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MuBoEx SIGNED

Mushroom Body Expansion in Heliconius butterflies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MuBoEx project word cloud

Explore the words cloud of the MuBoEx project. It provides you a very rough idea of what is the project "MuBoEx" about.

ground    times    genera    differences    sensory    extract    developmental    species    morphology    plan    mushroom    varies    asking    genomic    origins    synthesis    butterflies    neuron    adaptive    memories    storing    brain    connectivity    encompassing    heliconius    model    constraints    functions    regions    evolution    shape    structures    enigmatic    functional    highest    neural    relate    conserved    function    basis    central    neuroscience    expansion    mbs    novelty    mechanisms    ask    genetic    insect    volumetric    behavioural    size    lepidoptera    bodies    trigger    time    insects    connections    environment    volume    determined    mb    plays    understand    causes    fundamental    extensively    profound    combine    nature    ultimate    questions    closely    proliferation    integrate    density    region    proximate    cohesive    appropriate    integration    variation    neurons    neuroanatomical    evolutionary    larger    bases    share    structure    integrating    cues   

Project "MuBoEx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙940 €
 EC max contribution 1˙499˙940 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 1˙159˙470.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 340˙469.00

Map

 Project objective

The brain plays a central role in the production of adaptive behaviour. It must extract and integrate the most relevant sensory cues from the environment, and combine this information with memories of past experience to trigger appropriate behavioural responses. To fully understand the origins of behavioural novelty we need a detailed understanding of how behavioural differences are generated, both across evolutionary time and during development. This requires the integration of behavioural and neuroanatomical variation, and their genomic and developmental bases.

Mushroom bodies (MBs) are the most enigmatic structures in the insect brain. They have ‘higher order’ functions, integrating sensory information and storing memories of past experience. MBs share a conserved ground plan, but their size and structure varies extensively across species. MB morphology is determined by the number of MB neurons, and the nature and extent of connections they make with other brain regions. As such, they provide a model for asking fundamental questions about how selection, development and functional constraints shape brain evolution.

This project will establish a new study system in evolutionary neuroscience, Heliconius butterflies. MB volume in Heliconius is among the highest across insects, 3-4 times larger than typical for Lepidoptera, including closely related genera. The proposal represents a synthesis of four key objectives that will provide a cohesive understanding of MB expansion in Heliconius, encompassing both proximate and ultimate causes. Specifically, I will ask: i) How does MB expansion enhance behavioural function? ii) How do volumetric changes relate to differences in neuron number, density and connectivity? iii) What developmental mechanisms control region specific changes in neural proliferation? And iv) what is the genetic basis of MB expansion? Addressing these questions will provide profound advances in our understanding of brain evolution.

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The information about "MUBOEX" are provided by the European Opendata Portal: CORDIS opendata.

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