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BRONC SIGNED

Behavioral demand-driven dynamic reorganisation of cortical networks revealed by simultaneous wide-field optical imaging and optogenetic stimulation mapping in task-performing mice

Total Cost €

0

EC-Contrib. €

0

Partnership

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 BRONC project word cloud

Explore the words cloud of the BRONC project. It provides you a very rough idea of what is the project "BRONC" about.

psychophysics    mice    disorders    monkeys    elucidating    cortical    calcium    revealed    human    genetically    stop    interneurons    dynamic    selective    primate    local    layers    memory    reorganisation    gene    modification    functions    cognitive    paradigm    poorly    voltage    spatiotemporal    patients    laboratory    visualize    simultaneously    disorder    mapping    humans    lab    view    differential    actions    causal    acquire    brain    host    spatiotemporally    indicators    obsessive    action    roles    optogenetics    introduction    er    techniques    reorganization    circuit    reorganise    global    science    plans    encoded    circuits    mental    sophisticate    mechanisms    imaging    compulsive    clinical    neural    core    small    transferred    contribution    performing    neuronal    repeating    integration    suited    mechanism    behavior    integrate    switching    wish    transfers    toward    psychiatric    optogenetic    single    point    career    optical    neuroscience    beneficial    technologies    networks    macaque    plan    mouse    marmoset    combine    researcher    monkey    society    observation    impacts    stimulation   

Project "BRONC" data sheet

The following table provides information about the project.

Coordinator		 ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-11-01   to  2020-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

CAREER PLAN: The Experienced Researcher (ER) has revealed causal neural mechanism of cognitive memory by optogenetics and psychophysics in macaque monkeys. ER wish to combine cognitive neuroscience in monkeys and circuit-based neuroscience in mice to build a new field to study cognitive functions at the level of genetically-defined circuits. Thus, ER plans to develop and acquire new technologies in a top laboratory investigating the mouse brain.

INTRODUCTION: We humans can quickly change what we do. This would require dynamic reorganization of brain networks. Recent studies have revealed differential roles of cortical layers and interneurons in local neuronal circuits. However, a mechanism that reorganise cortical networks to integrate local circuit processing has been poorly understood, while this is a core principle of the brain to work.

OBJECTIVE: Elucidating mechanisms of global integration of local processing from a view point of spatiotemporally-selective causal actions of different cortical layers and interneurons. APPROACH: Spatiotemporal actions of cortical layers and interneurons in task-performing mice will be observed by wide-field optical imaging with genetically-encoded calcium or voltage indicators. Simultaneously, optogenetic stimulation mapping to layers and interneurons will visualize their causal contribution to global processing and task execution. IMPACTS: 1. Mechanisms of dynamic cortical reorganisation for switching behavior have a clinical impact for common psychiatric disorders such as obsessive-compulsive disorder in which patients can not stop repeating a single action. 2. ER transfers knowledge in monkey cognitive science to the host lab to sophisticate mouse paradigm. 3.Techniques developed by ER will be transferred to marmoset, a small non-human primate suited for gene-modification and optical observation. This program is highly beneficial for the society and the career of ER toward understanding of human mental functions.

 Publications

year authors and title journal last update
List of publications.
2019 Johannes M. Mayrhofer, Sami El-Boustani, Georgios Foustoukos, Matthieu Auffret, Keita Tamura, Carl C.H. Petersen
Distinct Contributions of Whisker Sensory Cortex and Tongue-Jaw Motor Cortex in a Goal-Directed Sensorimotor Transformation
published pages: 1034-1043.e5, ISSN: 0896-6273, DOI: 10.1016/j.neuron.2019.07.008 		Neuron 103/6 2019-12-17

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