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DynaMO_TB SIGNED

Spatiotemporal regulation of localization and replication of M. tuberculosis in humanmacrophages

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 DynaMO_TB project word cloud

Explore the words cloud of the DynaMO_TB project. It provides you a very rough idea of what is the project "DynaMO_TB" about.

quantify    thereby    soon    localisation    lack    edge    rational    deaths    advancing    stem    cell    limits    cells    cellular    disseminate    million    macrophages    intracellular    3d    cutting    infection    death    uncover    enormous    biology    organisation    regulate    impacts    characterise    2014    populations    surprising    combining    site    health    restrict    relevance    micropattern    world    antibioo    interplay    interactions    components    organelles    group    single    critical    precluded    sr    fundamental    host    gap    appropriate    disease    dynamic    caused    content    human    microscopy    pathogenesis    benefit    unknown    clem    live    super    replicate    correlative    deeper    mtb    pathogen    series    technologies    electron    mycobacterium    sites    adhesive    avenues    interventions    tb    imaging    tuberculosis    precise    resolution    underpins    replication    characterization    refine    successful    vaccines    image    hosts    bacterial   

Project "DynaMO_TB" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙000˙000 €
 EC max contribution 2˙000˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 2˙000˙000.00

Map

 Project objective

Mycobacterium tuberculosis (Mtb) is a very successful intracellular pathogen: in 2014, tuberculosis (TB) caused 1.5 million human deaths (World Health Organisation). To cause disease and disseminate to other hosts, Mtb needs to replicate within human cells. In spite of its enormous relevance for TB pathogenesis, the precise sites of Mtb replication in host cells remain unknown. This surprising gap in knowledge is in part due to the lack of appropriate imaging technologies that have precluded comprehensive understanding of the fundamental biology that underpins Mtb-host cell interactions critical to design rational interventions. Here, we propose to use a series of cutting-edge imaging approaches in human macrophages to: (1) define how the dynamic interactions between Mtb populations and organelles impact Mtb replication; (2) identify critical host and bacterial components that regulate Mtb replication and (3) characterise the host cell death pathways that control Mtb replication. For this, we will benefit from technologies developed in our group to image and quantify Mtb localisation and replication, such as live cell imaging, super resolution (SR) microscopy and correlative live cell 3D- electron microscopy (CLEM). We will refine these approaches to challenge the current limits of cell-based, high content imaging by combining human stem cell-derived macrophages with adhesive micropattern technologies for single cell analysis; this allows us to identify where and when Mtb replicate and how the interplay between host cells and Mtb impacts this process. Together, this proposal can uncover novel cellular pathways defining the intracellular sites that allow or restrict Mtb replication in human macrophages, thereby advancing the fields of both cell and infection biology. The characterization of the site of intracellular replication of Mtb can open avenues for a deeper understanding of human TB pathogenesis and facilitate development of vaccines and antibioo be here soon

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The information about "DYNAMO_TB" are provided by the European Opendata Portal: CORDIS opendata.

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