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COEXIST TERMINATED

Bacteria-phage-antibiotic interactions in variable environments: a community ecology perspective

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 COEXIST project word cloud

Explore the words cloud of the COEXIST project. It provides you a very rough idea of what is the project "COEXIST" about.

appear    scales    environments    phages    model    functions    temporal    diversity    surprisingly    conduct    operation    naturally    human    epidemiological    throughput    ecosystem    biological    resolution    there    evolutionary    coexistence    bacterial    dynamics    efforts    viral    ecology    sustaining    alone    dynamic    performance    effect    plays    parasites    pathogenic    realisation    gut    microbial    services    theory    parasitism    coli    escherichia    experiments    maintaining    species    nutrient    life    strain    innovative    insights    series    environmental    time    interaction    equilibrium    concentration    rapid    spatial    catalogue    lie    nature    space    antimicrobial    multiple    linear    regulating    determinant    inform    molecular    unlikely    technologies    mechanisms    critical    agents    hold    maintenance    community    poor    variability    theoretical    paradox    leveraging    communities    combined    antibiotics    vary    explanations    ecological    health   

Project "COEXIST" data sheet

The following table provides information about the project.

Coordinator
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH 

Organization address
address: Raemistrasse 101
city: ZUERICH
postcode: 8092
website: https://www.ethz.ch/de.html

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-07-01   to  2020-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH CH (ZUERICH) coordinator 187˙419.00

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 Project objective

There is increasing awareness that diversity in microbial communities likely plays a critical role in multiple biological processes, from regulating human health to sustaining ecosystem services. Along with advances in molecular technologies, this realisation has seen a rapid growth in efforts to catalogue microbial life, and yet we still have a surprisingly poor understanding of the mechanisms maintaining microbial diversity. With up to 1,000 different species in the human gut alone, classical ecological explanations for diversity maintenance appear unlikely to hold. A resolution to this coexistence paradox may lie in the dynamic nature of microbial environments. The goal of this project is to investigate whether recent theoretical advances in understanding coexistence in non-equilibrium systems can provide insights into microbial diversity in the presence of viral parasites and antimicrobial agents that naturally vary in concentration in space and time. To this end, I will conduct a series of innovative experiments on multi-strain communities of pathogenic and non-pathogenic Escherichia coli under spatial and temporal variability in nutrient resources, phages and antibiotics. The project is unique in community ecology in leveraging high-throughput methods in a model microbial system of significant human interest; and in its focus on the interaction between non-linear growth functions and environmental variability as a critical determinant of community dynamics. The results will i) enhance our understanding of the role of viral parasitism in regulating diversity; ii) provide insight into emerging theory on the operation of coexistence mechanisms at different spatial and temporal scales; and iii) inform evolutionary and epidemiological research into the combined effect of antibiotics and phages on bacterial performance.

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The information about "COEXIST" are provided by the European Opendata Portal: CORDIS opendata.

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