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COEXIST TERMINATED

Bacteria-phage-antibiotic interactions in variable environments: a community ecology perspective

Total Cost €

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EC-Contrib. €

0

Partnership

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 COEXIST project word cloud

Explore the words cloud of the COEXIST project. It provides you a very rough idea of what is the project "COEXIST" about.

performance    appear    functions    unlikely    multiple    ecology    community    determinant    maintaining    surprisingly    health    operation    variability    environments    innovative    spatial    time    species    environmental    gut    catalogue    communities    biological    agents    alone    conduct    regulating    maintenance    space    coli    vary    epidemiological    dynamics    escherichia    there    strain    experiments    technologies    parasitism    explanations    nutrient    concentration    effect    nature    diversity    bacterial    lie    temporal    plays    rapid    services    parasites    coexistence    model    viral    ecological    antibiotics    throughput    molecular    linear    leveraging    life    series    interaction    resolution    insights    theory    efforts    ecosystem    evolutionary    paradox    combined    mechanisms    dynamic    poor    phages    hold    inform    critical    theoretical    scales    realisation    antimicrobial    microbial    pathogenic    equilibrium    human    sustaining    naturally   

Project "COEXIST" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

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 Project objective

There is increasing awareness that diversity in microbial communities likely plays a critical role in multiple biological processes, from regulating human health to sustaining ecosystem services. Along with advances in molecular technologies, this realisation has seen a rapid growth in efforts to catalogue microbial life, and yet we still have a surprisingly poor understanding of the mechanisms maintaining microbial diversity. With up to 1,000 different species in the human gut alone, classical ecological explanations for diversity maintenance appear unlikely to hold. A resolution to this coexistence paradox may lie in the dynamic nature of microbial environments. The goal of this project is to investigate whether recent theoretical advances in understanding coexistence in non-equilibrium systems can provide insights into microbial diversity in the presence of viral parasites and antimicrobial agents that naturally vary in concentration in space and time. To this end, I will conduct a series of innovative experiments on multi-strain communities of pathogenic and non-pathogenic Escherichia coli under spatial and temporal variability in nutrient resources, phages and antibiotics. The project is unique in community ecology in leveraging high-throughput methods in a model microbial system of significant human interest; and in its focus on the interaction between non-linear growth functions and environmental variability as a critical determinant of community dynamics. The results will i) enhance our understanding of the role of viral parasitism in regulating diversity; ii) provide insight into emerging theory on the operation of coexistence mechanisms at different spatial and temporal scales; and iii) inform evolutionary and epidemiological research into the combined effect of antibiotics and phages on bacterial performance.

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The information about "COEXIST" are provided by the European Opendata Portal: CORDIS opendata.

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