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CONVINCE SIGNED

The Comparison of High-Dose Heamodiafiltration (HDF) versus Haemodialyse

Total Cost €

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EC-Contrib. €

0

Partnership

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 CONVINCE project word cloud

Explore the words cloud of the CONVINCE project. It provides you a very rough idea of what is the project "CONVINCE" about.

unmet    mortality    treatment    rates    dose    dialysis    paper    superiority    hospitalisation    accepted    severe    utility    alternative    publish    answer    diseases    regenerative    quality    clinical    progression    medicine    accumulated    ranks    decade    normal    infections    life    versus    stage    transplantation    replacement    gives    waste    regulatory    prospective    improvement    vast    therapy    medical    everyday    intervention    burden    communicable    fatal    standard    below    prevent    mark    10    question    removes    randomized    haemodialysis    idea    lacking    experimental    function    kidney    care    trial    urgently    money    patients    definite    risks    land    became    endpoints    patient    consequence    majority    small    stable    supports    strategies    cardiovascular    effecticvely    effort    haemodialfiltration    end    haemodiafiltration    conventional    society    hemodialysis    chronic    proof    annual    guideline    put    substantial    disease    15   

Project "CONVINCE" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAIR MEDISCH CENTRUM UTRECHT 

Organization address
address: HEIDELBERGLAAN 100
city: UTRECHT
postcode: 3584 CX
website: www.umcutrecht.nl

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Netherlands [NL]
 Project website http://www.convincetrial.eu
 Total cost 6˙865˙425 €
 EC max contribution 6˙440˙488 € (94%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SC1-2017-Two-Stage-RTD
 Funding Scheme RIA
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAIR MEDISCH CENTRUM UTRECHT NL (UTRECHT) coordinator 573˙062.00
2    JULIUS CLINICAL RESEARCH BV NL (ZEIST) participant 2˙256˙001.00
3    FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH DE (BAD HOMBURG) participant 850˙675.00
4    DIAVERUM SWEDEN AB SE (LUND) participant 701˙550.00
5    CHARITE - UNIVERSITAETSMEDIZIN BERLIN DE (BERLIN) participant 555˙127.00
6    B.Braun Avitum AG DE (MELSUNGEN) participant 510˙537.00
7    ROYAL FREE LONDON NHS FOUNDATION TRUST UK (LONDON) participant 413˙593.00
8    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) participant 361˙190.00
9    UNIVERSITY COLLEGE LONDON UK (LONDON) participant 209˙063.00
10    UNIVERSITA DEGLI STUDI DI BARI ALDO MORO IT (BARI) participant 9˙687.00

Map

 Project objective

End stage kidney disease ranks among the most severe chronic non-communicable diseases with an unmet medical need, given the high (between 10 and 15%) and stable annual mortality rates. Kidney replacement therapy is necessary when kidney function is below 10% of the normal value. Much effort is put into developing strategies to prevent chronic kidney disease progression. Regenerative medicine still is in the experimental phase and kidney transplantation is only available for a small number of patients. Indeed, the everyday reality is the growing number of dialysis patients. Haemodialysis treatment is the current standard of care for the vast majority of patients with end stage kidney disease. It is a substantial burden to the patient and for society. Haemodialysis treatment is associated with high risks for fatal and non-fatal cardiovascular disease, for infections, hospitalisation and low quality of life. Improvement in the currently available standard is urgently needed.

Over the past decade an alternative for haemodialysis became available, i.e. haemodiafiltration. Both are accepted by regulatory authorities. Haemodiafiltration removes waste products that are accumulated due to kidney failure, more effecticvely than standard hemodialysis. Present evidence supports the idea of superiority of haemodialfiltration compared to standard haemodialysis. However, definite proof is lacking and as a consequence haemodiafiltration is not yet widely applied.

This consortium aims to determine the best possible dialysis treatment by comparing the conventional guideline based haemodialysis treatment versus high-dose haemodiafiltration by carrying out a prospective randomized controlled clinical trial addressing clinical endpoints, quality of life and a cost-utility analysis. The study will deliver an answer on the question which intervention gives the best value for money. Therefore, it will be considered a “land mark” study, allowing to publish an “end of discussion” paper

 Deliverables

List of deliverables.
Project plan with general description of RCT, also including inclusion and exclusion criteria Documents, reports 2020-04-17 18:13:36
Project logo and website Websites, patent fillings, videos etc. 2020-04-07 22:44:45
Rationale and study paper Documents, reports 2020-04-07 22:44:45

Take a look to the deliverables list in detail:  detailed list of CONVINCE deliverables.

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The information about "CONVINCE" are provided by the European Opendata Portal: CORDIS opendata.

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