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BacDrug SIGNED

Bacterial membrane vesicles a novel delivery system for the treatment of multi-drug resistant Gram-negative bacterial infections.

Total Cost €

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EC-Contrib. €

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Partnership

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 BacDrug project word cloud

Explore the words cloud of the BacDrug project. It provides you a very rough idea of what is the project "BacDrug" about.

drugs    treatments    clinics    mortality    bioengineering    outcome    prof    tackle    environment    successful    dr    edwards    burden    pass    placed    nanocarriers    consequently    provides    diseases    vesicles    alternative    pathogens    engineering    fellowship    negative    outer    techniques    lactis    drug    delivering    lactococcus    urgent    bacteria    dearth    pathogenic    spread    stevens    health    molly    antibiotics    highest    bacterial    strategy    chemical    strategies    alarming    resistance    global    collaborative    innovative    nanotechnology    selective    cross    themselves    interdisciplinary    cargo    gram    molecular    maximise    training    therapeutic    human    world    combat    truly    genetic    materials    translational    icl    treatment    setting    lipid    class    globally    combined    organization    payload    clinical    public    bacdrug    indispensable    harness    groups    toxic    biology    protect    microbiology    frequent    bmvs    prevention    resistant    coupled    combines    infections    exploited    expertise    led    load    kill    shortage    andrew    faculty    membrane    caused    acute   

Project "BacDrug" data sheet

The following table provides information about the project.

Coordinator		 IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE 

Organization address
address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD
city: LONDON
postcode: SW7 2AZ
website: http://www.imperial.ac.uk/

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
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 Coordinator Country United Kingdom [UK]
 Total cost 212˙933 €
 EC max contribution 212˙933 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2018
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE UK (LONDON) coordinator 212˙933.00

Map

 Project objective

'Bacterial infections are a significant public health challenge and a major cause of human mortality globally. Antibiotics are indispensable for the treatment and prevention of infections caused by bacteria. However, global spread of drug-resistant bacteria, coupled with a dearth of new antibiotics in development has led to an alarming shortage of effective drugs. Gram-negative bacteria, in particular, protect themselves against antibiotics with a highly selective outer membrane. The high burden of diseases caused by Gram-negative bacteria, combined with their frequent multi-drug resistance has placed them as world´s highest-priority pathogens by the World Health Organization. Consequently, there is an urgent need for novel therapeutic approaches that combat Gram-negative bacterial pathogens. The goal of 'BacDrug' is to use lipid-based bacterial membrane vesicles (BMVs) produced by non-pathogenic Lactococcus lactis as delivery system. BMVs have great potential as nanocarriers to by-pass the outer membrane and deliver their toxic payload to kill drug-resistant Gram-negative pathogens. A range of strategies will be used to load BMVs with cargo, including genetic engineering of L. lactis as well as chemical treatments. This Fellowship will harness expertise and techniques across microbiology, molecular biology, nanotechnology and drug design to deliver a successful outcome. The collaborative, truly interdisciplinary, cross faculty setting within the groups of Prof Molly Stevens (materials and bioengineering) and Dr Andrew Edwards (molecular microbiology) at ICL combines world-class expertise and provides an environment to maximise the success of this Fellowship, both in terms of the delivering the project and the training opportunities provided. Moreover, this innovative, alternative strategy to tackle drug-resistant Gram-negative bacterial infections has a high translational potential, which will be exploited via the clinical and translational research clinics at ICL.'

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The information about "BACDRUG" are provided by the European Opendata Portal: CORDIS opendata.

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