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TREGinAD SIGNED

Role of Aβ Specific Regulatory T cells in harnessing cerebral Aβ clearance in Alzheimer’s Disease

Total Cost €

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EC-Contrib. €

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Partnership

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 TREGinAD project word cloud

Explore the words cloud of the TREGinAD project. It provides you a very rough idea of what is the project "TREGinAD" about.

populations    brain    alteration    therapeutic    regulatory    interdisciplinary    inter    pathogenic    phagocytic    trinity    ageing    health    critical    immunology    disease    college    partly    mouse    model    reinforce    paracrine    improper    population    mechanisms    safer    neglect    public    with    lynch    strengthen    ps1    neuroscientists    skills    periphery    dublin    enter    input    prof    cure    pave    inflammation    cerebral    sentinels    vaccines    adaptive    immune    cells    physically    reducing    myself    inflammatory    sectoral    pathoethiology    teaching    microglia    trials    supervised    severe    erc    draw    clear    microglial    amplify    innate    effect    cns    neuroscience    clearance    neuroinflammation    cell    ad    instruction    beta    contribution    resident    regulate    accompanied    effector    strategy    unknown    keeping    occurs    clinical    leaders    multidisciplinary    immunologists    clearer    alzheimer    hosted    mediated    agent    treg    tools    app    alter    completion    action   

Project "TREGinAD" data sheet

The following table provides information about the project.

Coordinator
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN 

Organization address
address: College Green
city: DUBLIN
postcode: 2
website: www.tcd.ie

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Ireland [IE]
 Total cost 187˙866 €
 EC max contribution 187˙866 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-RI
 Starting year 2018
 Duration (year-month-day) from 2018-04-01   to  2020-09-27

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN IE (DUBLIN) coordinator 187˙866.00

Map

 Project objective

With populations ageing, Alzheimer’s disease (AD), for which there is still no cure, has become a major public health problem in Europe. This is partly due to the neglect of the role of the immune responses to the build-up of cerebral Aβ-the pathogenic agent triggering AD. Clinical trials for vaccines aimed at reducing cerebral Aβ were accompanied by severe side effects due to improper neuroinflammation. While the input of microglia, the brain resident innate immune sentinels, is becoming clearer, the impact of the adaptive immune system, specifically T cells is still unknown. A promising therapeutic strategy, would be to strengthen Aβ-induced regulatory T cells (Treg), to alter the effector T cell mediated inflammatory response, while promoting clearance of Aβ by microglia. My interdisciplinary project hosted by Trinity College Dublin and supervised by Prof Lynch will draw together both Neuroscience and Immunology. I propose to assess the effect of Aβ-specific Treg on the pathoethiology of AD. To this aim, I will amplify a population of Aβ-specific Treg in the APP/PS1 mouse model of AD and will 1) assess if Aβ-specific Treg can regulate instruction of microglia to clear cerebral Aβ, while keeping inflammation under control, 2) determine if this regulatory effect occurs via paracrine mechanisms from the periphery or if Treg physically enter the CNS and 3) identify other Aβ-specific T cell populations involved in response to cerebral Aβ build-up and in alteration of microglial phagocytic activity. Completion of this project will make a critical contribution to the understanding of the immune response in AD and will pave the way towards safer therapeutic tools. The proposed action will allow the dissemination of my work to both neuroscientists, immunologists, and the general public. I will reinforce my multidisciplinary and inter-sectoral skills, improve my management and teaching experience to establish myself among the leaders of research at ERC level.

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The information about "TREGINAD" are provided by the European Opendata Portal: CORDIS opendata.

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