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SCCMMI SIGNED

Single cell correlates of memory, motivation and individuality

Total Cost €

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EC-Contrib. €

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Partnership

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 SCCMMI project word cloud

Explore the words cloud of the SCCMMI project. It provides you a very rough idea of what is the project "SCCMMI" about.

form    entire    maintenance    averaging    droplet    molecular    medicine    capturing    mushroom    neurons    gain    gene    molecules    individually    labeled    bodies    bead    brain    coated    nanolitre    encoded    integration    emerges    re    types    temporally    small    collections    signals    context    populations    flies    revealed    cell    celllevel    rewards    tools    simultaneous    motivated    relatively    dissected    drosophila    transcriptomes    altered    sensory    rnas    messenger    transcriptional    region    oligonucleotide    fruit    persistent    memories    volume    fly    reward    cells    memory    direction    prior    fluorescently    conserved    material    therapeutic    pooled    evident    conservation    purified    genetically    unprecedented    expression    cutting    drugs    operates    seek    mechanisms    obscured    action    view    stimuli    collection    individual    cellular    until    reaction    neural    learning    experiments    alter    directed    thousands    perspective    located    knowing    permits    behavior    drop    heterogeneous    sites    seq    evaluation    broad    obscure    implanted    function    recognised    edge    regions    innervate    dopaminergic    internal    first    behave   

Project "SCCMMI" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD 

Organization address
address: WELLINGTON SQUARE UNIVERSITY OFFICES
city: OXFORD
postcode: OX1 2JD
website: www.ox.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 2˙499˙055 €
 EC max contribution 2˙499˙055 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2017-ADG
 Funding Scheme ERC-ADG
 Starting year 2018
 Duration (year-month-day) from 2018-10-01   to  2023-09-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD UK (OXFORD) coordinator 2˙499˙055.00

Map

 Project objective

Directed behavior emerges from neural integration of sensory stimuli, memory of prior experience and internal states. We seek an understanding of these conserved neural mechanisms using genetically-encoded tools and the relatively small brain of the fruit fly Drosophila. By temporally controlling neural function memories can be implanted and internal states altered so that most flies behave according to our direction. Our recent studies have revealed a role for distinct subsets of dopaminergic neurons that innervate a brain region called the mushroom bodies in reward learning, memory re-evaluation and the control of motivated behavior. Although it is recognised that new gene expression is required to form persistent memories, and molecules are the targets of all therapeutic drugs in medicine, the relevant cellular sites of action often remain obscure. Knowing where memories are located in the fly brain therefore makes it possible to gain molecular level insight, with a unique perspective of being embedded within a relevant cell-specific context, of how a brain operates to alter behavior in response to rewards and internal state. Until recently, most studies of gene expression in the brain have pooled messenger RNAs purified from the entire brain, dissected regions, or small populations of fluorescently labeled material. Cell-specific expression and responses are therefore obscured by averaging signals from, often heterogeneous, collections of cells and cell-types. We will use cutting-edge Drop-seq, which permits simultaneous collection of transcriptomes from thousands of individually identified cells by first capturing each cell with a unique oligonucleotide-coated bead in a nanolitre volume reaction droplet. Our experiments will therefore provide an unprecedented individual celllevel view of transcriptional responses to memory formation and maintenance and are likely to be of broad importance and interest, given the evident conservation of gene function.

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The information about "SCCMMI" are provided by the European Opendata Portal: CORDIS opendata.

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