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SCCMMI SIGNED

Single cell correlates of memory, motivation and individuality

Total Cost €

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EC-Contrib. €

0

Partnership

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 SCCMMI project word cloud

Explore the words cloud of the SCCMMI project. It provides you a very rough idea of what is the project "SCCMMI" about.

therapeutic    transcriptional    heterogeneous    tools    bead    averaging    view    operates    oligonucleotide    altered    drugs    direction    transcriptomes    broad    persistent    small    volume    dissected    function    implanted    simultaneous    messenger    relatively    fruit    knowing    re    neural    cellular    temporally    drosophila    motivated    permits    stimuli    regions    recognised    seek    dopaminergic    mushroom    fly    labeled    populations    conservation    first    rnas    perspective    molecular    rewards    context    emerges    material    obscure    genetically    bodies    cell    unprecedented    conserved    form    droplet    obscured    neurons    individually    individual    gene    signals    brain    evident    maintenance    behavior    revealed    experiments    types    cells    pooled    molecules    drop    gain    thousands    sensory    behave    located    entire    expression    collections    capturing    seq    collection    prior    reaction    encoded    reward    memory    action    cutting    learning    evaluation    memories    alter    until    purified    internal    flies    medicine    celllevel    sites    fluorescently    edge    innervate    region    directed    coated    nanolitre    integration    mechanisms   

Project "SCCMMI" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙055 €
 EC max contribution 2˙499˙055 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙499˙055.00

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 Project objective

Directed behavior emerges from neural integration of sensory stimuli, memory of prior experience and internal states. We seek an understanding of these conserved neural mechanisms using genetically-encoded tools and the relatively small brain of the fruit fly Drosophila. By temporally controlling neural function memories can be implanted and internal states altered so that most flies behave according to our direction. Our recent studies have revealed a role for distinct subsets of dopaminergic neurons that innervate a brain region called the mushroom bodies in reward learning, memory re-evaluation and the control of motivated behavior. Although it is recognised that new gene expression is required to form persistent memories, and molecules are the targets of all therapeutic drugs in medicine, the relevant cellular sites of action often remain obscure. Knowing where memories are located in the fly brain therefore makes it possible to gain molecular level insight, with a unique perspective of being embedded within a relevant cell-specific context, of how a brain operates to alter behavior in response to rewards and internal state. Until recently, most studies of gene expression in the brain have pooled messenger RNAs purified from the entire brain, dissected regions, or small populations of fluorescently labeled material. Cell-specific expression and responses are therefore obscured by averaging signals from, often heterogeneous, collections of cells and cell-types. We will use cutting-edge Drop-seq, which permits simultaneous collection of transcriptomes from thousands of individually identified cells by first capturing each cell with a unique oligonucleotide-coated bead in a nanolitre volume reaction droplet. Our experiments will therefore provide an unprecedented individual celllevel view of transcriptional responses to memory formation and maintenance and are likely to be of broad importance and interest, given the evident conservation of gene function.

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The information about "SCCMMI" are provided by the European Opendata Portal: CORDIS opendata.

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