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MuSeq SIGNED

Defining the Oligodendrocyte Lineage in Multiple Sclerosis Lesions by Single Cell RNA-Sequencing

Total Cost €

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EC-Contrib. €

0

Partnership

0

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 MuSeq project word cloud

Explore the words cloud of the MuSeq project. It provides you a very rough idea of what is the project "MuSeq" about.

therapeutics    expertise    secondment    cell    labelling    rational    first    seq    edinburgh    translational    sensitivity    unravel    snrna    university    classification    insufficiently    extra    stage    stockholm    patients    karolinska    skills    brain    revealing    neurodegeneration    lesions    public    rna    oligodendrocyte    mechanisms    laboratory    motivation    roadblocks    post    progressive    patterns    multidisciplinary    functional    neuropathological    time    scrna    record    degree    sclerosis    mortem    whom    foundations    bank    overcoming    powerful    excellence    me    track    repair    multiple    web    answering    scientific    generate    researcher    drive    detect    experts    turn    at    guidance    world    ms    tissue    ol    equip    antibody    individual    stages    nuclear    single    healthy    fail    remyelination    heterogeneity    independent    sensitive    lay    technologies    human    museq    failed    pave    database    sequencing    career    overcome    medical    therapies    leads    internationally    innovative    neuroscience    differentiation    regenerative   

Project "MuSeq" data sheet

The following table provides information about the project.

Coordinator
THE UNIVERSITY OF EDINBURGH 

Organization address
address: OLD COLLEGE, SOUTH BRIDGE
city: EDINBURGH
postcode: EH8 9YL
website: www.ed.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-05-01   to  2020-09-02

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE UNIVERSITY OF EDINBURGH UK (EDINBURGH) coordinator 195˙454.00

Map

 Project objective

At which stage in oligodendrocyte (OL) differentiation does remyelination in Multiple Sclerosis (MS) lesions fail? Answering this is essential for developing new therapies for progressive MS patients in whom failed remyelination leads to neurodegeneration. Current neuropathological technologies using antibody labelling are insufficiently sensitive to detect each of the possible stages at which the process might fail. In MuSeq, I will therefore use single cell and single nuclear RNA-sequencing (scRNA-seq and snRNA-seq) technologies to define the stages of OL differentiation in human post-mortem brain in healthy and in MS tissue available to me from the Edinburgh tissue bank. By overcoming the problems of sensitivity and revealing the degree of heterogeneity within lesions, this innovative and multidisciplinary project will for the first time unravel the patterns of OL differentiation and its failure in human MS lesions. This in turn will generate a new and powerful classification system for MS lesions based on their regenerative potential, and generate an open-access web database for future functional studies beyond this project and laboratory. By identifying those key roadblocks that need to be overcome to promote remyelination, MuSeq will lay the foundations for rational therapeutics to improve the repair mechanisms of individual MS patients and thus promote European scientific excellence. The project will be carried out under the guidance of leading experts at the University of Edinburgh with a secondment at the Karolinska Institute (Stockholm), a world-leading medical research institution. Results from the project will be used to raise public awareness on the importance of innovative MS research. I have the track-record, expertise and motivation to drive this IF project, and this will equip me with the extra skills I need to pave the way for my future career as an independent researcher in the field of translational neuroscience in Europe and internationally.

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The information about "MUSEQ" are provided by the European Opendata Portal: CORDIS opendata.

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