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NanoBioMade SIGNED

Bioinorganic intracellular synthesis of photo-responsive bio-camouflaged nanomedicines

Total Cost €

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EC-Contrib. €

0

Partnership

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 NanoBioMade project word cloud

Explore the words cloud of the NanoBioMade project. It provides you a very rough idea of what is the project "NanoBioMade" about.

devoted    suggested    fed    roles    bioinorganic    vesicles    loading    fold    constituents    model    first    sophisticated    ground    cobalt    combine    communicate    bio    recycle    made    extracellular    degradation    cells    intracellular    nanomedicines    strategies    iron    exogenous    light    nano    data    wi    magnetic    progression    multiple    ones    obvious    site    vicarious    little    tumour    inherit    breaking    de    delivered    ionic    living    cell    strategy    cancer    organism    innate    physically    instance    rationally    created    generate    nanoparticulate    nanoparticles    homing    mesenchymal    precursors    bioreactors    physiological    smart    transform    profoundly    exposed    biological    natural    prospectively    hydrodynamic    ingredients    man    stress    soluble    tools    unfortunately    salts    functional    encapsulation    preliminary    stem    novo    play    proceedings    synthesized    photothermal    synthesis    100    chemical    basic    events    inspired    engineered   

Project "NanoBioMade" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙967˙000 €
 EC max contribution 1˙967˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-02-01   to  2026-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙967˙000.00

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 Project objective

Exposed to smart man-engineered nanomedicines, cells can profoundly transform and recycle them. To communicate, or in response to exogenous stress, cells generate extracellular vesicles which can play crucial roles in multiple physiological processes, as for instance, and unfortunately, for cancer progression. The goal of this proposal is to combine both biological events to deliver nanomedicines created by cells only, using mesenchymal stem cells as the most relevant cell model. The focus of this proposal on nano-bio-production is three-fold. - In the first instance, I aim to rationally develop novel strategies for bioinorganic intracellular synthesis of nanoparticles. The first aspect will be to demonstrate, as suggested by preliminary data, that nanoparticles degradation products can be de novo-synthesized nanoparticles! And also that nanoparticulate end products can also be obtained when cells are “fed” with soluble ionic salts. The vicarious synthesis using living cells as bioreactors, will allow creating functional, sophisticated and organism-friendly nanoparticles. Basic ingredients and little chemical proceedings should lead to advanced prospectively biological nano-tools. When iron and cobalt constituents will be used as precursors, cells will generate nanoparticles with magnetic and photothermal properties. - The second focus is devoted to nanoparticles biological encapsulation. Indeed, in order to be useful, nanoparticles should be efficiently delivered to the target site. In the strategy to make “100% Bio Made nanomedicines”, it is obvious there are no better delivery systems than the cell’s innate delivery systems, the extracellular vesicles, an especially the ones derived from stem cells, supposed to inherit from their natural tumour homing. Here, ground-breaking physically-inspired (hydrodynamic, light) approaches for production and loading of these vesicles with nanoparticles will be proposed and fully implemented. One specific aim wi

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