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Clarifying role of the CENTROSOME in abnormal mitotic processes featuring the most commonchildhood malignancy: paediatric High Hyperdiploid Acute Lymphoblastic Leukaemia (HHDpALL)

Total Cost €


EC-Contrib. €






 CENTR-ALL project word cloud

Explore the words cloud of the CENTR-ALL project. It provides you a very rough idea of what is the project "CENTR-ALL" about.

al    acute    chromosomal    primary    variance    schwab    capacity    retain    diagnostic    centrosomes    scanning    electron    first    lymphoblastic    inter    sequential    leader    methodology    cancer    world    featured    evolvement    hhd    clustering    throughput    alwin    therapeutics    biology    illuminate    visualized    cell    functional    gain    amplification    cross    paediatric    align    fluorescence    gains    personal    evaluation    precise    malignancies    cin    mer    headed    leukaemia    centrosome    ca    mechanism    commercial    showed    inhibiting    dkfz    opposed    error    indicate    join    hematologic    tumour    instability    academic    et    technologies    clarified    hcclem    germany    er    avenue    researcher    embl    building    microscopy    immunocytochemistry    solid    accounts    original    time    mostly    institutes    light    hyperdiploidy    pall    aflm    auml    children    pathomechanism    deaths    laboratory    critical    professor    poorly    abnormalities    pattern    screening    ultrastructural    automated    therapeutic    hhdpall    genomics    desirable    metasystems    accordingly    prone    image    group    frequent    kr    viability    potentials    cells    issue    correlative   

Project "CENTR-ALL" data sheet

The following table provides information about the project.


Organization address
postcode: 69120

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-24   to  2021-01-23


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

Paediatric Acute Lymphoblastic Leukaemia (pALL) still accounts for most cancer-related deaths in children. Although high hyperdiploidy (HHD) is the most frequent pattern, its pathomechanism remains poorly understood. Recently, Experienced Researcher (ER) et al showed that sequential chromosomal gains and chromosomal instability (CIN) are critical features in HHD-pALL evolvement. The most common cause of CIN is centrosome amplification (CA) and recent findings indicate that inhibiting centrosome clustering (mechanism by which tumour cells control CA to retain viability) is a promising therapeutic avenue. Opposed to most solid and hematologic malignancies, the role of CA in HHDpALL has not been clarified thus far. Primary goal of ER is to illuminate this issue, which is expected to result in new diagnostic- and screening methodologies, as well as novel therapeutics. ER will join a leading group in the field of ‘cancer associated centrosome abnormalities’ (headed by Professor Alwin Krämer), in one of Europe’s largest cancer research institutes (DKFZ, Germany), applying state-of the art technologies in genomics and functional cell biology. Centrosomes are mostly visualized by immunocytochemistry, but precise evaluation is error prone and featured with inter-personal/-laboratory variance. A diagnostic and high-throughput screening methodology thus is highly desirable. Accordingly, second aim is to develop a novel automated fluorescence light microscopy (aFLM) application for centrosome analysis, building on ER's previous experience, but in a cross-sector collaboration with a non-academic world leader in image analysis (MetaSystems, Germany). To gain ultrastructural information as well, ER will also align aFLM with scanning electron microscopy for the first time, in collaboration with the Schwab Group (EMBL, Germany) creating high-capacity correlative light electron microscopy (hcCLEM). Commercial potentials of above original developments will also be investigated.

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