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UTERUS SIGNED

Unravelling gamma delta T cell emergence and responses in the uterus

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 UTERUS project word cloud

Explore the words cloud of the UTERUS project. It provides you a very rough idea of what is the project "UTERUS" about.

btnls    blood    drug    epithelial    thought    cues    close    gd17    shown    standpoint    reside    inflammatory    clinical    intraepithelial    protection    gd    17a    activation    termed    epidermal    sites    cytokine    central    least    invariant    arguably    embryonic    secreting    cell    butyrophilin    body    promptly    basic    exacerbation    alterations    humans    pathogens    fracture    repair    transformation    functional    bear    promotion    receptor    proteins    limiting    constitute    direct    precommitted    female    tract    guiding    niches    driving    proportion    pro    conserved    ontogeny    homing    damage    immune    effect    il    contact    play    tissues    bacterial    requirement    small    intestinal    uterine    location    cellular    insult    pathogenic    position    lymphocytes    tumorigenic    hindering    places    infections    thereby    enriched    reproductive    populations    btnl    molecules    reveal    cells    gamma    barrier    expressed    fungal    delta    tissue    infection   

Project "UTERUS" data sheet

The following table provides information about the project.

Coordinator
THE FRANCIS CRICK INSTITUTE LIMITED 

Organization address
address: 1 MIDLAND ROAD
city: LONDON
postcode: NW1 1AT
website: www.crick.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 183˙454 €
 EC max contribution 183˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-03-01   to  2020-02-29

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE FRANCIS CRICK INSTITUTE LIMITED UK (LONDON) coordinator 183˙454.00

Map

 Project objective

Gamma delta (gd) T cells constitute a small proportion of blood lymphocytes, but are enriched at barrier sites, where they reside in close contact with epithelial cells. Their location at sites of pathogenic insult and cellular transformation, together with their ability to promptly respond to tissue alterations, places them in a central position in immune protection. We have shown that epithelial molecules direct the development of tissue-specific populations of gd T cells. Indeed, we have identified a role for epithelial-expressed butyrophilin-like (Btnl) proteins in driving the development of epidermal and intraepithelial gd T cells. Importantly, the requirement for Btnls is conserved in intestinal gd T cells in humans. In this project, we will focus on uterine gd T cells, which are arguably one of the least understood populations of gd T cells. These cells bear a specific, invariant T cell receptor, and are thought to become precommitted to an IL-17A-secreting programme during early ontogeny. In other tissues, these cells, termed gd17, can rapidly produce the pro-inflammatory cytokine IL-17A following infection, thereby contributing to limiting infection with bacterial and fungal pathogens. In addition, gd17 cells have been shown to play a role in tissue repair, including promotion of fracture repair. However, the inflammatory effects of IL-17A can also lead to exacerbation of tissue damage and to a pro-tumorigenic effect. In this project, we will determine the functional characteristics of uterine gd T cells, and identify novel factors guiding the development and homing of these cells. Understanding the cues driving gd T cell development and activation at specific body niches is not only essential from a basic research standpoint, but may reveal novel drug targets for various clinical conditions, particularly in the face of emerging infections targeting the female reproductive tract and hindering embryonic development.

 Publications

year authors and title journal last update
List of publications.
2019 Leticia Monin, Emily M. Whettlock, Victoria Male
Immune responses in the human female reproductive tract
published pages: , ISSN: 0019-2805, DOI: 10.1111/imm.13136
Immunology 2020-04-24

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