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CENTR-ALL SIGNED

Clarifying role of the CENTROSOME in abnormal mitotic processes featuring the most commonchildhood malignancy: paediatric High Hyperdiploid Acute Lymphoblastic Leukaemia (HHDpALL)

Total Cost €

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EC-Contrib. €

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Partnership

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 CENTR-ALL project word cloud

Explore the words cloud of the CENTR-ALL project. It provides you a very rough idea of what is the project "CENTR-ALL" about.

group    malignancies    schwab    prone    electron    hcclem    first    featured    therapeutic    aflm    capacity    mechanism    headed    light    professor    opposed    lymphoblastic    potentials    abnormalities    hematologic    amplification    leukaemia    sequential    solid    metasystems    children    automated    institutes    dkfz    biology    mer    functional    ultrastructural    image    original    personal    germany    instability    screening    et    alwin    methodology    retain    academic    critical    leader    pattern    therapeutics    centrosomes    visualized    world    variance    immunocytochemistry    cells    cancer    error    al    frequent    gains    showed    throughput    auml    pall    deaths    primary    technologies    hyperdiploidy    researcher    gain    evaluation    inter    precise    correlative    chromosomal    align    scanning    diagnostic    hhd    viability    issue    desirable    hhdpall    cell    paediatric    inhibiting    accordingly    centrosome    fluorescence    time    clustering    acute    commercial    cross    mostly    building    clarified    kr    pathomechanism    join    poorly    tumour    avenue    embl    microscopy    accounts    indicate    cin    er    illuminate    genomics    ca    evolvement    laboratory   

Project "CENTR-ALL" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-24   to  2021-01-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 171˙460.00

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 Project objective

Paediatric Acute Lymphoblastic Leukaemia (pALL) still accounts for most cancer-related deaths in children. Although high hyperdiploidy (HHD) is the most frequent pattern, its pathomechanism remains poorly understood. Recently, Experienced Researcher (ER) et al showed that sequential chromosomal gains and chromosomal instability (CIN) are critical features in HHD-pALL evolvement. The most common cause of CIN is centrosome amplification (CA) and recent findings indicate that inhibiting centrosome clustering (mechanism by which tumour cells control CA to retain viability) is a promising therapeutic avenue. Opposed to most solid and hematologic malignancies, the role of CA in HHDpALL has not been clarified thus far. Primary goal of ER is to illuminate this issue, which is expected to result in new diagnostic- and screening methodologies, as well as novel therapeutics. ER will join a leading group in the field of ‘cancer associated centrosome abnormalities’ (headed by Professor Alwin Krämer), in one of Europe’s largest cancer research institutes (DKFZ, Germany), applying state-of the art technologies in genomics and functional cell biology. Centrosomes are mostly visualized by immunocytochemistry, but precise evaluation is error prone and featured with inter-personal/-laboratory variance. A diagnostic and high-throughput screening methodology thus is highly desirable. Accordingly, second aim is to develop a novel automated fluorescence light microscopy (aFLM) application for centrosome analysis, building on ER's previous experience, but in a cross-sector collaboration with a non-academic world leader in image analysis (MetaSystems, Germany). To gain ultrastructural information as well, ER will also align aFLM with scanning electron microscopy for the first time, in collaboration with the Schwab Group (EMBL, Germany) creating high-capacity correlative light electron microscopy (hcCLEM). Commercial potentials of above original developments will also be investigated.

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