Explore the words cloud of the BRIDGING project. It provides you a very rough idea of what is the project "BRIDGING" about.
The following table provides information about the project.
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
|Coordinator Country||France [FR]|
|Total cost||1˙999˙840 €|
|EC max contribution||1˙999˙840 € (100%)|
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
|Duration (year-month-day)||from 2018-06-01 to 2023-05-31|
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|1||CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS||FR (PARIS)||coordinator||1˙999˙840.00|
Intercellular communication is critical for multicellularity. It coordinates the activities within individual cells to support the function of an organism as a whole. Plants have developed remarkable cellular machines -the Plasmodesmata (PD) pores- which interconnect every single cell within the plant body, establishing direct membrane and cytoplasmic continuity, a situation unique to plants. PD are indispensable for plant life. They control the flux of molecules between cells and are decisive for development, environmental adaptation and defence signalling. However, how PD integrate signalling to coordinate responses at a multicellular level remains unclear. A striking feature of PD organisation, setting them apart from animal cell junctions, is a strand of endoplasmic reticulum (ER) running through the pore, tethered extremely tight (~10nm) to the plasma membrane (PM) by unidentified “spokes”. To date, the function of ER-PM contacts at PD remains a complete enigma. We don’t know how and why the two organelles come together at PD cellular junctions. I recently proposed that ER-PM tethering is in fact central to PD function. In this project I will investigate the question of how integrated cellular responses benefit from organelle cross-talk at PD. The project integrates proteomic/bioinformatic approaches, biophysical/modelling methods and ultra-high resolution 3D imaging into molecular cell biology of plant cell-to-cell communication and will, for the first time, directly address the mechanism and function of ER-PM contacts at PD. We will pursue three complementary objectives to attain our goal: 1) Identify the mechanisms of PD membrane-tethering at the molecular level 2) Elucidate the dynamics and 3D architecture of ER-PM contact sites at PD 3) Uncover the function of ER-PM apposition for plant intercellular communication. Overall, the project will pioneer a radically new perspective on PD-mediated cell-to-cell communication, a fundamental aspect of plant biology
|year||authors and title||journal||last update|
Emmanuelle M. Bayer, Tito CalÃ¬, Francesca Giordano, Anne Hamacher-Brady, Luca Pellegrini
EMBO Workshop: Membrane Contact Sites in Health and Disease
published pages: 251525641982593, ISSN: 2515-2564, DOI: 10.1177/2515256419825931
Magali S. Grison, Philip Kirk, Marie L. Brault, Xu Na Wu, Waltraud X. Schulze, Yoselin Benitez-Alfonso, FranÃ§oise Immel, Emmanuelle M. Bayer
Plasma Membrane-Associated Receptor-like Kinases Relocalize to Plasmodesmata in Response to Osmotic Stress
published pages: 142-160, ISSN: 0032-0889, DOI: 10.1104/pp.19.00473
|Plant Physiology 181/1||2020-02-06|
Jules D. Petit, FranÃ§oise Immel, Laurence Lins, Emmanuelle M. Bayer
Lipids or Proteins: Who Is Leading the Dance at Membrane Contact Sites?
published pages: , ISSN: 1664-462X, DOI: 10.3389/fpls.2019.00198
|Frontiers in Plant Science 10||2020-02-06|
Dawei Yan, Shri Ram Yadav, Andrea Paterlini, William J. Nicolas, Jules D. Petit, Lysiane Brocard, Ilya Belevich, Magali S. Grison, Anne Vaten, Leila Karami, Sedeer el-Showk, Jung-Youn Lee, Gosia M. Murawska, Jenny Mortimer, Michael Knoblauch, Eija Jokitalo, Jonathan E. Markham, Emmanuelle M. Bayer, YkÃ¤ Helariutta
Sphingolipid biosynthesis modulates plasmodesmal ultrastructure and phloem unloading
published pages: 604-615, ISSN: 2055-0278, DOI: 10.1038/s41477-019-0429-5
|Nature Plants 5/6||2020-02-06|
Marie L Brault, Jules D Petit, FranÃ§oise Immel, William J Nicolas, Marie Glavier, Lysiane Brocard, AmÃ¨lia Gaston, Mathieu FouchÃ©, Timothy J Hawkins, Jeanâ€Marc Crowet, Magali S Grison, VÃ©ronique Germain, Marion Rocher, Max Kraner, Vikram Alva, StÃ©phane Claverol, Andrea Paterlini, YkÃ¤ Helariutta, Magali Deleu, Laurence Lins, Jens Tilsner, Emmanuelle M Bayer
Multiple C2 domains and transmembrane region proteins ( MCTP s) tether membranes at plasmodesmata
published pages: , ISSN: 1469-221X, DOI: 10.15252/embr.201847182
|EMBO reports 20/8||2020-02-06|
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