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SMART-DNA SIGNED

Single Molecule Analytical Raman Tools based on DNA nanostructures

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EC-Contrib. €

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Partnership

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Project "SMART-DNA" data sheet

The following table provides information about the project.

Coordinator
UNIVERSITAET POTSDAM 

Organization address
address: AM NEUEN PALAIS 10
city: POTSDAM
postcode: 14469
website: www.uni-potsdam.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 1˙996˙476 €
 EC max contribution 1˙996˙476 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2023-03-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSITAET POTSDAM DE (POTSDAM) coordinator 1˙996˙476.00

Map

 Project objective

The monitoring of single molecule reactions promises unrivalled insight into chemical reaction mechanisms, but represents one of the most challenging tasks in chemistry. Surface-enhanced Raman scattering (SERS) is a particularly attractive single molecule (SM) technique due to its high chemical specificity, which allows to directly detect relevant intermediates and molecular subpopulations. However, SM-SERS is still at a premature state due to the highly challenging task to place single molecules precisely in nanoscale gaps of plasmonic nanostructures. These are required to provide sufficiently high electromagnetic field enhancement to reach SM sensitivity. The aim of SMART-DNA is to exploit artificial DNA nanostructures to provide sufficient structural control to assemble both, nanoparticles and target molecules, with nanometer precision. By means of novel DNA origami nanostructures the distance between two nanoparticles will be controlled, and at the same time target molecules will be placed at the positions of highest Raman enhancement through DNA aptamers. Apart from Raman enhancement the excitation of the localized surface plasmon resonance of the metallic nanostructures results in other plasmonic effects such as heating and possibly the transfer of hot electrons. This can lead to diffusion, conformational changes or even dissociation of the target molecules. These issues do not only concern SM-SERS, but also make quantitative SERS and the SERS analysis of complex (bio)molecules very challenging. By the improved structural control achieved by SMART-DNA, nanoscale heating and hot electron transfer and their effect on SERS spectra will be studied on an ensemble and a SM level. Finally, reactions induced by plasmonically generated electrons in DNA and DNA modified with electrophilic molecules will be studied by SERS with the aim to develop novel strategies to improve cancer radiation therapies such as the photothermal therapy.

 Publications

year authors and title journal last update
List of publications.
2019 Robin Schürmann, Kenny Ebel, Christophe Nicolas, Aleksandar R. Milosavljević, Ilko Bald
Role of Valence Band States and Plasmonic Enhancement in Electron-Transfer-Induced Transformation of Nitrothiophenol
published pages: 3153-3158, ISSN: 1948-7185, DOI: 10.1021/acs.jpclett.9b00848
The Journal of Physical Chemistry Letters 10/11 2019-11-18
2019 Christian Heck, Yael Michaeli, Ilko Bald, Yuval Ebenstein
Analytical epigenetics: single-molecule optical detection of DNA and histone modifications
published pages: 151-158, ISSN: 0958-1669, DOI: 10.1016/j.copbio.2018.09.006
Current Opinion in Biotechnology 55 2019-11-18
2019 Christian Heck, Yuya Kanehira, Janina Kneipp, Ilko Bald
Amorphous Carbon Generation as a Photocatalytic Reaction on DNA-Assembled Gold and Silver Nanostructures
published pages: 2324, ISSN: 1420-3049, DOI: 10.3390/molecules24122324
Molecules 24/12 2019-11-18
2019 Youngeun Choi, Carsten Schmidt, Philip Tinnefeld, Ilko Bald, Stefan Rödiger
A new reporter design based on DNA origami nanostructures for quantification of short oligonucleotides using microbeads
published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-019-41136-x
Scientific Reports 9/1 2019-11-18

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