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CHIPS SIGNED

Effects of Prenatal Exposure to Acrylamide on Health: Prospective Biomarker-Based Studies

Total Cost €

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EC-Contrib. €

0

Partnership

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 CHIPS project word cloud

Explore the words cloud of the CHIPS project. It provides you a very rough idea of what is the project "CHIPS" about.

disorders    humans    perspectives    crosses    protection    toxicants    diseases    forming    beverages    offspring    leads    toxicity    mostly    showing    strategies    prospective    cohort    acrylamide    toxic    hemoglobin    obesity    pregnant    time    follow    fertility    neurological    entailing    exposures    later    risk    biomarker    gaps    relied    2002    limited    cord    alone    authored    human    diabetes    characterization    function    measuring    questionnaires    life    adults    misclassification    epidemiological    degree    placenta    animals    fetal    adulthood    blood    critically    worldwide    urgently    metabolic    restriction    heritable    neurotoxic    prenatal    chips    adduct    raised    outcomes    discovery    causes    food    potentially    developmental    exposure    background    cancer    women    adducts    chemical    diet    young    first    health    never    tumors    mutations    cognition    impaired    foods    disturbed    innovative    formed    children    reproductive    combination   

Project "CHIPS" data sheet

The following table provides information about the project.

Coordinator
KOBENHAVNS UNIVERSITET 

Organization address
address: NORREGADE 10
city: KOBENHAVN
postcode: 1165
website: www.ku.dk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Denmark [DK]
 Total cost 1˙499˙531 €
 EC max contribution 1˙499˙531 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2023-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KOBENHAVNS UNIVERSITET DK (KOBENHAVN) coordinator 1˙113˙525.00
2    STOCKHOLMS UNIVERSITET SE (STOCKHOLM) participant 386˙005.00

Map

 Project objective

Background: Acrylamide is a chemical formed in many commonly consumed foods and beverages. It is neurotoxic, crosses the placenta and has been associated with restriction of fetal growth in humans. In animals, acrylamide causes heritable mutations, tumors, developmental toxicity, reduced fertility and impaired growth. Therefore, the discovery of acrylamide in food in 2002 raised concern about human health effects worldwide. Still, epidemiological studies are limited and effects on health of prenatal exposure have never been evaluated.

Research gaps: Epidemiological studies have mostly addressed exposure during adulthood, focused on cancer risk in adults, and relied on questionnaires entailing a high degree of exposure misclassification. Biomarker studies on prenatal exposure to acrylamide from diet are critically needed to improve exposure assessment and to determine whether acrylamide leads to major diseases later in life. Own results: I have first authored a prospective European study showing that prenatal exposure to acrylamide, estimated by measuring hemoglobin adducts in cord blood, was associated with fetal growth restriction, for the first time. Objectives: To determine the effects of prenatal exposure to acrylamide alone and in combination with other potentially toxic adduct-forming exposures on the health of children and young adults.

Methods: Both well-established and innovative biomarker methods will be used for characterization of prenatal exposure to acrylamide and related toxicants in blood from pregnant women and their offspring in prospective cohort studies with long-term follow-up. Risk of neurological disorders, impaired cognition, disturbed reproductive function and metabolic outcomes such as obesity and diabetes will be evaluated. Perspectives: CHIPS project will provide a better understanding of the impact of prenatal exposure to acrylamide from diet on human health urgently needed for targeted strategies for the protection of the health.

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The information about "CHIPS" are provided by the European Opendata Portal: CORDIS opendata.

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