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PyraSig SIGNED

Pyrazine Signalling in Commensal and Pathogenic Bacteria

Total Cost €

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EC-Contrib. €

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Partnership

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Project "PyraSig" data sheet

The following table provides information about the project.

Coordinator
FRIEDRICH-SCHILLER-UNIVERSITAT JENA 

Organization address
address: FURSTENGRABEN 1
city: JENA
postcode: 7743
website: www.uni-jena.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙499˙250 €
 EC max contribution 1˙499˙250 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-01-01   to  2022-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    FRIEDRICH-SCHILLER-UNIVERSITAT JENA DE (JENA) coordinator 1˙330˙157.00
2    LUDWIG-MAXIMILIANS-UNIVERSITAET MUENCHEN DE (MUENCHEN) participant 169˙092.00

Map

 Project objective

Quorum sensing (QS) is a bacterial cell–cell communication process involving the production, release, and detection of extracellular signal molecules called autoinducers. QS is key to all microbiology as it enables otherwise solitary bacteria to coordinate complex cooperative tasks such as biofilm formation and pathogenesis. Consequently, targeting QS is a promising new concept for antimicrobial therapy. However, for this concept to become reality, we must first identify QS systems in pathogenic bacteria, discover the relevant autoinducers and study the underlying regulatory principles. I recently identified a new QS pathway in Vibrio cholerae, the causative agent of cholera disease. The autoinducer of the system is DPO (3,5-dimethylpyrazin-2-ol), a new molecule to biology and the first pyrazine involved in QS. DPO production is widespread among microbes including pathogenic and commensal bacteria. V. cholerae synthesizes DPO from host mucins and our preliminary data show that DPO controls collective phenotypes, such as biofilm formation and toxin production in this major human pathogen. I therefore hypothesize that DPO connects virulence, QS and communication with the host microbiota in V. cholerae and related bacteria. The overarching goal of this project is to understand the roles of DPO in host-microbe interaction and collective behaviours. To this end, we will pursue three key research goals. First, we will study the molecular parameters underlying DPO-signalling and probe the global effects of DPO on gene expression. Second, we will focus on the role of DPO in virulence of V. cholerae and other pathogens. Third, we will probe the effect of DPO on microbial behaviours, such as swarming and biofilm formation. This combined work will provide a comprehensive model for DPO-signalling in bacteria, which will not only advance the fundamental understanding of QS-based communication strategies, but might also provide the framework for QS-inspired anti-infectives.

 Publications

year authors and title journal last update
List of publications.
2019 Roman Herzog1, Nikolai Peschek1,2, Kathrin S. Fr ¨ ohlich 1, Kilian Schumacher1 and Kai Papenfort
Three autoinducer molecules act in concert to control virulence gene expression in Vibrio cholerae
published pages: 3171–3183, ISSN: 1362-4962, DOI: 10.5281/zenodo.2661401
Nucleic Acids Research 1 2020-01-16
2018 Altuvia S1, Storz G2, Papenfort K3.
Cross-Regulation between Bacteria and Phages at a Posttranscriptional Level.
published pages: online, ISSN: 2165-0497, DOI: 10.5281/zenodo.3228787
Microbiol Spectr. 1 2020-01-16

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