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MuBoEx SIGNED

Mushroom Body Expansion in Heliconius butterflies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MuBoEx project word cloud

Explore the words cloud of the MuBoEx project. It provides you a very rough idea of what is the project "MuBoEx" about.

novelty    evolution    bases    neuron    appropriate    morphology    plan    region    genera    heliconius    extract    proliferation    neurons    model    genomic    functions    relate    trigger    causes    extensively    cues    environment    mechanisms    butterflies    density    adaptive    lepidoptera    highest    sensory    ultimate    plays    fundamental    time    developmental    brain    varies    neuroscience    larger    variation    share    functional    encompassing    mb    cohesive    constraints    enigmatic    neuroanatomical    integrating    ask    integrate    memories    nature    bodies    questions    behavioural    size    basis    connectivity    mbs    volume    shape    determined    ground    insect    asking    volumetric    understand    closely    conserved    expansion    structure    synthesis    evolutionary    structures    connections    insects    differences    neural    profound    proximate    central    integration    mushroom    genetic    combine    species    function    regions    storing    times    origins   

Project "MuBoEx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙940 €
 EC max contribution 1˙499˙940 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 1˙159˙470.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 340˙469.00

Map

 Project objective

The brain plays a central role in the production of adaptive behaviour. It must extract and integrate the most relevant sensory cues from the environment, and combine this information with memories of past experience to trigger appropriate behavioural responses. To fully understand the origins of behavioural novelty we need a detailed understanding of how behavioural differences are generated, both across evolutionary time and during development. This requires the integration of behavioural and neuroanatomical variation, and their genomic and developmental bases.

Mushroom bodies (MBs) are the most enigmatic structures in the insect brain. They have ‘higher order’ functions, integrating sensory information and storing memories of past experience. MBs share a conserved ground plan, but their size and structure varies extensively across species. MB morphology is determined by the number of MB neurons, and the nature and extent of connections they make with other brain regions. As such, they provide a model for asking fundamental questions about how selection, development and functional constraints shape brain evolution.

This project will establish a new study system in evolutionary neuroscience, Heliconius butterflies. MB volume in Heliconius is among the highest across insects, 3-4 times larger than typical for Lepidoptera, including closely related genera. The proposal represents a synthesis of four key objectives that will provide a cohesive understanding of MB expansion in Heliconius, encompassing both proximate and ultimate causes. Specifically, I will ask: i) How does MB expansion enhance behavioural function? ii) How do volumetric changes relate to differences in neuron number, density and connectivity? iii) What developmental mechanisms control region specific changes in neural proliferation? And iv) what is the genetic basis of MB expansion? Addressing these questions will provide profound advances in our understanding of brain evolution.

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The information about "MUBOEX" are provided by the European Opendata Portal: CORDIS opendata.

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