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BRIDGING SIGNED

The function of membrane tethering in plant intercellular communication

Total Cost €

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EC-Contrib. €

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Partnership

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 BRIDGING project word cloud

Explore the words cloud of the BRIDGING project. It provides you a very rough idea of what is the project "BRIDGING" about.

biophysical    pursue    cell    pm    junctions    signalling    organelles    cross    function    mechanism    elucidate    central    single    extremely    animal    apposition    don    imaging    cells    striking    ultra    plasmodesmata    machines    coordinate    contacts    pore    sites    architecture    date    perspective    er    contact    organisation    pores    direct    radically    dynamics    tight    coordinates    pd    3d    multicellular    proteomic    indispensable    interconnect    talk    plasma    continuity    endoplasmic    body    situation    enigma    flux    organism    setting    integrate    bioinformatic    unidentified    communication    cytoplasmic    uncover    attain    pioneer    defence    plants    biology    question    life    intercellular    complementary    integrates    tethering    plant    organelle    cellular    benefit    time    critical    mediated    membrane    resolution    reticulum    apart    individual    decisive    spokes    environmental    molecules    complete    10nm    mechanisms    establishing    tethered    running    strand    fact    remarkable    first    unclear    molecular    fundamental    multicellularity   

Project "BRIDGING" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙999˙840 €
 EC max contribution 1˙999˙840 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-COG
 Funding Scheme ERC-COG
 Starting year 2018
 Duration (year-month-day) from 2018-06-01   to  2023-05-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙999˙840.00

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 Project objective

Intercellular communication is critical for multicellularity. It coordinates the activities within individual cells to support the function of an organism as a whole. Plants have developed remarkable cellular machines -the Plasmodesmata (PD) pores- which interconnect every single cell within the plant body, establishing direct membrane and cytoplasmic continuity, a situation unique to plants. PD are indispensable for plant life. They control the flux of molecules between cells and are decisive for development, environmental adaptation and defence signalling. However, how PD integrate signalling to coordinate responses at a multicellular level remains unclear. A striking feature of PD organisation, setting them apart from animal cell junctions, is a strand of endoplasmic reticulum (ER) running through the pore, tethered extremely tight (~10nm) to the plasma membrane (PM) by unidentified “spokes”. To date, the function of ER-PM contacts at PD remains a complete enigma. We don’t know how and why the two organelles come together at PD cellular junctions. I recently proposed that ER-PM tethering is in fact central to PD function. In this project I will investigate the question of how integrated cellular responses benefit from organelle cross-talk at PD. The project integrates proteomic/bioinformatic approaches, biophysical/modelling methods and ultra-high resolution 3D imaging into molecular cell biology of plant cell-to-cell communication and will, for the first time, directly address the mechanism and function of ER-PM contacts at PD. We will pursue three complementary objectives to attain our goal: 1) Identify the mechanisms of PD membrane-tethering at the molecular level 2) Elucidate the dynamics and 3D architecture of ER-PM contact sites at PD 3) Uncover the function of ER-PM apposition for plant intercellular communication. Overall, the project will pioneer a radically new perspective on PD-mediated cell-to-cell communication, a fundamental aspect of plant biology

 Publications

year authors and title journal last update
List of publications.
2019 Emmanuelle M. Bayer, Tito Calì, Francesca Giordano, Anne Hamacher-Brady, Luca Pellegrini
EMBO Workshop: Membrane Contact Sites in Health and Disease
published pages: 251525641982593, ISSN: 2515-2564, DOI: 10.1177/2515256419825931
Contact 2 2020-02-06
2019 Magali S. Grison, Philip Kirk, Marie L. Brault, Xu Na Wu, Waltraud X. Schulze, Yoselin Benitez-Alfonso, Françoise Immel, Emmanuelle M. Bayer
Plasma Membrane-Associated Receptor-like Kinases Relocalize to Plasmodesmata in Response to Osmotic Stress
published pages: 142-160, ISSN: 0032-0889, DOI: 10.1104/pp.19.00473
Plant Physiology 181/1 2020-02-06
2019 Jules D. Petit, Françoise Immel, Laurence Lins, Emmanuelle M. Bayer
Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites?
published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2019.00198
Frontiers in Plant Science 10 2020-02-06
2019 Dawei Yan, Shri Ram Yadav, Andrea Paterlini, William J. Nicolas, Jules D. Petit, Lysiane Brocard, Ilya Belevich, Magali S. Grison, Anne Vaten, Leila Karami, Sedeer el-Showk, Jung-Youn Lee, Gosia M. Murawska, Jenny Mortimer, Michael Knoblauch, Eija Jokitalo, Jonathan E. Markham, Emmanuelle M. Bayer, Ykä Helariutta
Sphingolipid biosynthesis modulates plasmodesmal ultrastructure and phloem unloading
published pages: 604-615, ISSN: 2055-0278, DOI: 10.1038/s41477-019-0429-5
Nature Plants 5/6 2020-02-06
2019 Marie L Brault, Jules D Petit, Françoise Immel, William J Nicolas, Marie Glavier, Lysiane Brocard, Amèlia Gaston, Mathieu Fouché, Timothy J Hawkins, Jean‐Marc Crowet, Magali S Grison, Véronique Germain, Marion Rocher, Max Kraner, Vikram Alva, Stéphane Claverol, Andrea Paterlini, Ykä Helariutta, Magali Deleu, Laurence Lins, Jens Tilsner, Emmanuelle M Bayer
Multiple C2 domains and transmembrane region proteins ( MCTP s) tether membranes at plasmodesmata
published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201847182
EMBO reports 20/8 2020-02-06

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