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The N-IF mouse – a new and unique fibrosis model for preclinical efficacy studies

Total Cost €


EC-Contrib. €






 N-IF project word cloud

Explore the words cloud of the N-IF project. It provides you a very rough idea of what is the project "N-IF" about.

feasibility    model    industry    commercializing    labour    primary    chronic    shorten    lack    pipeline    experiment    preclinical    consuming    market    translate    pathology    induce    experimental    mouse    fibrosis    100    minimize    pharmaceutical    humans    resemble    swedish    disease    bio    animals    doors    protocols    mice    robustness    prepare    drug    ultimate    preceded    time    tests    clients    population    health    inflammatory    reductions    human    company    founded    fibrotic    models    huge    develops    prevalence    therapies    opening    inficure    animal    world    reproducibility    eliminates    acquired    validation    hampered    diseases    efficient    anti    date    nash    progression    enlarging    efficacy    pulmonary    good    spontaneously    segments    decrease    renal    technically    conduct    drugs    demanded    exhibits    50    2015    intensive    inflammation    weeks    liver    validated    proprietary    life    science    course    despite    25   

Project "N-IF" data sheet

The following table provides information about the project.


Organization address
address: TVISTEVAGEN 48C
city: UMEA
postcode: 907 36
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Sweden [SE]
 Project website
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.2.1.4. (INDUSTRIAL LEADERSHIP - Leadership in enabling and industrial technologies – Biotechnology)
2. H2020-EU.2.3.1. (Mainstreaming SME support, especially through a dedicated instrument)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2017
 Duration (year-month-day) from 2017-12-01   to  2018-05-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    INFICURE BIO AKTIEBOLAG SE (UMEA) coordinator 50˙000.00


 Project objective

InfiCure Bio is a Swedish Life Science company that was founded in 2015 with the primary objective of developing and commercializing a proprietary model for preclinical efficacy testing of anti-inflammatory and anti-fibrotic drugs. Our key product, the N-IF mouse, is a unique animal model that spontaneously develops fibrosis which is preceded by chronic inflammation and exhibits the same course of fibrotic disease progression as in humans, a unique feature that has been an ultimate need demanded by the pharmaceutical industry for many years.

There are no efficient therapies aimed against fibrotic diseases despite the high prevalence among the world population and the huge impact on human health. To date, drug development has been hampered due to the lack of good and reliable preclinical models that better resemble human fibrotic disease conditions. The N-IF mouse eliminates the problems of currently available animal models that are time-consuming, labour-intensive to induce fibrosis and have a low reproducibility. Its unique features will allow to shorten test protocols by 4-8 weeks, increase robustness of tests due to its 100% reproducibility and minimize the number of experimental animals needed. Reductions in experiment time and in mice numbers directly translate into a 25 - 50% decrease in the overall costs of preclinical testing of anti-fibrotic drugs. We have already technically validated the N-IF mouse as a model for liver fibrosis and have acquired two clients. The objective of the Phase 1 project is to conduct a feasibility study and prepare for further validation studies of the mouse model in order to establish the pathology of NASH, renal and pulmonary fibrosis that will be conducted as part of Phase 2, enlarging our pipeline models for fibrotic diseases and opening doors to new segments of the fibrotic diseases market.

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The information about "N-IF" are provided by the European Opendata Portal: CORDIS opendata.

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