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BRONC SIGNED

Behavioral demand-driven dynamic reorganisation of cortical networks revealed by simultaneous wide-field optical imaging and optogenetic stimulation mapping in task-performing mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BRONC project word cloud

Explore the words cloud of the BRONC project. It provides you a very rough idea of what is the project "BRONC" about.

integrate    er    modification    action    host    stimulation    researcher    mapping    optical    small    beneficial    mental    cognitive    switching    circuit    technologies    visualize    reorganization    human    circuits    disorder    encoded    layers    local    poorly    neuroscience    calcium    behavior    mechanism    psychophysics    plans    monkey    mechanisms    global    introduction    roles    spatiotemporal    psychiatric    optogenetic    dynamic    marmoset    view    elucidating    monkeys    optogenetics    point    actions    integration    society    voltage    toward    memory    neuronal    mouse    core    differential    mice    repeating    networks    plan    patients    wish    impacts    clinical    obsessive    causal    acquire    science    spatiotemporally    combine    single    reorganise    indicators    brain    transferred    compulsive    contribution    selective    reorganisation    primate    macaque    humans    transfers    neural    interneurons    revealed    observation    techniques    sophisticate    functions    laboratory    cortical    disorders    genetically    gene    stop    simultaneously    lab    suited    performing    paradigm    career    imaging   

Project "BRONC" data sheet

The following table provides information about the project.

Coordinator		 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

CAREER PLAN: The Experienced Researcher (ER) has revealed causal neural mechanism of cognitive memory by optogenetics and psychophysics in macaque monkeys. ER wish to combine cognitive neuroscience in monkeys and circuit-based neuroscience in mice to build a new field to study cognitive functions at the level of genetically-defined circuits. Thus, ER plans to develop and acquire new technologies in a top laboratory investigating the mouse brain.

INTRODUCTION: We humans can quickly change what we do. This would require dynamic reorganization of brain networks. Recent studies have revealed differential roles of cortical layers and interneurons in local neuronal circuits. However, a mechanism that reorganise cortical networks to integrate local circuit processing has been poorly understood, while this is a core principle of the brain to work.

OBJECTIVE: Elucidating mechanisms of global integration of local processing from a view point of spatiotemporally-selective causal actions of different cortical layers and interneurons. APPROACH: Spatiotemporal actions of cortical layers and interneurons in task-performing mice will be observed by wide-field optical imaging with genetically-encoded calcium or voltage indicators. Simultaneously, optogenetic stimulation mapping to layers and interneurons will visualize their causal contribution to global processing and task execution. IMPACTS: 1. Mechanisms of dynamic cortical reorganisation for switching behavior have a clinical impact for common psychiatric disorders such as obsessive-compulsive disorder in which patients can not stop repeating a single action. 2. ER transfers knowledge in monkey cognitive science to the host lab to sophisticate mouse paradigm. 3.Techniques developed by ER will be transferred to marmoset, a small non-human primate suited for gene-modification and optical observation. This program is highly beneficial for the society and the career of ER toward understanding of human mental functions.

 Publications

year authors and title journal last update
List of publications.
2019 Johannes M. Mayrhofer, Sami El-Boustani, Georgios Foustoukos, Matthieu Auffret, Keita Tamura, Carl C.H. Petersen
Distinct Contributions of Whisker Sensory Cortex and Tongue-Jaw Motor Cortex in a Goal-Directed Sensorimotor Transformation
published pages: 1034-1043.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.07.008 		Neuron 103/6 2019-12-17

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