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MuBoEx SIGNED

Mushroom Body Expansion in Heliconius butterflies

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 MuBoEx project word cloud

Explore the words cloud of the MuBoEx project. It provides you a very rough idea of what is the project "MuBoEx" about.

questions    nature    cues    shape    mechanisms    central    adaptive    butterflies    times    time    proliferation    volume    constraints    combine    insects    structures    novelty    ultimate    brain    heliconius    larger    ground    differences    neuroscience    genera    morphology    extensively    lepidoptera    neurons    species    fundamental    insect    bases    origins    asking    appropriate    bodies    model    function    structure    evolution    determined    environment    plan    expansion    connectivity    synthesis    neuroanatomical    conserved    sensory    highest    genetic    functional    integrating    proximate    cohesive    enigmatic    relate    share    profound    density    neural    regions    genomic    connections    volumetric    extract    neuron    closely    size    integration    integrate    storing    behavioural    ask    evolutionary    plays    mushroom    understand    variation    region    mbs    encompassing    memories    functions    varies    basis    mb    developmental    trigger    causes   

Project "MuBoEx" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITY OF BRISTOL 

Organization address
address: BEACON HOUSE QUEENS ROAD
city: BRISTOL
postcode: BS8 1QU
website: www.bristol.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 1˙499˙940 €
 EC max contribution 1˙499˙940 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITY OF BRISTOL UK (BRISTOL) coordinator 1˙159˙470.00
2    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) participant 340˙469.00

Map

 Project objective

The brain plays a central role in the production of adaptive behaviour. It must extract and integrate the most relevant sensory cues from the environment, and combine this information with memories of past experience to trigger appropriate behavioural responses. To fully understand the origins of behavioural novelty we need a detailed understanding of how behavioural differences are generated, both across evolutionary time and during development. This requires the integration of behavioural and neuroanatomical variation, and their genomic and developmental bases.

Mushroom bodies (MBs) are the most enigmatic structures in the insect brain. They have ‘higher order’ functions, integrating sensory information and storing memories of past experience. MBs share a conserved ground plan, but their size and structure varies extensively across species. MB morphology is determined by the number of MB neurons, and the nature and extent of connections they make with other brain regions. As such, they provide a model for asking fundamental questions about how selection, development and functional constraints shape brain evolution.

This project will establish a new study system in evolutionary neuroscience, Heliconius butterflies. MB volume in Heliconius is among the highest across insects, 3-4 times larger than typical for Lepidoptera, including closely related genera. The proposal represents a synthesis of four key objectives that will provide a cohesive understanding of MB expansion in Heliconius, encompassing both proximate and ultimate causes. Specifically, I will ask: i) How does MB expansion enhance behavioural function? ii) How do volumetric changes relate to differences in neuron number, density and connectivity? iii) What developmental mechanisms control region specific changes in neural proliferation? And iv) what is the genetic basis of MB expansion? Addressing these questions will provide profound advances in our understanding of brain evolution.

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The information about "MUBOEX" are provided by the European Opendata Portal: CORDIS opendata.

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