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UTERUS SIGNED

Unravelling gamma delta T cell emergence and responses in the uterus

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UTERUS project word cloud

Explore the words cloud of the UTERUS project. It provides you a very rough idea of what is the project "UTERUS" about.

constitute    receptor    bear    intraepithelial    activation    btnls    gd17    intestinal    niches    cellular    sites    functional    17a    ontogeny    humans    effect    bacterial    uterine    clinical    cues    thereby    direct    shown    insult    body    cytokine    damage    play    blood    populations    hindering    protection    exacerbation    epithelial    infections    fungal    infection    close    alterations    barrier    gd    female    small    enriched    cells    lymphocytes    immune    expressed    tissues    arguably    requirement    contact    promptly    driving    repair    promotion    reproductive    location    delta    il    precommitted    reside    proportion    pathogenic    pathogens    central    conserved    position    basic    inflammatory    drug    embryonic    pro    guiding    places    tumorigenic    invariant    standpoint    reveal    tract    fracture    termed    butyrophilin    molecules    epidermal    proteins    least    cell    gamma    transformation    btnl    limiting    secreting    homing    thought    tissue   

Project "UTERUS" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Gamma delta (gd) T cells constitute a small proportion of blood lymphocytes, but are enriched at barrier sites, where they reside in close contact with epithelial cells. Their location at sites of pathogenic insult and cellular transformation, together with their ability to promptly respond to tissue alterations, places them in a central position in immune protection. We have shown that epithelial molecules direct the development of tissue-specific populations of gd T cells. Indeed, we have identified a role for epithelial-expressed butyrophilin-like (Btnl) proteins in driving the development of epidermal and intraepithelial gd T cells. Importantly, the requirement for Btnls is conserved in intestinal gd T cells in humans. In this project, we will focus on uterine gd T cells, which are arguably one of the least understood populations of gd T cells. These cells bear a specific, invariant T cell receptor, and are thought to become precommitted to an IL-17A-secreting programme during early ontogeny. In other tissues, these cells, termed gd17, can rapidly produce the pro-inflammatory cytokine IL-17A following infection, thereby contributing to limiting infection with bacterial and fungal pathogens. In addition, gd17 cells have been shown to play a role in tissue repair, including promotion of fracture repair. However, the inflammatory effects of IL-17A can also lead to exacerbation of tissue damage and to a pro-tumorigenic effect. In this project, we will determine the functional characteristics of uterine gd T cells, and identify novel factors guiding the development and homing of these cells. Understanding the cues driving gd T cell development and activation at specific body niches is not only essential from a basic research standpoint, but may reveal novel drug targets for various clinical conditions, particularly in the face of emerging infections targeting the female reproductive tract and hindering embryonic development.

 Publications

year authors and title journal last update
List of publications.
2019 Leticia Monin, Emily M. Whettlock, Victoria Male
Immune responses in the human female reproductive tract
published pages: , ISSN: 0019-2805, DOI: 10.1111/imm.13136
Immunology 2020-04-24

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