Opendata, web and dolomites


Contrast Agents for Protontherapy PET Range Monitoring

Total Cost €


EC-Contrib. €






 CAPPERAM project word cloud

Explore the words cloud of the CAPPERAM project. It provides you a very rough idea of what is the project "CAPPERAM" about.

concentration    dissintegration    experimental    solving    verification    radiation    deduce    detected    complutense    agents    mm    company    photons    section    scanners    strategy    lower    therapy    peaking    imaging    isotopes    phantom    causes    emission    radiactivity    relies    usual    emitters    sedecal    precision    contrast    first    spatial    computational    temporal    body    action    reactions    limited    dosimetric    tomography    follow    madrid    produces    electrons    capperam    technique    complicate    physics    zn    progress    comprising    secondment    medical    simulations    experiments    protons    fabrication    orders    commercial    magnitude    distributions    clinical    protontherapy    beams    irradiation    counts    accuracy    undergo    positron    nuclear    medicine    molecular    radioactive    activation    radiotherapy    near    cross    dose    specializes    relation    pet    patient    group    sections    energies    verify    delivered    place    university    relatively    advantage    conventional    vivo    interaction    depositions    proton   

Project "CAPPERAM" data sheet

The following table provides information about the project.


Organization address
city: MADRID
postcode: 28110
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SEDECAL MOLECULAR IMAGING SL ES (MADRID) coordinator 170˙121.00


 Project objective

In radiation therapy, proton therapy has a more favourable dose distribution than conventional radiotherapy with photons and electrons. However, in order to fully exploit this dosimetric advantage, it would be required to verify the range of protons in the patient with mm accuracy. The most used strategy for in-vivo range verification in protontherapy relies on positron emission tomography (PET) activation. As they progress through the patient, proton beams undergo nuclear reactions than can produce radioactive isotopes, some of which are positron-emitters. This induced radiactivity can be detected in commercial or dedicated PET scanners and used to deduce the delivered dose distribution in the patient.

While a promising technique, two main challenges have so far limited its clinical implementation: first, the proton interaction cross sections of the elements making up the body (C, O, N, H) are relatively low, which causes the positron dissintegration counts detected by the PET scanners to be about 1 or 2 orders of magnitude lower than the usual numbers in nuclear medicine. And second, the spatial and temporal distributions of PET emitters follow a very complex relation with the dose depositions which complicate the range verification process.

The CAPPERAM project aims at solving these two problems by using Zn-based contrast agents in the patient during irradiation. Zn has a very high cross section for proton interaction peaking at very low proton energies, which produces a very high concentration of PET emitters near the end of the proton range.

The action, comprising both computational simulations and phantom experiments, will take place in Sedecal Molecular Imaging, a company dedicated to the fabrication of high-precision PET devices, with a 6-month secondment at the group of Nuclear Physics of the Complutense University in Madrid, which specializes in applications of experimental nuclear physics to medical imaging.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CAPPERAM" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email ( and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CAPPERAM" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

iRhomADAM (2020)

Uncovering the role of the iRhom2-ADAM17 interaction in inflammatory signalling

Read More  

COLEX (2019)

Coopetition and Legislation in the Spanish Netherlands (1598-1665)

Read More  

NeuroSens (2019)

Neuromodulation of Sensory Processing

Read More