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Contrast Agents for Protontherapy PET Range Monitoring

Total Cost €


EC-Contrib. €






 CAPPERAM project word cloud

Explore the words cloud of the CAPPERAM project. It provides you a very rough idea of what is the project "CAPPERAM" about.

clinical    technique    capperam    counts    magnitude    spatial    action    molecular    dissintegration    follow    imaging    irradiation    scanners    verify    proton    simulations    patient    verification    energies    fabrication    produces    complicate    experiments    zn    medicine    delivered    radiotherapy    electrons    comprising    therapy    detected    depositions    sections    commercial    phantom    interaction    undergo    concentration    mm    dose    lower    causes    relation    protontherapy    orders    conventional    relies    radiation    temporal    pet    madrid    activation    positron    dosimetric    nuclear    cross    solving    vivo    place    complutense    advantage    progress    computational    beams    sedecal    usual    protons    reactions    relatively    secondment    medical    strategy    body    first    emitters    distributions    near    group    specializes    contrast    university    precision    company    isotopes    physics    radiactivity    photons    deduce    radioactive    tomography    section    emission    experimental    agents    accuracy    peaking    limited   

Project "CAPPERAM" data sheet

The following table provides information about the project.


Organization address
city: MADRID
postcode: 28110
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-SE
 Starting year 2018
 Duration (year-month-day) from 2018-12-01   to  2020-11-30


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    SEDECAL MOLECULAR IMAGING SL ES (MADRID) coordinator 170˙121.00


 Project objective

In radiation therapy, proton therapy has a more favourable dose distribution than conventional radiotherapy with photons and electrons. However, in order to fully exploit this dosimetric advantage, it would be required to verify the range of protons in the patient with mm accuracy. The most used strategy for in-vivo range verification in protontherapy relies on positron emission tomography (PET) activation. As they progress through the patient, proton beams undergo nuclear reactions than can produce radioactive isotopes, some of which are positron-emitters. This induced radiactivity can be detected in commercial or dedicated PET scanners and used to deduce the delivered dose distribution in the patient.

While a promising technique, two main challenges have so far limited its clinical implementation: first, the proton interaction cross sections of the elements making up the body (C, O, N, H) are relatively low, which causes the positron dissintegration counts detected by the PET scanners to be about 1 or 2 orders of magnitude lower than the usual numbers in nuclear medicine. And second, the spatial and temporal distributions of PET emitters follow a very complex relation with the dose depositions which complicate the range verification process.

The CAPPERAM project aims at solving these two problems by using Zn-based contrast agents in the patient during irradiation. Zn has a very high cross section for proton interaction peaking at very low proton energies, which produces a very high concentration of PET emitters near the end of the proton range.

The action, comprising both computational simulations and phantom experiments, will take place in Sedecal Molecular Imaging, a company dedicated to the fabrication of high-precision PET devices, with a 6-month secondment at the group of Nuclear Physics of the Complutense University in Madrid, which specializes in applications of experimental nuclear physics to medical imaging.

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The information about "CAPPERAM" are provided by the European Opendata Portal: CORDIS opendata.

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