Explore the words cloud of the EMERGE project. It provides you a very rough idea of what is the project "EMERGE" about.
The following table provides information about the project.
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
|Coordinator Country||Germany [DE]|
|Total cost||1˙998˙750 €|
|EC max contribution||1˙998˙750 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-03-01 to 2023-02-28|
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|1||MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV||DE (Munich)||coordinator||1˙998˙750.00|
Heterogeneity within the endothelium is increasingly recognized in both normal and disease conditions, influencing vascular architecture, structure, and function. The diverse phenotypes that endothelial cells (ECs) adopt suggest substantial plasticity and indicate that heterogeneity is a core property that enables ECs to fulfill their tissue-specific tasks. However, the molecular basis for tissue-specific endothelial differentiation and heterogeneity remains largely unknown. In this project, we will study the impact of environmental context on endothelial specialization and focus on the emerging relationship between metabolism, epigenetics, and cellular differentiation. We hypothesize that organ-specific differences in endothelial metabolic state, through altered epigenetics, promote specialization and thereby contribute to heterogeneity within the vascular system. The proposal rests on the notion that many of the enzymes that erase epigenetic modifications (from DNA and histones) are exquisitely sensitive to changes in metabolism as they utilize cosubstrates that are generated by cellular metabolism. Using a combination of state-of-the-art genetics, high-resolution imaging, metabolomics, and biochemistry, we will study the role of these epigenetic mechanisms for general and organ-specific blood vessel formation (Objective I) and determine their regulation by metabolic and vascular differentiation signals (Objective II). Moreover, we will explore whether metabolic changes during obesity and aging impact the maintenance of endothelial specialization, and assess whether deregulation of metabolic-epigenetic signalling leads to endothelial malfunction and organ failure (Objective III). We trust that the knowledge gained through this project will provide a conceptual framework for understanding how environmental context can drive vascular heterogeneity and, more generally, how alterations in metabolism and nutrition might contribute to vascular-related diseases.
|year||authors and title||journal||last update|
Lim R, Sugino T, Nolte H, Andrade J, Zimmermann B, Shi C, Doddaballapur A, Ong YT, Wilhelm K, Fasse JWD, Ernst A, Kaulich M, Husnjak K, Boettger T, Guenther S, Braun T, KrÃ¼ger M, Benedito R, Dikic I, Potente M
Deubiquitinase USP10 regulates Notch signaling in the endothelium
published pages: 364(6436):188-19, ISSN: 0036-8075, DOI:
Meghan Riddell, Akiko Nakayama, Takao Hikita, Fatemeh Mirzapourshafiyi, Takuji Kawamura, Ayesha Pasha, Mengnan Li, Mikio Masuzawa, Mario Looso, Tim Steinbacher, Klaus Ebnet, Michael Potente, Tomonori Hirose, Shigeo Ohno, Ingrid Fleming, Stefan GattenlÃ¶hner, Phyu P. Aung, Thuy Phung, Osamu Yamasaki, Teruki Yanagi, Hiroshi Umemura, Masanori Nakayama
aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-07739-0
|Nature Communications 9/1||2019-10-30|
Radiance Lim, Michael Potente
Top-NOTCH Regulation of Cardiac Metabolism
published pages: 2609-2612, ISSN: 0009-7322, DOI: 10.1161/circulationaha.118.033669
Jorge Andrade, Michael Potente
Endothelial metabolismâ€”more complex (III) than previously thought
published pages: , ISSN: 2522-5812, DOI:
Oliver A. Stone, Mohamed El-Brolosy, Kerstin Wilhelm, Xiaojing Liu, Ana M. RomÃ£o, Elisabetta Grillo, Jason K. H. Lai, Stefan GÃ¼nther, Sylvia Jeratsch, Carsten Kuenne, I-Ching Lee, Thomas Braun, Massimo M. Santoro, Jason W. Locasale, Michael Potente, Didier Y. R. Stainier
Loss of pyruvate kinase M2 limits growth and triggers innate immune signaling in endothelial cells
published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06406-8
|Nature Communications 9/1||2019-10-30|
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