Opendata, web and dolomites

MECHABLASTO SIGNED

Morphogenesis during pre-implantation development: molecular and mechanical regulation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

Project "MECHABLASTO" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙497˙691 €
 EC max contribution 1˙497˙691 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-STG
 Funding Scheme ERC-STG
 Starting year 2018
 Duration (year-month-day) from 2018-02-01   to  2023-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙497˙691.00

Map

 Project objective

During the first days of mammalian development, blastomeres organize themselves into the blastocyst, which implants the embryo into the maternal uterus. Failure to build the blastocyst will result in a miscarriage and yet the mechanisms underlying the construction of the blastocyst are mostly unknown. The blastocyst is sculpted by forces generated by its constituent cells. Without a tool to study the mechanics of the mammalian embryo, it is challenging to identify the molecules and cellular processes controlling morphogenetic forces. Using biophysical methods, I have recently measured the forces shaping the mouse blastocyst and identified cellular processes generating and controlling them. This approach enables the identification of the molecules controlling morphogenesis and constitutes the first step towards a complete theoretical modelling of blastocyst morphogenesis. The aim of this project is to understand the molecular and mechanical aspects of blastocyst morphogenesis. By developing novel biophysical tools for the developing blastocyst, we will measure uncharacterized mechanical properties such as cytoplasmic and luminal pressure, adhesion strength and viscosity. The resulting mechanical map of the blastocyst will help understand the mechanisms of action of genes involved in its morphogenesis. To identify novel candidate genes involved in blastocyst morphogenesis, we will carry out a screen using live high-resolution confocal microscopy of mouse embryos injected with siRNA. Together, this will reveal the molecular, cellular and mechanical processes controlling blastocyst morphogenesis. I expect this to shed light on how blastomeres self-organize into the blastocyst and to reveal the physical laws underlying morphogenesis in general. Importantly, the knowledge and non-invasive biophysical techniques that we will develop will help developing Assisted Reproduction Technologies, which will be greatly beneficial to the fertility of the ageing European population.

 Publications

year authors and title journal last update
List of publications.
2019 Julien G. Dumortier, Mathieu Le Verge-Serandour, Anna Francesca Tortorelli, Annette Mielke, Ludmilla de Plater, Hervé Turlier, Jean-Léon Maître
Hydraulic fracturing and active coarsening position the lumen of the mouse blastocyst
published pages: 465-468, ISSN: 0036-8075, DOI: 10.1126/science.aaw7709
Science 365/6452 2019-10-10
2019 Markus Frederik Schliffka, Jean-Léon Maître
Stay hydrated: basolateral fluids shaping tissues
published pages: 70-77, ISSN: 0959-437X, DOI: 10.1016/j.gde.2019.06.015
Current Opinion in Genetics & Development 57 2019-10-10

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MECHABLASTO" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MECHABLASTO" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

SuperH (2019)

Discovery and Characterization of Hydrogen-Based High-Temperature Superconductors

Read More  

PROGRESS (2019)

The Enemy of the Good: Towards a Theory of Moral Progress

Read More  

InsideChromatin (2019)

Towards Realistic Modelling of Nucleosome Organization Inside Functional Chromatin Domains

Read More