Opendata, web and dolomites

MuSeq SIGNED

Defining the Oligodendrocyte Lineage in Multiple Sclerosis Lesions by Single Cell RNA-Sequencing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 MuSeq project word cloud

Explore the words cloud of the MuSeq project. It provides you a very rough idea of what is the project "MuSeq" about.

internationally    university    bank    multidisciplinary    antibody    experts    individual    sequencing    regenerative    fail    turn    single    time    neuroscience    degree    post    stages    drive    translational    track    remyelination    classification    guidance    mechanisms    ms    therapies    insufficiently    researcher    oligodendrocyte    independent    repair    sclerosis    mortem    heterogeneity    rna    tissue    public    healthy    unravel    answering    whom    patients    powerful    lesions    human    scrna    multiple    leads    me    revealing    snrna    record    expertise    neurodegeneration    motivation    stockholm    stage    excellence    pave    failed    laboratory    innovative    overcoming    world    karolinska    first    seq    edinburgh    labelling    rational    foundations    equip    generate    skills    sensitive    functional    extra    secondment    brain    nuclear    career    sensitivity    neuropathological    progressive    roadblocks    technologies    at    therapeutics    overcome    medical    differentiation    detect    database    cell    patterns    web    museq    scientific    ol    lay   

Project "MuSeq" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 195˙454.00

Map

 Project objective

At which stage in oligodendrocyte (OL) differentiation does remyelination in Multiple Sclerosis (MS) lesions fail? Answering this is essential for developing new therapies for progressive MS patients in whom failed remyelination leads to neurodegeneration. Current neuropathological technologies using antibody labelling are insufficiently sensitive to detect each of the possible stages at which the process might fail. In MuSeq, I will therefore use single cell and single nuclear RNA-sequencing (scRNA-seq and snRNA-seq) technologies to define the stages of OL differentiation in human post-mortem brain in healthy and in MS tissue available to me from the Edinburgh tissue bank. By overcoming the problems of sensitivity and revealing the degree of heterogeneity within lesions, this innovative and multidisciplinary project will for the first time unravel the patterns of OL differentiation and its failure in human MS lesions. This in turn will generate a new and powerful classification system for MS lesions based on their regenerative potential, and generate an open-access web database for future functional studies beyond this project and laboratory. By identifying those key roadblocks that need to be overcome to promote remyelination, MuSeq will lay the foundations for rational therapeutics to improve the repair mechanisms of individual MS patients and thus promote European scientific excellence. The project will be carried out under the guidance of leading experts at the University of Edinburgh with a secondment at the Karolinska Institute (Stockholm), a world-leading medical research institution. Results from the project will be used to raise public awareness on the importance of innovative MS research. I have the track-record, expertise and motivation to drive this IF project, and this will equip me with the extra skills I need to pave the way for my future career as an independent researcher in the field of translational neuroscience in Europe and internationally.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "MUSEQ" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "MUSEQ" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

NaWaTL (2020)

Narrative, Writing, and the Teotihuacan Language: Exploring Language History Through Phylogenetics, Epigraphy and Iconography

Read More  

PNAIC (2018)

Positive and Negative Asymmetry in Intergroup Contact: Its Impact on Linguistic Forms of Communication and Physiological Responses

Read More  

MathematicsAnalogies (2019)

Mathematics Analogies

Read More