Opendata, web and dolomites

LLPS-NMR SIGNED

Nuclear magnetic resonance spectroscopy of liquid-liquid phase separation

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 LLPS-NMR project word cloud

Explore the words cloud of the LLPS-NMR project. It provides you a very rough idea of what is the project "LLPS-NMR" about.

polypeptide    time    modifications    transform    cellular    human    organization    chemistry    description    interactions    regulate    treatments    primarily    mechanobiology    nanometer    nature    liquids    stabilize    molecules    thermodynamics    barrier    separation    successful    decipher    resolution    liquid    designed    composition    health    encapsulate    forces    diseases    despite    innovative    sub    atomic    fluids    separated    remained    kinetics    disentangle    chemical    light    unravel    bottleneck    innermost    underlies    acids    rationale    critical    droplets    inherent    biochemical    biggest    push    mysterious    force    technologically    team    break    massive    phenomenon    disordered    intrinsically    view    density    posttranslational    protein    energy    peptides    bioactive    structure    reactions    nucleic    llps    spectroscopy    powerful    microscopy    proteins    micrometer    function    entropy    biogenesis    formed    chambers    internal    space    nmr    transitions    reaction    regulation    tackle    unmet    forms    environment    society    guidance   

Project "LLPS-NMR" data sheet

The following table provides information about the project.

Coordinator
DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV 

Organization address
address: SIGMUND FREUD STRASSE 27
city: BONN
postcode: 53127
website: www.dzne.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Total cost 2˙460˙278 €
 EC max contribution 2˙460˙278 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2023-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    DEUTSCHES ZENTRUM FUR NEURODEGENERATIVE ERKRANKUNGEN EV DE (BONN) coordinator 2˙460˙278.00

Map

 Project objective

Liquid-liquid phase separation (LLPS) is a phenomenon inherent to the thermodynamics of liquids, is critical for the development of technologically useful fluids and underlies some of the biggest health changes in our society. LLPS is based on transitions between two different forms of liquid that have the same chemical composition, but distinct energy, entropy and density. Despite the importance of LLPS for technology and health, however, only a very low-resolution view primarily through light microscopy is currently available for LLPS states formed by peptides and proteins. Because of this bottleneck, the interactions, which stabilize liquid droplets, and regulate their biogenesis, as well as a rationale for the biochemical function of LLPS, have remained mysterious.

To tackle this massive unmet need, I propose to develop powerful methods of NMR spectroscopy that go far beyond the state-of-the-art and team them up with mechanobiology/force microscopy to break the resolution barrier of polypeptide LLPS and push the description of the internal organization of liquid droplets from micrometer to sub-nanometer. Although highly challenging, the novel methods when successful will (i) disentangle the structure and kinetics of intrinsically disordered proteins within LLPS reaction chambers in space and time, (ii) unravel the nature of chemical reactions in liquid droplets, and (iii) decipher LLPS regulation by posttranslational modifications, nucleic acids and critical changes in cellular environment at atomic resolution. The innovative nature of the proposal is designed to unravel the innermost forces in liquid droplets and to transform our knowledge about the chemistry of liquid phase-separated protein states. Findings from this proposal will provide critical guidance in the development of systems to encapsulate bioactive molecules and to develop better treatments for human diseases.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "LLPS-NMR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "LLPS-NMR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

LO-KMOF (2019)

Vapour-deposited metal-organic frameworks as high-performance gap-filling dielectrics for nanoelectronics

Read More  

PLAT_ACE (2019)

A new platform technology for the on-demand access to large acenes

Read More  

TRUST (2018)

Truth and Semantics

Read More