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LLPS-NMR SIGNED

Nuclear magnetic resonance spectroscopy of liquid-liquid phase separation

Total Cost €

0

EC-Contrib. €

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Partnership

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 LLPS-NMR project word cloud

Explore the words cloud of the LLPS-NMR project. It provides you a very rough idea of what is the project "LLPS-NMR" about.

biogenesis    microscopy    nanometer    kinetics    disordered    thermodynamics    posttranslational    innermost    rationale    liquid    fluids    nature    disentangle    massive    decipher    guidance    biggest    transform    density    droplets    forms    primarily    nucleic    regulate    proteins    underlies    reaction    light    formed    technologically    sub    stabilize    chemical    atomic    remained    intrinsically    polypeptide    successful    encapsulate    cellular    acids    spectroscopy    reactions    bioactive    description    critical    human    mechanobiology    energy    liquids    diseases    phenomenon    tackle    separated    break    resolution    structure    interactions    bottleneck    inherent    barrier    health    internal    nmr    transitions    chemistry    llps    forces    biochemical    composition    organization    separation    time    team    view    society    treatments    entropy    space    unmet    innovative    micrometer    designed    despite    mysterious    modifications    powerful    function    force    unravel    chambers    peptides    regulation    environment    push    protein    molecules   

Project "LLPS-NMR" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV 

Organization address
address: SIGMUND FREUD STRASSE 27
city: BONN
postcode: 53127
website: www.dzne.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙460˙278 €
 EC max contribution 2˙460˙278 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DE (BONN) coordinator 2˙460˙278.00

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 Project objective

Liquid-liquid phase separation (LLPS) is a phenomenon inherent to the thermodynamics of liquids, is critical for the development of technologically useful fluids and underlies some of the biggest health changes in our society. LLPS is based on transitions between two different forms of liquid that have the same chemical composition, but distinct energy, entropy and density. Despite the importance of LLPS for technology and health, however, only a very low-resolution view primarily through light microscopy is currently available for LLPS states formed by peptides and proteins. Because of this bottleneck, the interactions, which stabilize liquid droplets, and regulate their biogenesis, as well as a rationale for the biochemical function of LLPS, have remained mysterious.

To tackle this massive unmet need, I propose to develop powerful methods of NMR spectroscopy that go far beyond the state-of-the-art and team them up with mechanobiology/force microscopy to break the resolution barrier of polypeptide LLPS and push the description of the internal organization of liquid droplets from micrometer to sub-nanometer. Although highly challenging, the novel methods when successful will (i) disentangle the structure and kinetics of intrinsically disordered proteins within LLPS reaction chambers in space and time, (ii) unravel the nature of chemical reactions in liquid droplets, and (iii) decipher LLPS regulation by posttranslational modifications, nucleic acids and critical changes in cellular environment at atomic resolution. The innovative nature of the proposal is designed to unravel the innermost forces in liquid droplets and to transform our knowledge about the chemistry of liquid phase-separated protein states. Findings from this proposal will provide critical guidance in the development of systems to encapsulate bioactive molecules and to develop better treatments for human diseases.

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