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Modulating brain structural plasticity versus neurodegeneration via a novel mechanism involving neurotrophins and dopamine, Tolls and Kek truncated-Trk-like receptors in Drosophila.

Total Cost €


EC-Contrib. €






 TOLKEDA project word cloud

Explore the words cloud of the TOLKEDA project. It provides you a very rough idea of what is the project "TOLKEDA" about.

vs    drosophila    maintains    discover    er    neuromodulator    adapt    linking    incidence    registration    structural    cancer    put    module    manipulating    plasticity    degeneration    neurological    dans    drives    disease    synapses    neurotrophins    hidalgo    expert    alicia    preliminary    discovered    gene    neuroprotection    signalling    generation    researcher    jun    neurodegeneration    ro2    neural    linked    neurodegenerative    dopamine    deficits    map    elimination    cardiovascular    ros    diseases    neurites    circuit    burden    tolls    trk    operates    models    brain    homeostasis    sun    parkinson    health    molecular    synaptic    neuronal    formed    editing    imperative    treat    hypothesis    life    neurons    neurotrophin    causes    ages    pd    synergy    create    dnts    altering    demonstrated    functions    principal    overlapping    tolkeda    ro3    costing    model    investigator    mechanism    kek    dnt    behavioural    underlies    ro1    truncated    pi    receptors    dr    grow    shows    ageing    population    toll    modulates    provoke    adult    larvae    dopaminergic   

Project "TOLKEDA" data sheet

The following table provides information about the project.


Organization address
address: Edgbaston
postcode: B15 2TT

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2017
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-08-01   to  2020-07-31


Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 


 Project objective

The aim of TOLKEDA is to test the hypothesis that a novel molecular mechanism linking neurotrophins, Tolls and truncated Trk-like receptors modulates structural brain plasticity vs. neurodegeneration. The brain changes throughout life: structural plasticity drives generation of neurites, neurons and synapses to adapt and learn; their elimination maintains homeostasis, but causes neurodegeneration in ageing and disease. Brain disease is the major health burden in Europe, costing more than cancer and cardiovascular diseases put together, and its incidence will grow as the population ages. It is imperative to discover novel molecular pathways that can be targeted to treat brain disease. The Principal Investigator (PI) Dr Alicia Hidalgo recently discovered a novel Drosophila neurotrophin (DNT) mechanism formed of neurotrophins, Toll and truncated-Trk-like receptors, and demonstrated that it underlies neuronal number and synaptic structural plasticity in larvae. Preliminary evidence shows that the DNT system operates in the adult brain, overlapping with dopaminergic neurons (DANs). Dopamine is a key neuromodulator, and degeneration of DANs underlies neurological and neurodegenerative diseases, such as Parkinson’s disease (PD). The Experienced Researcher (ER), Jun Sun, is an expert in the dopaminergic system and Drosophila PD models. The timely collaboration between PI and ER will provoke synergy to address effectively the following research objectives (ROs): RO1: to create a map of DNTs, Toll-6, Kek-6 and DANs in the adult brain, using gene editing technology and neural circuit registration. RO2: to test whether altering the functions of DNTs, Toll-6 and Kek-6 causes structural brain deficits, including in the dopaminergic system, and whether they are linked to behavioural deficits and neuronal activity. RO3: to test whether manipulating the DNT/Toll-6/Kek-6 signalling module in the dopaminergic system can promote neuroprotection in a Drosophila PD model.

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The information about "TOLKEDA" are provided by the European Opendata Portal: CORDIS opendata.

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