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CENTR-ALL SIGNED

Clarifying role of the CENTROSOME in abnormal mitotic processes featuring the most commonchildhood malignancy: paediatric High Hyperdiploid Acute Lymphoblastic Leukaemia (HHDpALL)

Total Cost €

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EC-Contrib. €

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Partnership

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 CENTR-ALL project word cloud

Explore the words cloud of the CENTR-ALL project. It provides you a very rough idea of what is the project "CENTR-ALL" about.

germany    prone    evolvement    featured    pattern    schwab    mechanism    viability    time    solid    opposed    functional    lymphoblastic    clarified    throughput    genomics    capacity    researcher    hhd    academic    critical    visualized    dkfz    align    gains    mostly    abnormalities    centrosomes    illuminate    chromosomal    hematologic    potentials    first    microscopy    accordingly    technologies    pall    institutes    acute    primary    error    cross    tumour    pathomechanism    electron    personal    alwin    commercial    aflm    et    hcclem    scanning    avenue    deaths    biology    diagnostic    world    metasystems    original    retain    group    evaluation    poorly    instability    hyperdiploidy    light    amplification    image    indicate    cell    fluorescence    automated    accounts    professor    screening    cancer    children    desirable    showed    centrosome    frequent    inhibiting    building    leader    ca    precise    mer    embl    auml    cin    er    ultrastructural    al    methodology    gain    paediatric    laboratory    correlative    clustering    variance    malignancies    issue    leukaemia    immunocytochemistry    cells    join    sequential    headed    therapeutic    inter    kr    hhdpall    therapeutics   

Project "CENTR-ALL" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG 

Organization address
address: IM NEUENHEIMER FELD 280
city: HEIDELBERG
postcode: 69120
website: www.dkfz.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 171˙460 €
 EC max contribution 171˙460 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2019
 Duration (year-month-day) from 2019-01-24   to  2021-01-23

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG DE (HEIDELBERG) coordinator 171˙460.00

Map

Leaflet | Map data © OpenStreetMap contributors, CC-BY-SA, Imagery © Mapbox

 Project objective

Paediatric Acute Lymphoblastic Leukaemia (pALL) still accounts for most cancer-related deaths in children. Although high hyperdiploidy (HHD) is the most frequent pattern, its pathomechanism remains poorly understood. Recently, Experienced Researcher (ER) et al showed that sequential chromosomal gains and chromosomal instability (CIN) are critical features in HHD-pALL evolvement. The most common cause of CIN is centrosome amplification (CA) and recent findings indicate that inhibiting centrosome clustering (mechanism by which tumour cells control CA to retain viability) is a promising therapeutic avenue. Opposed to most solid and hematologic malignancies, the role of CA in HHDpALL has not been clarified thus far. Primary goal of ER is to illuminate this issue, which is expected to result in new diagnostic- and screening methodologies, as well as novel therapeutics. ER will join a leading group in the field of ‘cancer associated centrosome abnormalities’ (headed by Professor Alwin Krämer), in one of Europe’s largest cancer research institutes (DKFZ, Germany), applying state-of the art technologies in genomics and functional cell biology. Centrosomes are mostly visualized by immunocytochemistry, but precise evaluation is error prone and featured with inter-personal/-laboratory variance. A diagnostic and high-throughput screening methodology thus is highly desirable. Accordingly, second aim is to develop a novel automated fluorescence light microscopy (aFLM) application for centrosome analysis, building on ER's previous experience, but in a cross-sector collaboration with a non-academic world leader in image analysis (MetaSystems, Germany). To gain ultrastructural information as well, ER will also align aFLM with scanning electron microscopy for the first time, in collaboration with the Schwab Group (EMBL, Germany) creating high-capacity correlative light electron microscopy (hcCLEM). Commercial potentials of above original developments will also be investigated.

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