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SCCMMI SIGNED

Single cell correlates of memory, motivation and individuality

Total Cost €

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EC-Contrib. €

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Partnership

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 SCCMMI project word cloud

Explore the words cloud of the SCCMMI project. It provides you a very rough idea of what is the project "SCCMMI" about.

context    gene    entire    labeled    unprecedented    reward    conserved    permits    stimuli    material    edge    seq    drosophila    heterogeneous    dopaminergic    fluorescently    small    signals    transcriptomes    internal    persistent    first    neurons    drugs    conservation    purified    celllevel    individual    innervate    motivated    fruit    experiments    cutting    simultaneous    pooled    dissected    sensory    thousands    view    genetically    rnas    direction    capturing    bodies    alter    bead    directed    maintenance    mechanisms    drop    molecules    operates    medicine    obscured    perspective    nanolitre    relatively    encoded    prior    re    regions    individually    until    behave    temporally    evaluation    collection    sites    form    memory    mushroom    collections    therapeutic    obscure    cells    learning    reaction    implanted    oligonucleotide    integration    averaging    brain    molecular    fly    seek    located    tools    gain    revealed    droplet    altered    knowing    cell    types    behavior    cellular    neural    coated    populations    region    memories    evident    emerges    volume    recognised    transcriptional    action    expression    broad    function    messenger    rewards    flies   

Project "SCCMMI" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙055 €
 EC max contribution 2˙499˙055 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙499˙055.00

Map

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 Project objective

Directed behavior emerges from neural integration of sensory stimuli, memory of prior experience and internal states. We seek an understanding of these conserved neural mechanisms using genetically-encoded tools and the relatively small brain of the fruit fly Drosophila. By temporally controlling neural function memories can be implanted and internal states altered so that most flies behave according to our direction. Our recent studies have revealed a role for distinct subsets of dopaminergic neurons that innervate a brain region called the mushroom bodies in reward learning, memory re-evaluation and the control of motivated behavior. Although it is recognised that new gene expression is required to form persistent memories, and molecules are the targets of all therapeutic drugs in medicine, the relevant cellular sites of action often remain obscure. Knowing where memories are located in the fly brain therefore makes it possible to gain molecular level insight, with a unique perspective of being embedded within a relevant cell-specific context, of how a brain operates to alter behavior in response to rewards and internal state. Until recently, most studies of gene expression in the brain have pooled messenger RNAs purified from the entire brain, dissected regions, or small populations of fluorescently labeled material. Cell-specific expression and responses are therefore obscured by averaging signals from, often heterogeneous, collections of cells and cell-types. We will use cutting-edge Drop-seq, which permits simultaneous collection of transcriptomes from thousands of individually identified cells by first capturing each cell with a unique oligonucleotide-coated bead in a nanolitre volume reaction droplet. Our experiments will therefore provide an unprecedented individual celllevel view of transcriptional responses to memory formation and maintenance and are likely to be of broad importance and interest, given the evident conservation of gene function.

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The information about "SCCMMI" are provided by the European Opendata Portal: CORDIS opendata.

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