Opendata, web and dolomites

MicroBar SIGNED

Microsatellite Barcoding: reconstructing the family tree of hematopoietic cells

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "MicroBar" data sheet

The following table provides information about the project.

Coordinator
INSTITUT CURIE 

Organization address
address: rue d'Ulm 26
city: PARIS
postcode: 75231
website: www.curie.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙500˙000 €
 EC max contribution 1˙500˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2023-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INSTITUT CURIE FR (PARIS) coordinator 1˙500˙000.00

Map

 Project objective

While murine hematopoiesis has been considered as resolved science, recent results using barcoding, which allows the tracing of single cells in vivo, clearly show that the topology of the murine hematopoietic tree needs revisions. In parallel, human hematopoiesis has been overlooked and is widely considered as following the same tree as in mice. To leverage our understanding of normal human hematopoiesis, tools for barcoding in humans are urgently needed. This research program seeks to meet this need by taking advantage of recent developments in next generation sequencing to provide an improved barcoding method for in vivo use in human. Our microsatellite barcoding method exploits the fact that microsatellites in various loci undergo length changes during cell division, to create a natural barcode for each cell, and reconstruct the overall differentiation tree using a phylogenetic algorithm. Our technique, which is highly detailed with respect to current versions of microsatellite barcoding, provides high dimensional characterization of the cells and will allow the inference of important properties such as new phenotypic markers and key molecular regulators. Therefore, we will provide insights into both cell lineage and the molecular mechanisms involved in differentiation. With this method, we will provide the first in vivo description of the human hematopoietic tree and identify new progenitors and key molecular factors involved in human hematopoiesis. This knowledge will allow us to test whether cells with different origins have different functions, a key question in immunology in particular during infection and inflammation, and it will help design ways of therapeutically manipulating the hematopoietic system. More generally it will impact our understanding of stem cell differentiation for which hematopoiesis is used as an exemplar.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MICROBAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MICROBAR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

PrISMoID (2019)

Photonic Structural Materials with Controlled Disorder

Read More  

Life-Inspired (2019)

Life-inspired complex molecular systems controlled by enzymatic reaction networks

Read More  

NeuroMag (2019)

The Neurological Basis of the Magnetic Sense

Read More