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MuBoEx SIGNED

Mushroom Body Expansion in Heliconius butterflies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MuBoEx project word cloud

Explore the words cloud of the MuBoEx project. It provides you a very rough idea of what is the project "MuBoEx" about.

mb    questions    times    enigmatic    understand    appropriate    adaptive    function    basis    neuroscience    functional    differences    origins    synthesis    constraints    insects    lepidoptera    combine    determined    connections    region    insect    volume    cohesive    plan    central    variation    neuron    profound    trigger    butterflies    integration    neurons    evolutionary    neuroanatomical    proximate    fundamental    genera    brain    structures    behavioural    neural    developmental    connectivity    sensory    model    memories    genetic    causes    closely    expansion    asking    nature    volumetric    cues    species    proliferation    integrating    novelty    varies    bodies    mbs    bases    extensively    highest    environment    relate    larger    ask    plays    evolution    mechanisms    extract    regions    ultimate    integrate    mushroom    morphology    genomic    shape    storing    functions    time    ground    heliconius    size    conserved    density    share    encompassing    structure   

Project "MuBoEx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙940 €
 EC max contribution 1˙499˙940 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 1˙159˙470.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 340˙469.00

Map

 Project objective

The brain plays a central role in the production of adaptive behaviour. It must extract and integrate the most relevant sensory cues from the environment, and combine this information with memories of past experience to trigger appropriate behavioural responses. To fully understand the origins of behavioural novelty we need a detailed understanding of how behavioural differences are generated, both across evolutionary time and during development. This requires the integration of behavioural and neuroanatomical variation, and their genomic and developmental bases.

Mushroom bodies (MBs) are the most enigmatic structures in the insect brain. They have ‘higher order’ functions, integrating sensory information and storing memories of past experience. MBs share a conserved ground plan, but their size and structure varies extensively across species. MB morphology is determined by the number of MB neurons, and the nature and extent of connections they make with other brain regions. As such, they provide a model for asking fundamental questions about how selection, development and functional constraints shape brain evolution.

This project will establish a new study system in evolutionary neuroscience, Heliconius butterflies. MB volume in Heliconius is among the highest across insects, 3-4 times larger than typical for Lepidoptera, including closely related genera. The proposal represents a synthesis of four key objectives that will provide a cohesive understanding of MB expansion in Heliconius, encompassing both proximate and ultimate causes. Specifically, I will ask: i) How does MB expansion enhance behavioural function? ii) How do volumetric changes relate to differences in neuron number, density and connectivity? iii) What developmental mechanisms control region specific changes in neural proliferation? And iv) what is the genetic basis of MB expansion? Addressing these questions will provide profound advances in our understanding of brain evolution.

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The information about "MUBOEX" are provided by the European Opendata Portal: CORDIS opendata.

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