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EnCAge TERMINATED

Progeria models to study endothelial cell ageing: implications for organ regeneration and fibrosis

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 EnCAge project word cloud

Explore the words cloud of the EnCAge project. It provides you a very rough idea of what is the project "EnCAge" about.

syndrome    liver    model    stem    physiological    cells    candidate    expression    compromise    hutchinson    health    drugs    injury    rare    reverse    prelamin    self    mice    disease    passive    fibrosis    regulate    vitro    guide    regeneration    tissues    time    repair    proven    instructive    causal    ec    elicit    nuclear    hgps    ageing    detected    prominent    dependent    form    fibrotic    gilford    mutant    induces    endothelial    consuming    dysfunction    modelled    societies    provoking    homeostasis    human    recapitulate    delivering    practical    individuals    levels    mechanisms    tissue    protein    experimental    alterations    organ    progeria    ecs    prevent    lost    blood    mouse    acquisition    angiocrine    conduits    expensive    disorders    progerin    tackle    aged    remarkably    phenotype    play    therapeutic    impairment    compounds    cell    throughput    convenient    screenings    age    caused    renewal    capillary    mimics    premature    specialized    functions    models   

Project "EnCAge" data sheet

The following table provides information about the project.

Coordinator
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) 

Organization address
address: CALLE MELCHOR FERNANDEZ ALMAGRO 3
city: MADRID
postcode: 28029
website: www.cnic.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 170˙121 €
 EC max contribution 170˙121 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2020
 Duration (year-month-day) from 2020-02-01   to  2022-01-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) ES (MADRID) coordinator 170˙121.00

Map

 Project objective

Capillary endothelial cells (ECs) are not just passive conduits for delivering blood. Rather, ECs also play tissue-specific functions by providing highly specialized sets of angiocrine factors that control tissue homeostasis, regulate stem cell self-renewal, and guide organ regeneration without provoking fibrosis. However, it is not known whether tissue-specific instructive functions of ECs are lost during ageing. Moreover, the causal role of EC ageing in age-associated tissue dysfunction has not been directly studied so far. The use of aged mice to study age-related tissue alterations and to develop new drugs is not practical, since it is expensive, time consuming and does not allow for high throughput screenings. Thus, it is key to develop more convenient experimental systems that recapitulate the phenotype of aged cells. Hutchinson-Gilford progeria syndrome (HGPS) is a rare disease caused by progerin, a mutant form of the nuclear protein prelamin A that induces premature ageing. Remarkably, HGPS mimics many of the characteristics of human ageing, and progerin has also been detected at low levels in aged tissues of non-HGPS individuals. Thus, HGPS experimental models have proven to be very useful for the study of physiological ageing. This proposal will study age-dependent and tissue-specific alterations in ECs using a mouse model of HGPS. Furthermore, the candidate will use mice with EC-specific expression of progerin to assess the causal role of EC ageing in age-related impairment of organ regeneration, modelled by liver repair after injury. Finally, the applicant will develop an in vitro system to identify mechanisms through which progerin-induced EC ageing may elicit fibrotic responses that could compromise organ repair, and to test compounds to prevent or reverse the acquisition of an aged EC phenotype. These studies will open new potential therapeutic approaches to tackle age-related disorders, one of the most prominent health issues in European societies.

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The information about "ENCAGE" are provided by the European Opendata Portal: CORDIS opendata.

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lastchecktime (2022-05-18 7:39:12) correctly updated