 2020-02-27 |
| 2018 |
Nanasaheb D. Thorat, Joanna Bauer MRI guided Magneto-Chemotherapy with high magnetic moment nanoparticles for cancer theranostics published pages: , ISSN: 2543-6724, DOI: |
Letters in Oncology Science vol. 15 app. 1 | 2020-02-27 |
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