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BRONC SIGNED

Behavioral demand-driven dynamic reorganisation of cortical networks revealed by simultaneous wide-field optical imaging and optogenetic stimulation mapping in task-performing mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BRONC project word cloud

Explore the words cloud of the BRONC project. It provides you a very rough idea of what is the project "BRONC" about.

reorganization    lab    single    neural    marmoset    neuronal    patients    calcium    elucidating    disorder    gene    clinical    dynamic    mice    mapping    selective    indicators    sophisticate    encoded    view    monkey    psychiatric    laboratory    simultaneously    networks    voltage    paradigm    mouse    mechanism    memory    imaging    suited    action    contribution    career    integrate    cortical    techniques    stimulation    stop    brain    optogenetic    reorganisation    small    technologies    circuits    roles    human    layers    local    disorders    integration    plans    humans    point    genetically    transferred    causal    monkeys    psychophysics    optogenetics    obsessive    plan    science    poorly    performing    functions    differential    visualize    spatiotemporally    repeating    primate    mental    acquire    modification    neuroscience    impacts    transfers    actions    switching    circuit    macaque    introduction    cognitive    toward    reorganise    revealed    combine    observation    interneurons    compulsive    host    wish    spatiotemporal    researcher    beneficial    global    core    optical    behavior    society    mechanisms    er   

Project "BRONC" data sheet

The following table provides information about the project.

Coordinator		 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

CAREER PLAN: The Experienced Researcher (ER) has revealed causal neural mechanism of cognitive memory by optogenetics and psychophysics in macaque monkeys. ER wish to combine cognitive neuroscience in monkeys and circuit-based neuroscience in mice to build a new field to study cognitive functions at the level of genetically-defined circuits. Thus, ER plans to develop and acquire new technologies in a top laboratory investigating the mouse brain.

INTRODUCTION: We humans can quickly change what we do. This would require dynamic reorganization of brain networks. Recent studies have revealed differential roles of cortical layers and interneurons in local neuronal circuits. However, a mechanism that reorganise cortical networks to integrate local circuit processing has been poorly understood, while this is a core principle of the brain to work.

OBJECTIVE: Elucidating mechanisms of global integration of local processing from a view point of spatiotemporally-selective causal actions of different cortical layers and interneurons. APPROACH: Spatiotemporal actions of cortical layers and interneurons in task-performing mice will be observed by wide-field optical imaging with genetically-encoded calcium or voltage indicators. Simultaneously, optogenetic stimulation mapping to layers and interneurons will visualize their causal contribution to global processing and task execution. IMPACTS: 1. Mechanisms of dynamic cortical reorganisation for switching behavior have a clinical impact for common psychiatric disorders such as obsessive-compulsive disorder in which patients can not stop repeating a single action. 2. ER transfers knowledge in monkey cognitive science to the host lab to sophisticate mouse paradigm. 3.Techniques developed by ER will be transferred to marmoset, a small non-human primate suited for gene-modification and optical observation. This program is highly beneficial for the society and the career of ER toward understanding of human mental functions.

 Publications

year authors and title journal last update
List of publications.
2019 Johannes M. Mayrhofer, Sami El-Boustani, Georgios Foustoukos, Matthieu Auffret, Keita Tamura, Carl C.H. Petersen
Distinct Contributions of Whisker Sensory Cortex and Tongue-Jaw Motor Cortex in a Goal-Directed Sensorimotor Transformation
published pages: 1034-1043.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.07.008 		Neuron 103/6 2019-12-17

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