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BRIDGING SIGNED

The function of membrane tethering in plant intercellular communication

Total Cost €

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EC-Contrib. €

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Partnership

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 BRIDGING project word cloud

Explore the words cloud of the BRIDGING project. It provides you a very rough idea of what is the project "BRIDGING" about.

plant    reticulum    unidentified    mechanisms    contact    endoplasmic    apart    tethering    enigma    pores    cell    date    animal    pd    indispensable    organelle    10nm    coordinate    communication    unclear    interconnect    junctions    complementary    talk    ultra    benefit    er    pore    uncover    striking    3d    intercellular    flux    molecular    integrates    mechanism    multicellular    running    strand    bioinformatic    single    individual    plasma    plants    first    setting    pm    dynamics    organelles    radically    extremely    time    establishing    contacts    remarkable    fundamental    machines    plasmodesmata    integrate    spokes    molecules    elucidate    biology    cellular    pursue    apposition    membrane    tight    attain    cytoplasmic    sites    situation    decisive    mediated    organisation    body    life    architecture    imaging    don    function    biophysical    direct    signalling    central    critical    complete    continuity    question    environmental    pioneer    defence    fact    multicellularity    tethered    cells    resolution    perspective    organism    proteomic    coordinates    cross   

Project "BRIDGING" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙840 €
 EC max contribution 1˙999˙840 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙999˙840.00

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 Project objective

Intercellular communication is critical for multicellularity. It coordinates the activities within individual cells to support the function of an organism as a whole. Plants have developed remarkable cellular machines -the Plasmodesmata (PD) pores- which interconnect every single cell within the plant body, establishing direct membrane and cytoplasmic continuity, a situation unique to plants. PD are indispensable for plant life. They control the flux of molecules between cells and are decisive for development, environmental adaptation and defence signalling. However, how PD integrate signalling to coordinate responses at a multicellular level remains unclear. A striking feature of PD organisation, setting them apart from animal cell junctions, is a strand of endoplasmic reticulum (ER) running through the pore, tethered extremely tight (~10nm) to the plasma membrane (PM) by unidentified “spokes”. To date, the function of ER-PM contacts at PD remains a complete enigma. We don’t know how and why the two organelles come together at PD cellular junctions. I recently proposed that ER-PM tethering is in fact central to PD function. In this project I will investigate the question of how integrated cellular responses benefit from organelle cross-talk at PD. The project integrates proteomic/bioinformatic approaches, biophysical/modelling methods and ultra-high resolution 3D imaging into molecular cell biology of plant cell-to-cell communication and will, for the first time, directly address the mechanism and function of ER-PM contacts at PD. We will pursue three complementary objectives to attain our goal: 1) Identify the mechanisms of PD membrane-tethering at the molecular level 2) Elucidate the dynamics and 3D architecture of ER-PM contact sites at PD 3) Uncover the function of ER-PM apposition for plant intercellular communication. Overall, the project will pioneer a radically new perspective on PD-mediated cell-to-cell communication, a fundamental aspect of plant biology

 Publications

year authors and title journal last update
List of publications.
2019 Emmanuelle M. Bayer, Tito Calì, Francesca Giordano, Anne Hamacher-Brady, Luca Pellegrini
EMBO Workshop: Membrane Contact Sites in Health and Disease
published pages: 251525641982593, ISSN: 2515-2564, DOI: 10.1177/2515256419825931
Contact 2 2020-02-06
2019 Magali S. Grison, Philip Kirk, Marie L. Brault, Xu Na Wu, Waltraud X. Schulze, Yoselin Benitez-Alfonso, Françoise Immel, Emmanuelle M. Bayer
Plasma Membrane-Associated Receptor-like Kinases Relocalize to Plasmodesmata in Response to Osmotic Stress
published pages: 142-160, ISSN: 0032-0889, DOI: 10.1104/pp.19.00473
Plant Physiology 181/1 2020-02-06
2019 Jules D. Petit, Françoise Immel, Laurence Lins, Emmanuelle M. Bayer
Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites?
published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2019.00198
Frontiers in Plant Science 10 2020-02-06
2019 Dawei Yan, Shri Ram Yadav, Andrea Paterlini, William J. Nicolas, Jules D. Petit, Lysiane Brocard, Ilya Belevich, Magali S. Grison, Anne Vaten, Leila Karami, Sedeer el-Showk, Jung-Youn Lee, Gosia M. Murawska, Jenny Mortimer, Michael Knoblauch, Eija Jokitalo, Jonathan E. Markham, Emmanuelle M. Bayer, Ykä Helariutta
Sphingolipid biosynthesis modulates plasmodesmal ultrastructure and phloem unloading
published pages: 604-615, ISSN: 2055-0278, DOI: 10.1038/s41477-019-0429-5
Nature Plants 5/6 2020-02-06
2019 Marie L Brault, Jules D Petit, Françoise Immel, William J Nicolas, Marie Glavier, Lysiane Brocard, Amèlia Gaston, Mathieu Fouché, Timothy J Hawkins, Jean‐Marc Crowet, Magali S Grison, Véronique Germain, Marion Rocher, Max Kraner, Vikram Alva, Stéphane Claverol, Andrea Paterlini, Ykä Helariutta, Magali Deleu, Laurence Lins, Jens Tilsner, Emmanuelle M Bayer
Multiple C2 domains and transmembrane region proteins ( MCTP s) tether membranes at plasmodesmata
published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201847182
EMBO reports 20/8 2020-02-06

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