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NanoBioMade SIGNED

Bioinorganic intracellular synthesis of photo-responsive bio-camouflaged nanomedicines

Total Cost €

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EC-Contrib. €

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Partnership

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 NanoBioMade project word cloud

Explore the words cloud of the NanoBioMade project. It provides you a very rough idea of what is the project "NanoBioMade" about.

nano    preliminary    breaking    novo    iron    nanomedicines    constituents    bio    vesicles    made    magnetic    combine    little    biological    cancer    bioinorganic    hydrodynamic    basic    rationally    nanoparticles    synthesized    ones    mesenchymal    suggested    natural    data    bioreactors    fold    ionic    de    tumour    cells    organism    transform    sophisticated    created    delivered    tools    multiple    encapsulation    degradation    precursors    communicate    play    physically    stress    soluble    salts    man    strategies    site    light    inspired    functional    chemical    fed    photothermal    synthesis    stem    loading    progression    inherit    cobalt    first    generate    strategy    model    profoundly    exogenous    wi    recycle    cell    exposed    living    innate    prospectively    nanoparticulate    smart    obvious    100    engineered    instance    homing    devoted    events    vicarious    extracellular    ground    intracellular    ingredients    physiological    roles    unfortunately    proceedings   

Project "NanoBioMade" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙967˙000 €
 EC max contribution 1˙967˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2019-COG
 Funding Scheme ERC-COG
 Starting year 2021
 Duration (year-month-day) from 2021-02-01   to  2026-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙967˙000.00

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 Project objective

Exposed to smart man-engineered nanomedicines, cells can profoundly transform and recycle them. To communicate, or in response to exogenous stress, cells generate extracellular vesicles which can play crucial roles in multiple physiological processes, as for instance, and unfortunately, for cancer progression. The goal of this proposal is to combine both biological events to deliver nanomedicines created by cells only, using mesenchymal stem cells as the most relevant cell model. The focus of this proposal on nano-bio-production is three-fold. - In the first instance, I aim to rationally develop novel strategies for bioinorganic intracellular synthesis of nanoparticles. The first aspect will be to demonstrate, as suggested by preliminary data, that nanoparticles degradation products can be de novo-synthesized nanoparticles! And also that nanoparticulate end products can also be obtained when cells are “fed” with soluble ionic salts. The vicarious synthesis using living cells as bioreactors, will allow creating functional, sophisticated and organism-friendly nanoparticles. Basic ingredients and little chemical proceedings should lead to advanced prospectively biological nano-tools. When iron and cobalt constituents will be used as precursors, cells will generate nanoparticles with magnetic and photothermal properties. - The second focus is devoted to nanoparticles biological encapsulation. Indeed, in order to be useful, nanoparticles should be efficiently delivered to the target site. In the strategy to make “100% Bio Made nanomedicines”, it is obvious there are no better delivery systems than the cell’s innate delivery systems, the extracellular vesicles, an especially the ones derived from stem cells, supposed to inherit from their natural tumour homing. Here, ground-breaking physically-inspired (hydrodynamic, light) approaches for production and loading of these vesicles with nanoparticles will be proposed and fully implemented. One specific aim wi

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